Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Naotaka Izuo"'
Autor:
Naotaka Izuo, Hajime Miyanishi, Daisuke Nishizawa, Takuma Fujii, Junko Hasegawa, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Atsumi Nitta
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 4, Pp 570-575 (2023)
Abstract Aims Cigarette smoking is a preventable risk factor for various diseases such as cancer, ischemic stroke, cardiac stroke, and chronic obstructive pulmonary disease. Smoking cessation is of great importance not only for individual smokers but
Externí odkaz:
https://doaj.org/article/56dcf0fd166b4a778b918d1fa292bc06
Autor:
Takashi Asano, Hiroki Takemoto, Tomoya Horita, Tomohiro Tokutake, Naotaka Izuo, Takatoshi Mochizuki, Atsumi Nitta
Publikováno v:
Neuropsychopharmacology Reports, Vol 43, Iss 4, Pp 505-512 (2023)
Abstract Cannabis withdrawal syndrome (CWS) in humans is characterized by various somatic symptoms, including sleep disturbances. In the present study, we investigated sleep alterations in mice after the cessation of arachidonylcyclopropylamide (ACPA
Externí odkaz:
https://doaj.org/article/74f758ae35bc4a98aadbbcb213027eae
Autor:
Yayoi Obata, Kazuma Murakami, Taiji Kawase, Kenji Hirose, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie
Publikováno v:
ACS Omega, Vol 5, Iss 34, Pp 21531-21537 (2020)
Externí odkaz:
https://doaj.org/article/fb417b04a9af4aa3b1597a9b183e48de
Autor:
Shuichi Shibuya, Yusuke Ozawa, Kenji Watanabe, Naotaka Izuo, Toshihiko Toda, Koutaro Yokote, Takahiko Shimizu
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109288 (2014)
Cu-Zn superoxide dismutase (Sod1) loss causes a redox imbalance as it leads to excess superoxide generation, which results in the appearance of various aging-related phenotypes, including skin atrophy. Noble metal nanoparticles, such as palladium (Pd
Externí odkaz:
https://doaj.org/article/754e9cab445341f690c3e44d42b0a42d
Autor:
Takayuki Suzuki, Kazuma Murakami, Naotaka Izuo, Toshiaki Kume, Akinori Akaike, Tetsu Nagata, Tomoyuki Nishizaki, Takami Tomiyama, Hiroshi Takuma, Hiroshi Mori, Kazuhiro Irie
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
Oligomers of 40- or 42-mer amyloid β-protein (Aβ40, Aβ42) cause cognitive decline and synaptic dysfunction in Alzheimer's disease. We proposed the importance of a turn at Glu22 and Asp23 of Aβ42 to induce its neurotoxicity through the formation o
Externí odkaz:
https://doaj.org/article/7c5c3dd3112142f4b7b68ee4098cb8b4
Autor:
Tomohiro Tokutake, Takashi Asano, Hajime Miyanishi, Shigetoshi Nakaya, Naotaka Izuo, Atsumi Nitta
Publikováno v:
Neurochemical Research. 47:2899-2908
The number of cannabis users is increasing in the world. However, the mechanisms involved in the psychiatric effects and addiction formation remain unclear. Medical treatments against cannabis addiction have not yet been established. Δ9-Tetrahydroca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b971dde20d0cdaab7f6445bb63c3b2e
https://doi.org/10.1007/s11064-022-03708-8
https://doi.org/10.1007/s11064-022-03708-8
Publikováno v:
Neurochemical Research. 47:2703-2714
As the elderly population rapidly increases worldwide, the onset of cognitive dysfunction is expected to increase. Although neuronal plasticity, neurogenesis, and mitochondrial dysfunction have been reported to be involved in cognitive function, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150bc99e385dd13cddd8b36633612be0
https://doi.org/10.1007/s11064-022-03594-0
https://doi.org/10.1007/s11064-022-03594-0
Autor:
Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu, Kazuhiro Irie
Publikováno v:
RSC Chemical Biology. 3:1380-1396
We propose a site-specific inhibition of Aβ42 oligomerization by the green perilla-derived chalcone DDC, which is converted to its decomposed flavonoids (1–3) via nucleophilic aromatic substitution with water molecules, in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bd9c310dee0b44d28d9547d7ef1392
https://doi.org/10.1039/d2cb00194b
https://doi.org/10.1039/d2cb00194b
Autor:
Takahito Maki, Masahito Sawahata, Ichiro Akutsu, Shohei Amaike, Genki Hiramatsu, Daisuke Uta, Naotaka Izuo, Takahiko Shimizu, Kazuhiro Irie, Toshiaki Kume
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13259
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that requires further pathological elucidation to establish effective treatment strategies. We previously showed that amyloid β (Aβ) toxic conformer with a turn at positions 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97531a3becbc2598ebf2f849ef3f40fd
Publikováno v:
YAKUGAKU ZASSHI. 141:843-849
Development of therapeutics for Alzheimer's disease (AD) is an urgent research task. Amyloid β (Aβ) is one of the causative proteins of AD. Irie et al. identified a toxic conformer among the various structures of 42-mer Aβ (Aβ42). This conformer,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a0b6d6cd0be4474cfebeb0de38c166
https://doi.org/10.1248/yakushi.20-00251-5
https://doi.org/10.1248/yakushi.20-00251-5