Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Naomi R. Genuth"'
Autor:
Naomi R. Genuth, Zhen Shi, Koshi Kunimoto, Victoria Hung, Adele F. Xu, Craig H. Kerr, Gerald C. Tiu, Juan A. Oses-Prieto, Rachel E. A. Salomon-Shulman, Jeffrey D. Axelrod, Alma L. Burlingame, Kyle M. Loh, Maria Barna
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How ribosomes differ in composition and function to regulate gene expression is poorly understood. Here, the authors show that ribosome composition changes during stem cell differentiation and identify a ribosomal protein that regulates production of
Externí odkaz:
https://doaj.org/article/a6cf4298de7147c5aaf405ad37df4aa1
Autor:
Daphna Rothschild, Teodorus Theo Susanto, Jeffrey P. Spence, Naomi R. Genuth, Nasa Sinnott-Armstrong, Jonathan K. Pritchard, Maria Barna
SummaryThe hundreds of copies of ribosomal-DNA genes are the dark-matter of the human genome as it is unknown whether they possess sequence variation that forms different types of ribosomes. Here, we have overcome the technical hurdle of long-read se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::495812c966b558b32398ab4fd212b272
https://doi.org/10.1101/2023.01.30.526360
https://doi.org/10.1101/2023.01.30.526360
Autor:
Naomi R, Genuth, Maria, Barna
Publikováno v:
Nature cell biology. 24(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec916d8f68e5b473235b046d3b8c81cf
https://pubmed.ncbi.nlm.nih.gov/36192632
https://pubmed.ncbi.nlm.nih.gov/36192632
Autor:
Teodorus Theo Susanto, Naomi R. Genuth, Tea Lenarčič, Nick Quade, Kotaro Fujii, Shifeng Xue, Kathrin Leppek, Maria Barna, Nenad Ban, Daniel Boehringer
Publikováno v:
Molecular Cell, 80 (6)
Mol Cell
Mol Cell
Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of multitudes of tentacle-like rRNA structures extending from the core riboso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a495b47eeafecb8c70c953ea0dc339e
https://hdl.handle.net/20.500.11850/458489
https://hdl.handle.net/20.500.11850/458489
Autor:
Maria Barna, Tea Lenarčič, Kotaro Fujii, Teodorus Theo Susanto, Naomi R. Genuth, Shifeng Xue, Kathrin Leppek, Nick Quade, Daniel Boehringer, Nenad Ban
Publikováno v:
SSRN Electronic Journal.
Ribosomes have been suggested to directly control gene regulation, however regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. Expansion segments (ESs) consist of a multitude of tentacle-like rRNA structures that extend from the core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de6edb32f0b49a0eeb54f8de1a61787e
https://doi.org/10.2139/ssrn.3634264
https://doi.org/10.2139/ssrn.3634264
Autor:
Maria Barna, Naomi R. Genuth
Publikováno v:
Nature Reviews Genetics. 19:431-452
Regulation of mRNA translation offers the opportunity to diversify the expression and abundance of proteins made from individual gene products in cells, tissues and organisms. Emerging evidence has highlighted variation in the composition and activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49f6e896e65b2f939fa21b47bddb6b4
https://doi.org/10.1038/s41576-018-0008-z
https://doi.org/10.1038/s41576-018-0008-z
Autor:
Craig H. Kerr, Gun Woo Byeon, Maria Barna, Kotaro Fujii, Naomi R. Genuth, Erin Walsh, Olena Zhulyn
Publikováno v:
Developmental Cell. 56:2928-2937.e9
Summary Although gene expression is tightly regulated during embryonic development, the impact of translational control has received less experimental attention. Here, we find that eukaryotic translation initiation factor-3 (eIF3) is required for Shh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4759a6697983a4f6fdd73cd231edf4
https://doi.org/10.1016/j.devcel.2021.10.009
https://doi.org/10.1016/j.devcel.2021.10.009
Autor:
Linda Partridge, Yingxiao Shi, Shirleen Fang, Tania F. Gendron, Lisa Nakayama, Nicholas J. Kramer, Shizuka B. Yamada, Idoia Glaria, Naomi R. Genuth, Gabriel Rocha, Maria Barna, Tai J. I. Dinger, Teresa Niccoli, Rosslyn Grosely, Aaron D. Gitler, Adrian M. Isaacs, Joseph D. Puglisi, Annora Thoeng, Justin K. Ichida, Leonard Petrucelli
Publikováno v:
Nat Neurosci
Nature neuroscience
Nature Neuroscience
Nature neuroscience
Nature Neuroscience
Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a6ec2cf192f964bb2b5ce13350b5d
https://hdl.handle.net/21.11116/0000-000B-3F43-4
https://hdl.handle.net/21.11116/0000-000B-3F43-4
The discovery of ribosome heterogeneity and its implications for gene regulation and organismal life
Autor:
Maria Barna, Naomi R. Genuth
The ribosome has recently transitioned from being viewed as a passive, indiscriminate machine to a more dynamic macromolecular complex with specialized roles in the cell. Here, we discuss the historical milestones from the discovery of the ribosome i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3191c5be460caa5e2f5dd94a5d2a84
https://europepmc.org/articles/PMC6092941/
https://europepmc.org/articles/PMC6092941/
Autor:
Zhen Shi, Naomi R. Genuth, Mary N. Teruel, Kotaro Fujii, Maria Barna, Hannes L. Röst, Kyle M. Kovary
Publikováno v:
Molecular cell. 67(1)
Emerging studies have linked the ribosome to more selective control of gene regulation. However, an outstanding question is whether ribosome heterogeneity at the level of core ribosomal proteins (RPs) exists and enables ribosomes to preferentially tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d4d6c824f314fe837b03b5aaf9c69d
https://pubmed.ncbi.nlm.nih.gov/28642386
https://pubmed.ncbi.nlm.nih.gov/28642386