Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Naoto Kosaki"'
Autor:
Takahide Tohmonda, Naoto Kosaki, Masaki Yoda, Hironari Takaishi, Kazuhiro Chiba, Norikazu Ota, Kosuke Tajima, Keisuke Horiuchi, Toshiyasu Nakamura, Morio Matsumoto, Tokuhiro Kimura, Hiroyasu Ikegami, Yoshiaki Toyama, Jiro Takito, Yasunori Okada
Publikováno v:
Journal of Orthopaedic Research. 28:937-941
Skeletal fracture healing involves a variety of cellular and molecular events; however, the mechanisms behind these processes are not fully understood. In the current study, we investigated the potential involvement of the signal transducer and activ
Autor:
Naoto Kosaki, Yasunari Takada, Nobuhito Nango, Yoshiaki Toyama, Koichi Matsuo, Yoshinori Arai, Hironari Takaishi, Kenta Maruyama, Kouji Shimoda, Toru Yamaguchi
Publikováno v:
Journal of Bone and Mineral Research. 24:2056-2065
Inflammation inevitably follows injury of various tissues, including bone. Transgenic overexpression of Fra-1, a component of the transcription factor activator protein-1 (AP-1), in various tissues progressively and globally enhances bone formation,
Autor:
Hisataka Yasuda, Tokuhiro Kimura, Hiroshi Kawaguchi, Norikazu Ota, Masaki Yoda, Kazuhiro Chiba, Morio Matsumoto, Hironari Takaishi, Takahide Tohmonda, Hiroyasu Ikegami, Jiro Takito, Naoto Kosaki, Yoshiaki Toyama, Yasunori Okada
Publikováno v:
Endocrinology. 150:4823-4834
Receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG), a decoy receptor of RANKL, maintain bone mass by regulating the differentiation of osteoclasts, which are bone-resorbing cells. Endochondral bone ossification and b
Autor:
Takeshi Miyamoto, Yoshiaki Toyama, Naoto Kosaki, Keisuke Horiuchi, Jiro Takito, Akihiro Hakozaki, Mitsuru Furukawa, Kenichiro Matsuzaki, Hironari Takaishi, Yoshiteru Miyauchi, Hideo Morioka, Hironori Kaneko, Carl P. Blobel
Publikováno v:
Scopus-Elsevier
CSF-1 is a hemopoietic growth factor, which plays an essential role in macrophage and osteoclast development. Alternative splice variants of CSF-1 are synthesized as soluble or membrane-anchored molecules, although membrane CSF-1 (mCSF-1) can be clea
Autor:
Hironari Takaishi, Takeshi Miyamoto, Norihiro Tada, Yoshiaki Toyama, Naoto Kosaki, Yasuo Niki, Hideo Matsumoto, Jiro Takito
Publikováno v:
The Journal of Immunology. 179:639-646
IL-1α transgenic (Tg) mice exhibit chronic inflammatory arthritis and subsequent osteopenia, with IL-1-induced GM-CSF playing an important role in the pathogenesis. This study analyzed the mechanisms underlying osteopenia in Tg mice, and the therape
Autor:
Yoshiaki Toyama, Naoto Kosaki, Jeanine D'Armiento, Yasunori Okada, Hironari Takaishi, Tokuhiro Kimura, Norio Amizuka, Minqi Li, Satoru Kamekura, Ung-il Chung, Kozo Nakamura, Hiroshi Kawaguchi
Publikováno v:
Biochemical and Biophysical Research Communications. 354:846-851
Vascular and cellular invasion into the cartilage is a critical step in the fracture healing. Matrix metalloproteinase-13 (MMP-13) is a member of the zinc-dependent endopeptidase family and plays an important role in remodeling of extracellular matri
Autor:
Kosuke, Tajima, Hironari, Takaishi, Jiro, Takito, Takahide, Tohmonda, Masaki, Yoda, Norikazu, Ota, Naoto, Kosaki, Morio, Matsumoto, Hiroyasu, Ikegami, Toshiyasu, Nakamura, Tokuhiro, Kimura, Yasunori, Okada, Keisuke, Horiuchi, Kazuhiro, Chiba, Yoshiaki, Toyama
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 28(7)
Skeletal fracture healing involves a variety of cellular and molecular events; however, the mechanisms behind these processes are not fully understood. In the current study, we investigated the potential involvement of the signal transducer and activ
Autor:
Yoshiaki Toyama, Naoto Kosaki, Hideo Morioka, Yasunori Suda, Hiroyuki Enomoto, Hiroya Kanagawa, Yasuo Niki, Hideo Matsumoto
Publikováno v:
The Knee. 14(5)
Localized pigmented villonodular synovitis (LPVS) is widely accepted to frequently develop symptoms resembling internal derangement in the knee, including limitation of motion and episodes of giving way and locking. We report the case of a 31-year-ol
Publikováno v:
Skeletal radiology. 34(8)
We treated a 26-year-old man with a 19-year history of Ollier's disease. Secondary chondrosarcomas developed metachronously at four separate locations: both femora, left proximal tibia and fibular head. All four lesions were surgically excised, and e
Autor:
Eiichi Fukaya, Yasuo Yoshihara, Tomoki Kawano, Kennichi Ando, Arihiko Kanaji, Yuichiro Shiromoto, Osamu Henmi, Mitsuhiro Morita, Harumoto Yamada, Masato Nakagawa, Naoto Kosaki
Publikováno v:
Journal of Orthopaedic Science
Cementless total hip replacement (THR) is rapidly being accepted as the surgery for arthritic diseases of the hip joint. The bone-ingrowth rate in porous-type cementless implants was about 90% over 10 years after surgery, showing that biological fixa