Zobrazeno 1 - 10
of 450
pro vyhledávání: '"Naoto Oku"'
Autor:
Hiroyuki Koide, Anna Okishima, Yu Hoshino, Yuri Kamon, Keiichi Yoshimatsu, Kazuhiro Saito, Ikumi Yamauchi, Saki Ariizumi, Yuqi Zhou, Ting-Hui Xiao, Keisuke Goda, Naoto Oku, Tomohiro Asai, Kenneth J. Shea
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Sepsis caused by the release of inflammatory mediators into the blood is a life threatening disease. Here, the authors report on the development of hydrogel nanoparticles for the capture and neutralisation of histones, major inflammatory mediators, a
Externí odkaz:
https://doaj.org/article/eb612ef6ea67468793984170be09b6f2
Autor:
Minoru Numata, Akane Hirano, Yukika Yamamoto, Michiko Yasuda, Nobuhiko Miura, Kazutoshi Sayama, Masa-Aki Shibata, Tomohiro Asai, Naoto Oku, Noriyuki Miyoshi, Kayoko Shimoi
Publikováno v:
Journal of Circadian Rhythms, Vol 19, Iss 1 (2021)
Epidemiological studies have indicated that a disturbed circadian rhythm resulting from night-shift work is a potential risk factor for breast cancer. However, the mechanism of increased risk of breast cancer by night-shift work remains unclear, and
Externí odkaz:
https://doaj.org/article/04e209f79b64459b8c60ccc245e848e8
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 361 (2022)
Ischemic stroke is still one of the leading causes of high mortality and severe disability worldwide. Therapeutic options for ischemic stroke and subsequent cerebral ischemia/reperfusion injury remain limited due to challenges associated with drug pe
Externí odkaz:
https://doaj.org/article/b3c27f17c4064d0eb3160f8399ae9b2b
Autor:
Liqing Zang, Yasuhito Shimada, Hiroko Nakayama, Wenbiao Chen, Ayaka Okamoto, Hiroyuki Koide, Naoto Oku, Takehisa Dewa, Masayuki Shiota, Norihiro Nishimura
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Type 2 diabetes mellitus (T2DM) is characterized by persistent hyperglycemia and is influenced by genetic and environmental factors. Optimum T2DM management involves early diagnosis and effective glucose-lowering therapies. Further research is warran
Externí odkaz:
https://doaj.org/article/a6d9febec8aa4a38b51628dd248b7115
Autor:
Keiji Okuda, Hai Ying Fu, Takashi Matsuzaki, Ryo Araki, Shota Tsuchida, Punniyakoti V Thanikachalam, Tatsuya Fukuta, Tomohiro Asai, Masaki Yamato, Shoji Sanada, Hiroshi Asanuma, Yoshihiro Asano, Masanori Asakura, Haruo Hanawa, Hiroyuki Hao, Naoto Oku, Seiji Takashima, Masafumi Kitakaze, Yasushi Sakata, Tetsuo Minamino
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160944 (2016)
Immunosuppressive agents are used for the treatment of immune-mediated myocarditis; however, the need to develop a more effective therapeutic approach remains. Nano-sized liposomes may accumulate in and selectively deliver drugs to an inflammatory le
Externí odkaz:
https://doaj.org/article/b6f03b9b98d0466baa5ef429389f3cb6
Autor:
Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, Naoto Oku
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e85520 (2014)
The aim of this study was to achieve real-time imaging of the in vivo behavior of a green tea polyphenol, catechin, by positron emission tomography (PET). Positron-labeled 4″ -[(11)C]methyl-epigallocatechin gallate ([(11)C]Me-EGCG) was orally admin
Externí odkaz:
https://doaj.org/article/2cfb9acdab194b78a86cfdbd3db268b4
Autor:
Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e81941 (2014)
Sialidase removes sialic acid from sialoglycoconjugates and plays crucial roles in many physiological and pathological processes. Various human cancers express an abnormally high level of the plasma membrane-associated sialidase isoform.Visualization
Externí odkaz:
https://doaj.org/article/d1b1bdab500f4635a9f3d771add4413a
Autor:
Tomoki Sugiyama, Tomohiro Asai, Yuki Murase Nedachi, Yasufumi Katanasaka, Kosuke Shimizu, Noriyuki Maeda, Naoto Oku
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67550 (2013)
To achieve effective active targeting in a drug delivery system, we previously developed dual-targeting (DT) liposomes decorated with both vascular endothelial growth factor receptor-1 (VEGFR-1)-targeted APRPG and CD13-targeted GNGRG peptide ligands
Externí odkaz:
https://doaj.org/article/a031c04cb50c4651a7a64b44ff7e4348
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71372 (2013)
Zinc homeostasis in the brain is associated with the etiology and manifestation of epileptic seizures. Adult Noda epileptic rats (NER, >12-week-old) exhibit spontaneously generalized tonic-clonic convulsion about once a day. To pursue the involvement
Externí odkaz:
https://doaj.org/article/8e80099a78f94e669e5961c04b0120af
Autor:
Ayaka Okamoto, Tomohiro Asai, Sho Ryu, Hidenori Ando, Noriyuki Maeda, Takehisa Dewa, Naoto Oku
Publikováno v:
Journal of Clinical Medicine, Vol 5, Iss 1, p 10 (2016)
Genetic therapy using microRNA-499 (miR-499) was combined with chemotherapy for the advanced treatment of cancer. Our previous study showed that miR-499 suppressed tumor growth through the inhibition of vascular endothelial growth factor (VEGF) produ
Externí odkaz:
https://doaj.org/article/2d9f05ceb37544e0a7fc75ba6823ce1b