Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Naomi Taylor"'
Autor:
Varvara Folimonova, Xiang Chen, Hitendra Negi, Charles D. Schwieters, Jess Li, R. Andrew Byrd, Naomi Taylor, Philippe Youkharibache, Kylie J. Walters
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract T-cell therapies based on chimeric antigen receptor (CAR) targeting of a tumor-specific antigen offer hope for patients with relapsed or refractory cancers. CAR hinge and transmembrane regions link antigen recognition domains to intracellula
Externí odkaz:
https://doaj.org/article/b4c10e34cd6b426a9a8bdea815cc3474
Autor:
Josquin Moraly, Taisuke Kondo, Mehdi Benzaoui, Justyn DuSold, Sohan Talluri, Marie C. Pouzolles, Christopher Chien, Valérie Dardalhon, Naomi Taylor
Publikováno v:
Molecular Oncology, Vol 18, Iss 7, Pp 1695-1718 (2024)
Tumor‐infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T cells have demonstrated remarkable success in the treatment of relapsed/refractory melanoma and hematological malignancies, respectively. These treatments have marked a piv
Externí odkaz:
https://doaj.org/article/708332c6de7f4a75b557c9cbb7ea8d26
Autor:
Hannah W. Song, Mehdi Benzaoui, Alka Dwivedi, Sarah Underwood, Lipei Shao, Sooraj Achar, Vesna Posarac, Victoria A. Remley, Michaela Prochazkova, Yihua Cai, Ping Jin, Robert P. Somerville, David F. Stroncek, Grégoire Altan-Bonnet, Nirali N. Shah, Christopher D. Chien, Naomi Taylor, Steven L. Highfill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101171- (2024)
Chimeric antigen receptor T cells (CART) have demonstrated curative potential for hematological malignancies, but the optimal manufacturing has not yet been determined and may differ across products. The first step, T cell selection, removes contamin
Externí odkaz:
https://doaj.org/article/e203f324125d46899b74298138fef026
Autor:
Cédric Mongellaz, Rita Vicente, Lenora M. Noroski, Nelly Noraz, Valérie Courgnaud, Javier Chinen, Emilia Faria, Valérie S. Zimmermann, Naomi Taylor
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionZAP-70, a protein tyrosine kinase recruited to the T cell receptor (TCR), initiates a TCR signaling cascade upon antigen stimulation. Mutations in the ZAP70 gene cause a combined immunodeficiency characterized by low or absent CD8+ T cell
Externí odkaz:
https://doaj.org/article/9b8b9c74f3a9402ea679547b0d87cb55
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
The expansion and persistence of chimeric antigen receptor (CAR) T-cells in patients are associated with response, toxicity, and long-term efficacy. As such, the tools used to detect CAR T-cells following infusion are fundamental for optimizing this
Externí odkaz:
https://doaj.org/article/f9e49f10d3de42d1b40358e956a1a353
Autor:
Amandine Guérin, Claire Angebault, Sandrina Kinet, Chantal Cazevieille, Manuel Rojo, Jérémy Fauconnier, Alain Lacampagne, Arnaud Mourier, Naomi Taylor, Pascal de Santa Barbara, Sandrine Faure
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102431- (2022)
YAP1 and TAZ are transcriptional co-activator proteins that play fundamental roles in many biological processes, from cell proliferation and cell lineage fate determination to tumorigenesis. We previously demonstrated that Limb Expression 1 (LIX1) re
Externí odkaz:
https://doaj.org/article/5848f22909c44572a130404b7046267e
Autor:
Ira Phadke, Marie Pouzolles, Alice Machado, Josquin Moraly, Pedro Gonzalez-Menendez, Valérie S. Zimmermann, Sandrina Kinet, Mark Levine, Pierre-Christian Violet, Naomi Taylor
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Hematopoiesis, a process that results in the differentiation of all blood lineages, is essential throughout life. The production of 1x1012 blood cells per day, including 200x109 erythrocytes, is highly dependent on nutrient consumption. Notably thoug
Externí odkaz:
https://doaj.org/article/12d22429cc644009a3c92e50efd88074
Autor:
Meijie Tian, Adam T. Cheuk, Jun S. Wei, Abdalla Abdelmaksoud, Hsien-Chao Chou, David Milewski, Michael C. Kelly, Young K. Song, Christopher M. Dower, Nan Li, Haiying Qin, Yong Yean Kim, Jerry T. Wu, Xinyu Wen, Mehdi Benzaoui, Katherine E. Masih, Xiaolin Wu, Zhongmei Zhang, Sherif Badr, Naomi Taylor, Brad St. Croix, Mitchell Ho, Javed Khan
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 16 (2022)
Chimeric antigen receptor (CAR) T cell therapies targeting single antigens have performed poorly in clinical trials for solid tumors due to heterogenous expression of tumor-associated antigens (TAAs), limited T cell persistence, and T cell exhaustion
Externí odkaz:
https://doaj.org/article/114fac18c13d4632b85c061e52d66443
Autor:
Ildem Akerman, Bahar Kasaai, Alina Bazarova, Pau Biak Sang, Isabelle Peiffer, Marie Artufel, Romain Derelle, Gabrielle Smith, Marta Rodriguez-Martinez, Manuela Romano, Sandrina Kinet, Peter Tino, Charles Theillet, Naomi Taylor, Benoit Ballester, Marcel Méchali
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can b
Externí odkaz:
https://doaj.org/article/9fd4abfa0458400da994ba8ead8f7cae
Autor:
Maria I. Matias, Carmen S. Yong, Amir Foroushani, Chloe Goldsmith, Cédric Mongellaz, Erdinc Sezgin, Kandice R. Levental, Ali Talebi, Julie Perrault, Anais Rivière, Jonas Dehairs, Océane Delos, Justine Bertand-Michel, Jean-Charles Portais, Madeline Wong, Julien C. Marie, Ameeta Kelekar, Sandrina Kinet, Valérie S. Zimmermann, Ilya Levental, Laurent Yvan-Charvet, Johannes V. Swinnen, Stefan A. Muljo, Hector Hernandez-Vargas, Saverio Tardito, Naomi Taylor, Valérie Dardalhon
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109911- (2021)
Summary: Suppressive regulatory T cell (Treg) differentiation is controlled by diverse immunometabolic signaling pathways and intracellular metabolites. Here we show that cell-permeable α-ketoglutarate (αKG) alters the DNA methylation profile of na
Externí odkaz:
https://doaj.org/article/0c8c5ea249b7400aa1ce379f1a846ac3