Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Naomi S. Rajapaksa"'
Autor:
Ryan A. Altman, Annalaura Brai, Jennifer Golden, Giuseppe La Regina, Zhengqiu Li, Terry W. Moore, William C. K. Pomerantz, Naomi S. Rajapaksa, Ashley M. Adams
Publikováno v:
ACS Med Chem Lett
[Image: see text] Innovation in medicinal chemistry has been at the heart of ACS Medicinal Chemistry Letters since the journal’s founding 10 years ago. In his inaugural editorial, Editor-in-Chief Dennis Liotta laid out a vision for the journal to b
Autor:
Naomi S. Rajapaksa
Publikováno v:
ACS Medicinal Chemistry Letters. 14:535-536
Autor:
Zhiyu Huang, Yingqing Ran, Le An, Alberto Gobbi, Jonathan Maher, Claire Emson, Naomi S. Rajapaksa, Edna F. Choo, Yongsheng Chen, Steven Do, Aleksandr Kolesnikov, Ali A. Zarrin, Christine Yu, Marian C. Bryan, Joy Drobnick, Swathi Sujatha-Bhaskar, Hans Brightbill, James R. Kiefer, Jun Liang, Brent S. McKenzie, Ross Francis, John S. Wai, Patrick J. Lupardus, Kevin DeMent
Publikováno v:
ACS Med Chem Lett
[Image: see text] IRAK4 kinase activity transduces signaling from multiple IL-1Rs and TLRs to regulate cytokines and chemokines implicated in inflammatory diseases. As such, there is high interest in identifying selective IRAK4 inhibitors for the tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c741d6c5a8d5445e4411ce0bee8e8c5
https://europepmc.org/articles/PMC7073891/
https://europepmc.org/articles/PMC7073891/
Autor:
Patrick J. Lupardus, Yongsheng Chen, Naomi S. Rajapaksa, John S. Wai, Kevin DeMent, Edna F. Choo, Brent S. McKenzie, Ross Francis, Joy Drobnick, Hans Brightbill, James R. Kiefer, Willy M. Chang, Chudi Ndubaku, Alberto Gobbi, Antonio G. DiPasquale, Aleksandr Kolesnikov, Jonathan Maher, Jianwen Feng, Claire Emson, Le An, Ali A. Zarrin, Zhiyu Huang, Christine Yu, Yingqing Ran, Marian C. Bryan, Swathi Sujatha-Bhaskar
Publikováno v:
Journal of medicinal chemistry. 62(13)
A series of pyrazolopyrimidine inhibitors of IRAK4 were developed from a high-throughput screen (HTS). Modification of an HTS hit led to a series of bicyclic heterocycles with improved potency and kinase selectivity but lacking sufficient solubility
Autor:
C. Rose Kennedy, Yongho Park, Eric N. Jacobsen, Naomi S. Rajapaksa, David D. Ford, Dan Lehnherr
Publikováno v:
Journal of the American Chemical Society. 138:13525-13528
We describe the rational design of a linked, bis-thiourea catalyst with enhanced activity relative to monomeric analogues in a representative enantioselective anion-abstraction reaction. Mechanistic insights guide development of this linking strategy
Autor:
Naomi S. Rajapaksa, Marian C. Bryan
Publikováno v:
Journal of medicinal chemistry. 61(20)
Small molecule inhibitors targeting autoimmune and inflammatory processes have been an area of intense focus within academia and industry. Much of this work has been aimed at key kinases operating as central nodes in inflammatory signaling pathways.
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:126658
Multiple asthma-relevant cytokines including IL-4, IL-5, IL-13, and TSLP depend upon JAKs for signaling. JAK inhibition may, therefore, offer a novel intervention strategy for patients with disease refractory to current standards of care. Multiple sy
Publikováno v:
Organic Letters. 15:706-709
A catalytic, enantioselective synthesis of (+)-reserpine is reported. The route features a highly diastereoselective, chiral catalyst-controlled formal aza-Diels-Alder reaction between a 6-methoxytryptamine-derived dihydro-β-carboline and an enantio
Autor:
Xiaodong Lin, Naomi S. Rajapaksa
Publikováno v:
Bioactive Carboxylic Compound Classes: Pharmaceuticals and Agrochemicals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01727cda240eeb49d69f3a3f450340e3
https://doi.org/10.1002/9783527693931.ch13
https://doi.org/10.1002/9783527693931.ch13
Autor:
Eric N. Jacobsen, Naomi S. Rajapaksa
Publikováno v:
ChemInform. 45
A novel chromium(III) triflate tridentate Schiff base complex is efficiently utilized for a highly enantio- and diastereoselective transannular ketone-ene reaction of electronically unactivated keto-olefins (I) and (III) to afford enantioenriched bic