Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Naoto Arimura"'
Autor:
Shuuichi Miyakawa, Hiroyuki Sakuma, Dnyaneshwar Warude, Satomi Asanuma, Naoto Arimura, Tomoki Yoshihara, Daniel Tavares, Akito Hata, Koh Ida, Yuri Hori, Yuumi Okuzono, Syunsuke Yamamoto, Koichi Iida, Hisao Shimizu, Shinichi Kondo, Shuji Sato
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying
Externí odkaz:
https://doaj.org/article/1bfd1d0933a04c75b1f1c53ea0ed5fe5
Autor:
Yu Takahashi, Akihiro Shinoda, Norihiko Furuya, Eri Harada, Naoto Arimura, Ikuyo Ichi, Yoko Fujiwara, Jun Inoue, Ryuichiro Sato
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64605 (2013)
Sterol regulatory element-binding protein-1 (SREBP-1) has been thought to be a critical factor that assists adipogenesis. During adipogenesis SREBP-1 stimulates lipogenic gene expression, and peroxisome proliferator-activated receptor γ (PPARγ) enh
Externí odkaz:
https://doaj.org/article/b7f03d56cf454dc59cd10377c7b4df8e
Autor:
Zenichi Ikeda, Taku Kamei, Yusuke Sasaki, Matthew Reynolds, Nozomu Sakai, Masato Yoshikawa, Michiko Tawada, Nao Morishita, Douglas R. Dougan, Chien-Hung Chen, Irena Levin, Hua Zou, Masako Kuno, Naoto Arimura, Yusuke Kikukawa, Mitsuyo Kondo, Kimio Tohyama, Kenjiro Sato
Publikováno v:
Journal of Medicinal Chemistry. 66:6354-6371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::079b3ce7aa41ba52a2e07271c1b47339
https://doi.org/10.1021/acs.jmedchem.3c00348
https://doi.org/10.1021/acs.jmedchem.3c00348
Autor:
Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Kotaro Yoshioka, Naoto Arimura, Takanori Yokota, Frank Rigo, Toshiki Uchihara, Takashi Ishii, Kensuke Ihara, Kenichi Miyata, Haruka Miyata, Takeshi Wada, Kanjiro Miyata, Chrissa A. Dwyer, Punit P. Seth, Tetsuya Nagata, Rintaro Iwata Hara, Syunsuke Yamamoto, Hideki Hirabayashi, Satoe Ebihara, Tomoko Igari, C. Frank Bennett, Masaki Ohyagi, Berit Powers
Publikováno v:
Nature Biotechnology. 39:1529-1536
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dbc680bd2292680a38bb270a82d4
https://doi.org/10.1038/s41587-021-00972-x
https://doi.org/10.1038/s41587-021-00972-x
Autor:
Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara, Masataka Murakami, Minoru Nakamura, Yuya Oguro, Jumpei Aida, Nao Morishita, Satoshi Sogabe, Douglas R. Dougan, Sean C. Gay, Ling Qin, Naoto Arimura, Yasuko Takahashi, Masako Sasaki, Yusuke Kamada, Kazunobu Aoyama, Kouya Kimoto, Makoto Kamata
Publikováno v:
Journal of Medicinal Chemistry. 64:11014-11044
The therapeutic potential of monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases has attracted attention worldwide. However, the availability of reversible-type inhibitor is still limited to clarify the pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cd4fa7ad8b972d705a7447e0aa09299
https://doi.org/10.1021/acs.jmedchem.1c00432
https://doi.org/10.1021/acs.jmedchem.1c00432
Autor:
Masayuki Fujinaga, Jun Maeda, Makoto Higuchi, Yasuko Takahashi, Kazunori Kawamura, Naoto Arimura, Chie Seki, Masako Sasaki, Tatsuki Koike, Kazunobu Aoyama, Yasushi Hattori, Ming-Rong Zhang, Tomoteru Yamasaki, Yuji Nagai
Publikováno v:
Journal of Medicinal Chemistry. 62:2362-2375
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase involved in endocannabinoid and inflammatory signaling. Positron-emission tomography (PET) imaging of MAGL serves to validate target engagement of therapeutic MAGL inhibitors as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa83f77c76dce1844c62efe34368b7c
https://doi.org/10.1021/acs.jmedchem.8b01576
https://doi.org/10.1021/acs.jmedchem.8b01576
Autor:
Shuji Sato, Yuumi Okuzono, Tomoki Yoshihara, Akito Hata, Hiroyuki Sakuma, Shuuichi Miyakawa, Koh Ida, Koichi Iida, Naoto Arimura, Dnyaneshwar Warude, Syunsuke Yamamoto, Daniel Tavares, Shinichi Kondo, Hisao Shimizu, Yuri Hori, Satomi Asanuma
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience, Vol 14 (2020)
Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN levels could have promising therapeutic implications for patients carrying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ce6d69f0613c05db94c688983ae4f3
https://pubmed.ncbi.nlm.nih.gov/33384578
https://pubmed.ncbi.nlm.nih.gov/33384578
Autor:
Yasushi, Hattori, Kazunobu, Aoyama, Jun, Maeda, Naoto, Arimura, Yasuko, Takahashi, Masako, Sasaki, Masayuki, Fujinaga, Chie, Seki, Yuji, Nagai, Kazunori, Kawamura, Tomoteru, Yamasaki, Ming-Rong, Zhang, Makoto, Higuchi, Tatsuki, Koike
Publikováno v:
Journal of medicinal chemistry. 62(5)
Monoacylglycerol lipase (MAGL) is a cytosolic serine hydrolase involved in endocannabinoid and inflammatory signaling. Positron-emission tomography (PET) imaging of MAGL serves to validate target engagement of therapeutic MAGL inhibitors as well as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7fbd25c020cd5b134c6040b33fb1742
https://pubmed.ncbi.nlm.nih.gov/30753069
https://pubmed.ncbi.nlm.nih.gov/30753069
Autor:
Satoshi Sogabe, Shuhei Ikeda, Makoto Fushimi, Tomokazu Kusumoto, Naoto Arimura, Tatsuki Koike, Hideyuki Sugiyama, Jumpei Aida, Kazunobu Aoyama, Masako Sasaki
Publikováno v:
Journal of medicinal chemistry. 61(20)
Monoacylglycerol lipase (MAGL) is a major serine hydrolase that hydrolyzes 2-arachidonoylglycerol (2-AG) to arachidonic acid (AA) and glycerol in the brain. Because 2-AG and AA are endogenous biologically active ligands in the brain, inhibition of MA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbac7b30fa3489c39d55272bb78fbdc
https://pubmed.ncbi.nlm.nih.gov/30251836
https://pubmed.ncbi.nlm.nih.gov/30251836
Autor:
Yoshiaki Horiguchi, Kenneth A. Bragstad, Clifford D. Mol, Tsuyoshi Maekawa, Junichi Sakamoto, Takeshi Wakabayashi, Nozomi Katayama, Chisako Nomura, Mitsuharu Matsumoto, Hidenori Abe, Kentaro Rikimaru, Miyuki Funami, Takanori Matsuo, Kazutoshi Kawakami, Hiroko Tsuge, Katsuhito Murase, Bi-Ching Sang, Gyorgy Snell, Hiroshi Imoto, Naoto Arimura, Osamu Ujikawa, Toshimasa Tanaka, Douglas R. Dougan, Yu Momose
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:714-733
Herein, we describe the design, synthesis, and structure–activity relationships of novel benzylpyrazole acylsulfonamides as non-thiazolidinedione (TZD), non-carboxylic-acid-based peroxisome proliferator-activated receptor (PPAR) γ agonists. Dockin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::764453c6f03ec0477f15c055aea564ba
https://doi.org/10.1016/j.bmc.2011.12.008
https://doi.org/10.1016/j.bmc.2011.12.008