Zobrazeno 1 - 10 of 88 pro vyhledávání: '"Naosuke, MATSUURA"'
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Akademický článek
Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal-Regulated Kinase
Autor: Yoshihisa Nozawa, Katsushi Nishihara, Yushiro Akizawa, Naoki Orimoto, Motoko Nakano, Tatsuya Uji, Hirofusa Ajioka, Atsuhiro Kanda, Naosuke Matsuura, Mamoru Kiniwa
Publikováno v: Journal of Pharmacological Sciences, Vol 94, Iss 3, Pp 233-239 (2004)
Helicobacter pylori (H. pylori) infection of gastric epithelial cells has been shown to induce interleukin (IL)-8 production, but the signal transduction mechanism leading to IL-8 production has not been clearly defined. Here, we investigate the role
Externí odkaz: https://doaj.org/article/c0ee49110b3245af8e397cc0ff5cb874
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2
Optimal Lipophilicity of Sulfonium p-Toluenesulfonate as Anti-allergic Drug
Autor: Mitsugi Yasumoto, Yukio Tada, Ichiro Yamawaki, Naosuke Matsuura, Mikio Hori, Shuichi Ueda, Hiroshi Matsumoto, Akihide Koda
Publikováno v: Chem-Bio Informatics Journal. 12:25-38
In the development of the anti-allergic drug Suplatast Tosilate (IPD-1151T) we have reported the QSAR analysis using only the calculated values, because the few logK values of sulfonium compounds had been measured till then. In this study, we m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccb6b87a0f67bcdc8aa5c2277a2ea1d0
https://doi.org/10.1273/cbij.12.25
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4
Lafutidine inhibits Helicobacter pylori-induced interleukin-8 production in human gastric epithelial cells
Autor: Motoko Nakano, Yoshihisa Nozawa, Katsushi Nishihara, Yushiro Akizawa, Mamoru Kiniwa, Atsuhiro Kanda, Tatsuya Uji, Naosuke Matsuura, Naoki Orimoto, Hirofusa Ajioka
Publikováno v: Journal of Gastroenterology and Hepatology. 19:506-511
Background and Aim: Attachment of Helicobacter pylori to gastric epithelial cells leads to the production of chemokines, such as interleukin-8 (IL-8), which in turn activate and recruit neutrophils to the site of infection. Lafutidine [(+/–)-2-(fur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b1f8008838b264438bb6873364d1ff
https://doi.org/10.1111/j.1440-1746.2003.03330.x
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5
Protein Kinase C Activation by Helicobacter pylori in Human Gastric Epithelial Cells Limits Interleukin-8 Production Through Suppression of Extracellular Signal-Regulated Kinase
Autor: Naosuke Matsuura, Naoki Orimoto, Hirofusa Ajioka, Mamoru Kiniwa, Katsushi Nishihara, Motoko Nakano, Atsuhiro Kanda, Yoshihisa Nozawa, Yushiro Akizawa, Tatsuya Uji
Publikováno v: Journal of Pharmacological Sciences, Vol 94, Iss 3, Pp 233-239 (2004)
Helicobacter pylori (H. pylori) infection of gastric epithelial cells has been shown to induce interleukin (IL)-8 production, but the signal transduction mechanism leading to IL-8 production has not been clearly defined. Here, we investigate the role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3239d6f106f9eb137e7fab74abdf5ee1
https://doi.org/10.1254/jphs.94.233
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7
Anti-hyperlipidemic action of a newly synthesized benzoic acid derivative, S-2E
Autor: Mamoru Kiniwa, Akio Yasuda, Naosuke Matsuura, Koichi Ohmori, Akira Yamamoto, Haruo Yamada
Publikováno v: European Journal of Pharmacology. 471:69-76
A newly synthesized benzoic acid derivative, (+)-(S)-p-[1-(p-tert-butylphenyl)-2-oxo-4-pyrrolidinyl]methoxybenzoic acid (S-2E), has the capacity to inhibit the biosynthesis of both sterol and fatty acids. Here, we report the mechanism by which S-2E l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aca23d07c6faed1915a94fe7ebbf53
https://doi.org/10.1016/s0014-2999(03)01793-x
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8
Lead Optimization of Dimethyl(2-phenoxyethyl)sulfonium p-Toluenesulfonate for the Development of an Anti-allergic Agent
Autor: Mitsugi Yasumoto, Naosuke Matsuura, Shuichi Ueda, Ichiro Yamawaki, Yukio Tada, Mikio Hori, Akihide Koda, Hiroshi Matsumoto
Publikováno v: Chem-Bio Informatics Journal. 3:163-174
Derivatives of dimethy-2-phenoxyethylsulfonium p-toluenesulfonate (1) were evaluated for anti-allergic activity to develop the drug for treatment of type I allergic diseases as a lead optimization step. The IgE-induced passive cutaneous anaphylaxis (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e99a0970f0e050a00ccb26c43ea72eb1
https://doi.org/10.1273/cbij.3.163
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9
Effect of lafutidine on CGRP release from cultured rat dorsal root ganglion cells
Autor: Katsushi Nishihara, Yoshihisa Nozawa, Atsuhiro Kanda, Motoko Nakano, Naosuke Matsuura, Hirofusa Ajioka, Hidekazu Miyake
Publikováno v: InflammoPharmacology. 10:505-514
Lafutidine increased capsaicin-stimulated CGRP release from isolated rat stomach without changing basal CGRP levels. In order to clarify the mechanism of this effect, we used cultured rat DRG cells and measured CGRP release. (1) DRG cells were treate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f19133b47771276558458b14bbb16bc6
https://doi.org/10.1163/156856002321544963
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10
High quality of ulcer healing in rats by lafutidine, a new-type histamine H2-receptor antagonist: involvement of capsaicin-sensitive sensory neurons
Autor: Hidekazu Miyake, Naosuke Matsuura, Hirofusa Ajioka
Publikováno v: InflammoPharmacology. 10:483-493
This study was conducted to determine whether the low recurrence rate of ulcers after treatment with lafutidine, an antiulcer drug possessing both an antisecretory and gastroprotective activities, was mediated by capsaicin-sensitive sensory neurons (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7da0cec70360f8658c6762e5723d28d
https://doi.org/10.1163/156856002321544945
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