Zobrazeno 1 - 10
of 287
pro vyhledávání: '"Naoto KUBOTA"'
Autor:
Mengjun Wang, Stephane Grauzam, Muhammed Furkan Bayram, James Dressman, Andrew DelaCourt, Calvin Blaschke, Hongyan Liang, Danielle Scott, Gray Huffman, Alyson Black, Shaaron Ochoa-Rios, David Lewin, Peggi M. Angel, Richard R. Drake, Lauren Ball, Jennifer Bethard, Stephen Castellino, Yuko Kono, Naoto Kubota, Yujin Hoshida, Lisa Quirk, Adam Yopp, Purva Gopal, Amit Singal, Anand S. Mehta
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-11 (2024)
Abstract Background Worldwide, hepatocellular carcinoma (HCC) is the second most lethal cancer, although early-stage HCC is amenable to curative treatment and can facilitate long-term survival. Early detection has proved difficult, as proteomics, tra
Externí odkaz:
https://doaj.org/article/46176303e9b94dac90d72d3c6c970e82
Autor:
Shota Okagawa, Masaji Sakaguchi, Yuma Okubo, Yuri Takekuma, Motoyuki Igata, Tatsuya Kondo, Naoki Takeda, Kimi Araki, Bruna Brasil Brandao, Wei-Jun Qian, Yu-Hua Tseng, Rohit N. Kulkarni, Naoto Kubota, C. Ronald Kahn, Eiichi Araki
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Lipodystrophy and obesity are associated with insulin resistance and metabolic syndrome accompanied by fat tissue dysregulation. Here, we show that serine protease inhibitor A1 (SerpinA1) expression in the liver is increased during recovery
Externí odkaz:
https://doaj.org/article/73c07eb1857940b0846feaa4ba14f245
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single cells, therefore inherently failing to profile transcriptome at the single-cell le
Externí odkaz:
https://doaj.org/article/05ac996894544bf4b2709ed745cccfe3
Autor:
Takayoshi Sasako, Ken Suzuki, Sara Odawara, Hirotsugu Suwanai, Naoko Akuta, Naoto Kubota, Kohjiro Ueki, Takashi Kadowaki, Toshimasa Yamauchi
Publikováno v:
Journal of Diabetes Investigation, Vol 15, Iss 6, Pp 782-785 (2024)
ABSTRACT The potential liability to hypercatabolism in lipodystrophy remains to be fully elucidated. Here we report a 28‐year‐old Japanese woman with acquired generalized lipodystrophy, who presented with recurrence of panniculitis and anemia. Af
Externí odkaz:
https://doaj.org/article/87fa652789394e52b655150cfa585357
Autor:
David Hsiehchen, Muhammad S. Beg, Radhika Kainthla, Jay Lohrey, Syed M. Kazmi, Leticia Khosama, Mary Claire Maxwell, Heather Kline, Courtney Katz, Asim Hassan, Naoto Kubota, Ellen Siglinsky, Anil K. Pillai, Hagop Youssoufian, Colleen Mockbee, Kerry Culm, Mark Uhlik, Laura Benjamin, Rolf A. Brekken, Chul Ahn, Amit G. Singal, Hao Zhu, Yujin Hoshida, Adam C. Yopp
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Immune checkpoint inhibitors targeting PD-1/L1 have modest efficacy in hepatocellular carcinoma as single agents. Targeting membranous phosphatidylserine may induce pro-inflammatory and -immune stimulating effects that enhance immunotherapy
Externí odkaz:
https://doaj.org/article/742b5357d52e4634b5aea175a59e7fba
Autor:
Kenneth K. Tanabe, David Zahrieh, Carrie A. Strand, Yujin Hoshida, Thomas J. Flotte, Gary Della’Zanna, Asad Umar, Kenneth D. Chavin, Sean Cleary, Naoto Kubota, Josep M. Llovet, Tushar Patel, Christopher Siegel, Paul J. Limburg
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 3, Pp 426-439 (2024)
Background and Aims: Effective approaches for prevention of hepatocellular carcinoma (HCC) will have a significant impact on HCC-related mortality. There are strong preclinical data and rationale to support targeting epidermal growth factor receptor
Externí odkaz:
https://doaj.org/article/b566872f2fe84a5480b71b71604039a4
Autor:
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, Takuma Nakatsuka, Ryosuke Tateishi, Miwako Kakiuchi, Shogo Yamamoto, Kenji Tatsuno, Koji Atarashi, Wataru Suda, Kenya Honda, Hiroyuki Aburatani, Toshimasa Yamauchi, Mitsuhiro Fujishiro, Tetsuo Noda, Kazuhiko Koike, Takashi Kadowaki, Kohjiro Ueki
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Diabetes is known to increase the risk of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). Here we treat male STAM (STelic Animal Model) mice, which develop diabetes, NASH and HCC associated with dysbiosis upon low-dos
Externí odkaz:
https://doaj.org/article/00518db0b90f431a9f78d36478f351e5
Autor:
Kanako Ohkuma, Mika Sawada, Masakazu Aihara, Shunsuke Doi, Rie Sekine, Satoshi Usami, Kazuhiko Ohe, Naoto Kubota, Toshimasa Yamauchi
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 8, Pp 985-993 (2023)
ABSTRACT Aim To investigate the impact of the COVID‐19 pandemic and its preventive measures on the glycemic and lipid control in people with diabetes mellitus (DM). Materials and methods We conducted this retrospective cohort study from April 2019
Externí odkaz:
https://doaj.org/article/a3f70603ee6947a7bca41f5990de8b3b
Autor:
Takanori Hayashi, Nobuhiro Wada, Tetsuya Kubota, Chie Koizumi, Yoshitaka Sakurai, Masakazu Aihara, Satoshi Usami, Toshimasa Yamauchi, Naoto Kubota
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 6, Pp 801-810 (2023)
ABSTRACT Aims/Introduction Patients with type 2 diabetes mellitus are reported to be at a high risk for sarcopenia, and are known to have a poorer sleep quality. However, the association between sleep quality and skeletal muscle in patients with type
Externí odkaz:
https://doaj.org/article/8b9fdb953a334b2caa713a3eb81f8eb4
Autor:
Mika Sawada, Kanako Ohkuma, Masakazu Aihara, Shunsuke Doi, Rie Sekine, Tetsuji Kaneko, Satoshi Iimuro, Ikuyo Ichi, Satoshi Usami, Kazuhiko Ohe, Toshimasa Yamauchi, Naoto Kubota
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 2, Pp 321-328 (2023)
ABSTRACT Aims/Introduction To evaluate the impact of the COVID‐19 pandemic on the glycemic control, eating habits, and body composition of people with diabetes mellitus; to identify the determinants of worsening glycemic control in people with diab
Externí odkaz:
https://doaj.org/article/3b506b058920418a96ab862a5acc69e2