Výsledky vyhledávání - "Naoto Hayasaka"

Akademický článek

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

Autor: Naoto Hayasaka, Arisa Hirano, Yuka Miyoshi, Isao T Tokuda, Hikari Yoshitane, Junichiro Matsuda, Yoshitaka Fukada

Publikováno v: eLife, Vol 6 (2017)

Salt-inducible kinase 3 (SIK3) plays a crucial role in various aspects of metabolism. In the course of investigating metabolic defects in Sik3-deficient mice (Sik3-/-), we observed that circadian rhythmicity of the metabolisms was phase-delayed. Sik3

Externí odkaz: https://doaj.org/article/d3c28a2e85e043ca95f53212344f5c1d

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Akademický článek

A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia.

Autor: Yuka Miyoshi, Yoshichika Yoshioka, Kinuko Suzuki, Taisuke Miyazaki, Minako Koura, Kazumasa Saigoh, Naoko Kajimura, Yoko Monobe, Susumu Kusunoki, Junichiro Matsuda, Masahiko Watanabe, Naoto Hayasaka

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e107867 (2014)

Spinocerebellar degenerations (SCDs) are a large class of sporadic or hereditary neurodegenerative disorders characterized by progressive motion defects and degenerative changes in the cerebellum and other parts of the CNS. Here we report the identif

Externí odkaz: https://doaj.org/article/6815fa0a1e604c75af83501a9f3eabbe

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Akademický článek

In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and stroke.

Autor: Naoto Hayasaka, Nobuo Nagai, Naoyuki Kawao, Atsuko Niwa, Yoshichika Yoshioka, Yuki Mori, Hiroshi Shigeta, Nobuo Kashiwagi, Masaaki Miyazawa, Takao Satou, Hideaki Higashino, Osamu Matsuo, Takamichi Murakami

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e32342 (2012)

BackgroundThere is an increasing need for animal disease models for pathophysiological research and efficient drug screening. However, one of the technical barriers to the effective use of the models is the difficulty of non-invasive and sequential m

Externí odkaz: https://doaj.org/article/7bd320566cff43028d230c3d26a5c7b4

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Akademický článek

Quantitative analysis of phase wave of gene expression in the mammalian central circadian clock network.

Autor: Hirokazu Fukuda, Isao Tokuda, Seiichi Hashimoto, Naoto Hayasaka

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23568 (2011)

BACKGROUND: The suprachiasmatic nucleus (SCN), the master circadian clock, is a heterogeneous oscillator network, yet displays a robust synchronization dynamics. Recent single-cell bioluminescent imaging revealed temporal gradients in circadian clock

Externí odkaz: https://doaj.org/article/d4407725754244078b7e10cef8a13491

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Akademický článek

Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.

Autor: Naoto Hayasaka, Kazuyuki Aoki, Saori Kinoshita, Shoutaroh Yamaguchi, John K Wakefield, Sachiyo Tsuji-Kawahara, Kazumasa Horikawa, Hiroshi Ikegami, Shigeharu Wakana, Takamichi Murakami, Ram Ramabhadran, Masaaki Miyazawa, Shigenobu Shibata

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17655 (2011)

Regulators of G protein signaling (RGS) are a multi-functional protein family, which functions in part as GTPase-activating proteins (GAPs) of G protein α-subunits to terminate G protein signaling. Previous studies have demonstrated that the Rgs16 t

Externí odkaz: https://doaj.org/article/0a6ba11143594b51b025d1b979eec38c

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Akademický článek

Differential contribution of rod and cone circadian clocks in driving retinal melatonin rhythms in Xenopus.

Autor: Naoto Hayasaka, Silvia I LaRue, Carla B Green

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15599 (2010)

Although an endogenous circadian clock located in the retinal photoreceptor layer governs various physiological events including melatonin rhythms in Xenopus laevis, it remains unknown which of the photoreceptors, rod and/or cone, is responsible for

Externí odkaz: https://doaj.org/article/74a4c3404dc943449ec0ece2ab368c80

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