Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Naotaro Akiyama"'
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 3, Pp 730-739 (2022)
Abstract Objectives The epidermal growth factor receptor (EGFR) is related to the invasion and metastasis of external auditory canal (EAC) squamous cell carcinoma (SCC). The phosphoinositide‐dependent protein kinase‐1 (PDPK1) accelerates tumor ce
Externí odkaz:
https://doaj.org/article/a6f415ff97aa4bc1918c00b599f50c1e
Autor:
Tomomi, Yamamoto-Fukuda, Naotaro, Akiyama, Motoki, Hirabayashi, Hajime, Shimmura, Hiromi, Kojima
Publikováno v:
Otology & Neurotology. 44:273-280
To evaluate the effectiveness of the menin-MLL inhibitor, MI503, as a conservative treatment of middle ear cholesteatoma (cholesteatoma) in a mouse model and to confirm its safety profile regarding auditory function in vivo.Cholesteatoma is a mass fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3fcbddd2db3550f143f58bf1d32142
https://doi.org/10.1097/mao.0000000000003795
https://doi.org/10.1097/mao.0000000000003795
Publikováno v:
The American Journal of Pathology. 192:1573-1591
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08c517202bb599f3be3322c1d9c6d3a
https://doi.org/10.1016/j.ajpath.2022.07.010
https://doi.org/10.1016/j.ajpath.2022.07.010
Publikováno v:
Acta oto-laryngologica. 142(6)
External auditory canal (EAC) squamous cell carcinoma (SCC) is a rare disease, and the survival rate is low in the advanced stages. It has been reported that miR-34a expression is low in many cancers and acts as a tumor suppressor, but its function i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134d14870064bf8cafd3deb23f467eec
https://pubmed.ncbi.nlm.nih.gov/35732008
https://pubmed.ncbi.nlm.nih.gov/35732008
Publikováno v:
The American Journal of Pathology. 190:1667-1679
Middle-ear cholesteatoma (cholesteatoma) is a chronic otitis media with an enhanced proliferation of epithelial cells. Negative pressure in the middle ear is thought to be important for the etiology of cholesteatoma. However, the mechanism of cholest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c677fe517e11e6624fd8cf7c7a3d4bce
https://doi.org/10.1016/j.ajpath.2020.04.007
https://doi.org/10.1016/j.ajpath.2020.04.007
Autor:
Natsuki Inoue, Toshiki Kubota, Shouko Morozumi, Yuichiro Yokoi, Yusuke Sakaguchi, Mamoru Yoshikawa, Yuka Aoki, Daiya Asaka, Naotaro Akiyama
Publikováno v:
Nippon Jibiinkoka Gakkai Kaiho. 122:1528-1535
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0380628def4f707a15fec55f3fb6f91e
https://doi.org/10.3950/jibiinkoka.122.1528
https://doi.org/10.3950/jibiinkoka.122.1528
Autor:
Masahiro Takahashi, Tomomi Yamamoto-Fukuda, Hiromi Kojima, Naotaro Akiyama, Yasuhiro Tanaka, Masaomi Motegi, Yutaka Yamamoto, Kazuhisa Yamamoto
Publikováno v:
Otology & Neurotology. 40:e803-e811
INTRODUCTION Partial epithelial-mesenchymal transition (p-EMT) is a process by which epithelial cells partially lose their intercellular adhesion and change to obtain migration ability. The transcription factor p63 regulates the expression of cadheri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcae1388b2862ab39a1b60700a7100d8
https://doi.org/10.1097/mao.0000000000002328
https://doi.org/10.1097/mao.0000000000002328
Publikováno v:
J Assoc Res Otolaryngol
Distinct histone modifications regulate gene expression in certain diseases, but little is known about histone epigenetics in middle ear cholesteatoma. It is known that histone acetylation destabilizes the nucleosome and chromatin structure and induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7cf6bf9d923baf2660d307bb2caae2
https://pubmed.ncbi.nlm.nih.gov/33861394
https://pubmed.ncbi.nlm.nih.gov/33861394
Publikováno v:
Current opinion in otolaryngologyhead and neck surgery. 28(5)
PURPOSE OF REVIEW Middle ear cholesteatoma is an epithelial lesion that expands into the middle ear, resulting in bone destruction. However, the pathogenesis of this has been unknown. The purpose of this review is to understand the role of keratinocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc19747b13b6366aea17a9baab367bb
https://pubmed.ncbi.nlm.nih.gov/32796271
https://pubmed.ncbi.nlm.nih.gov/32796271
Publikováno v:
Acta Oto-Laryngologica. 137:1158-1165
Mechanotransduction plays an important role in cell-proliferative activities. Negative pressure in the middle ear is thought to be an important factor related to the etiology of acquired middle ear cholesteatoma. However, the correlation between nega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fce1f5e77fb5c1f036c4bfdb97fd1e9
https://doi.org/10.1080/00016489.2017.1351040
https://doi.org/10.1080/00016489.2017.1351040