Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Naomi Walsh"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers worldwide, and survival rates have barely improved in decades. In the era of precision medicine, treatment strategies tailored to disease mutations have revolutionized cancer t
Externí odkaz:
https://doaj.org/article/28738871203846ffaf1cce2bf004e5c3
Autor:
Charlotte Andrieu, Niamh McNamee, Anne-Marie Larkin, Alanna Maguire, Roopika Menon, Judith Mueller-Eisert, Noel Horgan, Susan Kennedy, Giuseppe Gullo, John Crown, Naomi Walsh
Publikováno v:
Medical Sciences, Vol 10, Iss 2, p 26 (2022)
Molecular and histopathological analysis of melanoma subtypes has revealed distinct epidemiological, genetic, and clinical features. However, immunotherapy for advanced metastatic melanoma patients does not differ based on subtype. Response to immune
Externí odkaz:
https://doaj.org/article/3453e78c93ba4a72b2f1c7a5332b0f8d
Autor:
Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon, Naomi Walsh, William M Gallagher, Radoslaw Zagozdzon, William R Watson, Norma O’Donovan, John Crown
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to the drug. Induction of
Externí odkaz:
https://doaj.org/article/5de7181f330d45b98eeaa2bf7e64c819
Autor:
Rachael Stolzenberg-Solomon, Alison P. Klein, Kai Yu, Harvey A. Risch, Brian M. Wolpin, Gloria M. Petersen, Donghui Li, Laufey T. Amundadottir, Eric J. Duell, Jianxin Shi, Anne Zeleniuch-Jacquotte, Herbert Yu, Lynne R. Wilkens, Nicolas Wentzensen, Xiaoliang Wang, Jean Wactawski-Wende, Ian M. Thompson, Debra T. Silverman, Howard D. Sesso, Nathaniel Rothman, Francisco X. Real, Kari G. Rabe, Miquel Porta, Ann L. Oberg, Kimmie Ng, Neil Murphy, Roger L. Milne, Nuria Malats, I-Min Lee, Robert C. Kurtz, Holger Kirsten, Verena Katzke, Robert N. Hoover, Elizabeth A. Holly, Manal M. Hassan, Patricia Hartge, Thilo Hackert, Michael G. Goggins, J. Michael Gaziano, Charles S. Fuchs, Stephen J. Chanock, Peter T. Campbell, Julie E. Buring, Bas Bueno-de-Mesquita, Paul Brennan, Sonja I. Berndt, William R. Bamlet, Ana Babic, Gabriella Andreotti, Pilar Amiano, Demetrius Albanes, Wei Zheng, Emily White, Kala Visvanathan, Xiao-Ou Shu, Ghislaine Scelo, Jonas Rosendahl, Rachel E. Neale, Loic Le Marchand, Charles Kooperberg, Phyllis J. Goodman, Graham G. Giles, Steven Gallinger, Mengmeng Du, Federico Canzian, Paige Bracci, Laura E. Beane Freeman, Alan A. Arslan, Lei Song, William Wheeler, Elizabeth A. Platz, Han Zhang, Naomi Walsh, Rayjean J. Hung, Fangcheng Yuan
Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060745e934df80d975d7d6cf77dc6c81
https://doi.org/10.1158/0008-5472.c.6512056.v1
https://doi.org/10.1158/0008-5472.c.6512056.v1
Autor:
Myra E Castel, Neil T Conlon, Naomi Walsh, Irmina Diala, Lisa Eli, John Crown, Denis M Collins
Publikováno v:
Cancer Research. 82:P2-13
Introduction: Human epidermal growth factor 2 (HER2/ErbB2) is overexpressed in approximately 20% of breast cancers. The HER2-targeted tyrosine kinase inhibitors (TKIs) neratinib, lapatinib and tucatinib are all FDA-approved for the treatment of HER2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4df91be8b2d09185747f1f586e39059
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-36
https://doi.org/10.1158/1538-7445.sabcs21-p2-13-36
Autor:
Sara Noorani, Shannon R. Nelson, Neil T. Conlon, Justine Meiller, Ekaterina Shcheglova, Alice Usai, Jojanneke Stoof, Letizia Palanga, Fiona O’Neill, Sandra Roche, Maura B. Cotter, Niall Swan, Naomi Walsh
Publikováno v:
Organoids; Volume 1; Issue 2; Pages: 168-183
Pancreatic cancer is a highly lethal disease. Therapeutic resistance to chemotherapy is a major cause of treatment failure and recurrence in pancreatic cancer. Organoids derived from cancer stem cells (CSC) are promising models for the advancement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb5642f7a2d7bd2126e62834b9b9b8e
Publikováno v:
Inorganic Chemistry
The preparation of two polyarginine conjugates of the complex Os(II) [bis-(4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine)] [Os-(Rn)2]x+ (n = 4 and 8; x = 10 and 18) is reported, to explore whether the R8 peptide sequence that promotes cell upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc4e5b65805961ba1d7c8c18b2b23d2
https://doi.org/10.1021/acs.inorgchem.1c00769
https://doi.org/10.1021/acs.inorgchem.1c00769
Autor:
Denis M. Collins, Janet McCormack, Laura P. Ivers, Jose Javier Berenguer Pina, Jo Ballot, Cecily Quinn, Darko Skrobo, Alex J. Eustace, Naomi Walsh, Aurelie Fabre, John Crown
Publikováno v:
Cancer Research. 83:P5-02
Background: The “Thousand Patient HER-2 database” project at Saint Vincent’s University Hospital (SVUH) Dublin has been used to identify HER2+ BC patients with durable complete response (never relapsed) to trastuzumab-based therapy. ~10% of met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b7cf92287b075c2fb22981c927cd88
https://doi.org/10.1158/1538-7445.sabcs22-p5-02-11
https://doi.org/10.1158/1538-7445.sabcs22-p5-02-11
Autor:
Brian M. Wolpin, Fangcheng Yuan, Lynne R. Wilkens, Núria Malats, Alan A. Arslan, Verena Katzke, Charles Kooperberg, Manal M. Hassan, Kimmie Ng, Robert N. Hoover, Naomi Walsh, Nicolas Wentzensen, Bas Bueno-de-Mesquita, Rachael Z. Stolzenberg-Solomon, Sonja I. Berndt, Holger Kirsten, Alison P. Klein, Patricia Hartge, Steven Gallinger, Demetrius Albanes, Wei Zheng, Stephen J. Chanock, Federico Canzian, Ann L. Oberg, Paige M. Bracci, I-Min Lee, Kala Visvanathan, Loic Le Marchand, Herbert Yu, Ian M. Thompson, Anne Zeleniuch-Jacquotte, Eric J. Duell, Han Zhang, Jonas Rosendahl, William R. Bamlet, Paul Brennan, Rayjean J. Hung, Kari G. Rabe, Thilo Hackert, Lei Song, Xiaoliang Wang, Elizabeth A. Holly, Howard D. Sesso, Jean Wactawski-Wende, Rachel E. Neale, Laura E. Beane Freeman, Phyllis J. Goodman, Harvey A. Risch, Jianxin Shi, Charles S. Fuchs, Nathaniel Rothman, Gabriella Andreotti, Roger L. Milne, Robert C. Kurtz, Neil Murphy, Francisco X. Real, Miquel Porta, J. Michael Gaziano, William Wheeler, Pilar Amiano, Emily White, Debra T. Silverman, Ana Babic, Kai Yu, Ghislaine Scelo, Laufey T. Amundadottir, Mengmeng Du, Gloria M. Petersen, Peter T. Campbell, Xiao-Ou Shu, Graham G. Giles, Michael Goggins, Elizabeth A. Platz, Donghui Li, Julie E. Buring
Publikováno v:
Cancer Res
Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a521663213b218428a960240707ea9
https://doi.org/10.1158/0008-5472.can-20-0447
https://doi.org/10.1158/0008-5472.can-20-0447
Autor:
Simon J Furney, Charlotte Andrieu, Giuseppe Gullo, Alanna Maguire, Cecily Quinn, Naomi Walsh, John Crown, Peter O'Donovan
Publikováno v:
British Journal of Cancer
Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a538c3414a6756dc4222900594fc557
https://doi.org/10.1038/s41416-020-0999-z
https://doi.org/10.1038/s41416-020-0999-z