Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Naomi T. Nkinsi"'
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
RIT1 mutations are mutually exclusive with other lung cancer drivers and lack targeted therapies. Here the authors examine genetic dependencies of mutant RIT1 with genome-wide CRISPR screens, revealing synergy between RIT1 and YAP1, and increased sen
Externí odkaz:
https://doaj.org/article/06e749d7f425413a87006cc1366f2c04
Publikováno v:
Academic Medicine. 96:1634-1637
Medical students demonstrate their passion for participating in and improving health care both within and outside the classroom. As the COVID-19 pandemic swept across the world, medical students in the United States engaged in student-led service-lea
Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer
Autor:
Natasha Rekhtman, Athea Vichas, Robert K. Bradley, Jacqueline Watson, John K. Lee, Austin M. Gabel, Marina K. Baine, Amanda K. Riley, Shriya Kamlapurkar, Federica Piccioni, James D. Thomas, Iris Fung, Naomi T. Nkinsi, Emily M. Hatch, Jennifer Chen, Marc Ladanyi, Matthew G. Rees, Fujiko Duke, April Lo, Phoebe C. R. Parrish, Alice H. Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications
CRISPR-based cancer dependency maps are accelerating advances in cancer precision medicine, but adequate functional maps are limited to the most common oncogenes. To identify opportunities for therapeutic intervention in other rarer subsets of cancer
Autor:
Emma R. Hoppe, Jacob T. Polaski, Jacqueline Watson, Robert K. Bradley, Joseph Pangallo, James D. Thomas, Alice H. Berger, Qing Feng, Naomi T. Nkinsi, Austin M. Gabel, Andrea E. Belleville, Emma De Neef, Maria McSharry
Publikováno v:
Nature genetics
While RNA-seq has enabled comprehensive quantification of alternative splicing, no correspondingly high-throughput assay exists for functionally interrogating individual isoforms. We describe pgFARM (paired guide RNAs for alternative exon removal), a
Autor:
Naomi T. Nkinsi, Bessie A. Young
Publikováno v:
Kidney360
Autor:
Amanda K. Riley, Athea Vichas, Naomi T. Nkinsi, Phoebe C. Parrish, Shriya Kamlapurkar, Alice H. Berger
Publikováno v:
Cancer Research. 82:2972-2972
Standard care of lung cancer treatment has shifted away from non-specific, cytotoxic chemotherapy in favor of targeted therapies based on genetic mutations within tumors. In 2014, somatic mutations in the small GTPase RIT1 (Ras-like in all tissues) w
Autor:
Briana Christophers, Paul D Schumann, Elizabeth Stein, Naomi T. Nkinsi, Edwin Nieblas-Bedolla
Publikováno v:
Academic medicine : journal of the Association of American Medical Colleges. 95(12)
The medical community has been complicit in legitimizing claims of racial difference throughout the history of the United States. Unfortunately, a rigorous examination of the role medicine plays in perpetuating inequity across racial lines is often m
Autor:
Alice H. Berger, Athea Vichas, Shriya Kamlapurkar, Amanda Riley, Naomi T. Nkinsi, Phoebe C. Parrish
Publikováno v:
Cancer Research. 81:2269-2269
Standard care of lung cancer is moving away from chemotherapy in favor of personalized approaches based on specific mutations in each tumor. Genome-sequencing studies have identified somatic mutations in the small GTPase RIT1 (Ras-like in all tissues
Publikováno v:
Cancer Research. 79:2726-2726
Treatment of lung cancer is evolving from standard cytotoxic to personalized treatment based on the molecular alterations unique to each patient’s tumor. In our recent work with TCGA and others, we identified somatic mutations in the gene encoding
Autor:
Cathy A. Stevens, Anita E. Beck, Nicola Foulds, Jessica X. Chong, Deborah A. Nickerson, Kati J. Buckingham, Arnaud Monteil, Małgorzata J.M. Nowaczyk, John C. Carey, Naomi T. Nkinsi, Angela E. Scheuerle, Jolien S. Klein Wassink-Ruiter, Philippe Lory, Margaret J. McMillin, Maureen Bocian, Paige Kaplan, Michael J. Bamshad, Maria Luisa Giovannucci Uzielli, Evan A. Boyle, Colby T. Marvin, Elizabeth McPherson, Jay Shendure, Chad R. Haldeman-Englert, Catherine Mercer, Kathryn M. Shively, Holly K. Tabor, Regina A. Moreno, Jose R. Armenteros, Joshua D. Smith, Raoul C.M. Hennekam, Vandana Shashi, Margaret N. Berry, Antonie D. Kline
Freeman-Sheldon syndrome, or distal arthrogryposis type 2A (DA2A), is an autosomal dominant condition caused by mutations in MYH3 and characterized by multiple congenital contractures of the face and limbs and normal cognitive development. We identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c00775b1e3df4f1f97cbead54fcb6b
https://doi.org/10.1101/013656
https://doi.org/10.1101/013656