Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Naomi Petersen"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
How myelin controls energy usage in different neuronal cell types remains unclear. Here, using viral tools, live imaging and ultrastructural data, the authors show that in contrast to excitatory axons interneuron myelination boosts the clustering of
Externí odkaz:
https://doaj.org/article/5cfcb6f9cc884235ae82f33f9d8813eb
Autor:
Ravi S. Narayan, Piet Molenaar, Jian Teng, Fleur M. G. Cornelissen, Irene Roelofs, Renee Menezes, Rogier Dik, Tonny Lagerweij, Yoran Broersma, Naomi Petersen, Jhon Alexander Marin Soto, Eelke Brands, Philip van Kuiken, Maria C. Lecca, Kristiaan J. Lenos, Sjors G. J. G. In ‘t Veld, Wessel van Wieringen, Frederick F. Lang, Erik Sulman, Roel Verhaak, Brigitta G. Baumert, Lucas J. A. Stalpers, Louis Vermeulen, Colin Watts, David Bailey, Ben J. Slotman, Rogier Versteeg, David Noske, Peter Sminia, Bakhos A. Tannous, Tom Wurdinger, Jan Koster, Bart A. Westerman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Drug synergies impact the efficacy of combination therapies but are difficult to identify. Here Narayan et al. describe the drug atlas, a method to predict effective drug combinations from common exclusive drug effects providing a resource for explor
Externí odkaz:
https://doaj.org/article/379bf84492484b43b2eac920159ae273
Autor:
Dario Balestra, Mattia Ferrarese, Silvia Lombardi, Nicole Ziliotto, Alessio Branchini, Naomi Petersen, Piter Bosma, Mirko Pinotti, Stan F. J. van de Graaf
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8735 (2020)
OTC splicing mutations are generally associated with the severest and early disease onset of ornithine transcarbamylase deficiency (OTCD), the most common urea cycle disorder. Noticeably, splicing defects can be rescued by spliceosomal U1snRNA varian
Externí odkaz:
https://doaj.org/article/50248ec1b1fc4dbe9b6fc0e3b5124a92
Autor:
Dario Balestra, Daniela Scalet, Mattia Ferrarese, Silvia Lombardi, Nicole Ziliotto, Chrystal C. Croes, Naomi Petersen, Piter Bosma, Federico Riccardi, Franco Pagani, Mirko Pinotti, Stan F. J. van de Graaf
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2136 (2020)
The elucidation of aberrant splicing mechanisms, frequently associated with disease has led to the development of RNA therapeutics based on the U1snRNA, which is involved in 5′ splice site (5′ss) recognition. Studies in cellular models have demon
Externí odkaz:
https://doaj.org/article/7d2b03228a504040b8b832911c05fb85
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Guus A.M.S. van Dongen, Pieter Wesseling, W. Peter Vandertop, David P. Noske, Angel M. Carcaboso, Naomi Petersen, Susanna J.E. Veringa, Viola Caretti, Carla F.M. Molthoff, Dannis G. van Vuurden, Danielle J. Vugts, A. Charlotte P. Sewing, Tonny Lagerweij, Marc H.A. Jansen
A heatmap generated using K-means clustering of expression of VEGF-A associated genes; LG-BSG samples (blue) in the disease type histology (upper legends) cluster with normal brain (purple). DIPG (red) clusters with GBM (green). DIPG (green), pHGG/GB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdb51e427760771bbe087f83ba0b370
https://doi.org/10.1158/1535-7163.22504251
https://doi.org/10.1158/1535-7163.22504251
Autor:
Esther Hulleman, Gertjan J.L. Kaspers, Guus A.M.S. van Dongen, Pieter Wesseling, W. Peter Vandertop, David P. Noske, Angel M. Carcaboso, Naomi Petersen, Susanna J.E. Veringa, Viola Caretti, Carla F.M. Molthoff, Dannis G. van Vuurden, Danielle J. Vugts, A. Charlotte P. Sewing, Tonny Lagerweij, Marc H.A. Jansen
Supplemental Figure 2: VEGF mRNA expression in DIPG in comparison to normal brain (n=31) as analyzed by R2 (R2.amc.nl), clustered by stage of disease; unknown (n=10), pretreatment (n=2) and postmortem (n=23)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3200bf734a936950db47118d68b97ac
https://doi.org/10.1158/1535-7163.22504245.v1
https://doi.org/10.1158/1535-7163.22504245.v1
Autor:
Amélie Fréal, Nora Jamann, Jolijn Ten Bos, Jacqueline Jansen, Naomi Petersen, Thijmen Ligthart, Casper C. Hoogenraad, Maarten H. P. Kole
Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d27b19a79c8799b04064281fc6b519
https://doi.org/10.1101/2022.11.09.515770
https://doi.org/10.1101/2022.11.09.515770
Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory
Autor:
GJ Schenk, S. I. de Vries, Jennifer L. Gommerman, Mohit Dubey, Stefan M. Gold, Inge Huitinga, A. Malpede, Maarten H. P. Kole, Valeria Ramaglia, Naomi Petersen, Dong-Hoon Lee, Jeroen J. G. Geurts
The complement system is implicated in synapse loss in the MS hippocampus, but the functional consequences of synapse loss remain poorly understood. Here, in post-mortem MS hippocampi with demyelination we find that deposits of the complement compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d500cb5e684f5486abec4abb48ad7db
https://doi.org/10.1101/2021.01.15.426022
https://doi.org/10.1101/2021.01.15.426022
Autor:
Piter J. Bosma, Nicole Ziliotto, Silvia Lombardi, Mattia Ferrarese, Naomi Petersen, Stan F.J. van de Graaf, Mirko Pinotti, Dario Balestra, Alessio Branchini
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 22
International journal of molecular sciences, 21(22):8735, 1-9. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 8735, p 8735 (2020)
Volume 21
Issue 22
International journal of molecular sciences, 21(22):8735, 1-9. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 8735, p 8735 (2020)
OTC splicing mutations are generally associated with the severest and early disease onset of ornithine transcarbamylase deficiency (OTCD), the most common urea cycle disorder. Noticeably, splicing defects can be rescued by spliceosomal U1snRNA varian