Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Naomi L. Cook"'
Autor:
Brunilda Balliu, Matthew Durrant, Olivia de Goede, Nathan Abell, Xin Li, Boxiang Liu, Michael J. Gloudemans, Naomi L. Cook, Kevin S. Smith, David A. Knowles, Mauro Pala, Francesco Cucca, David Schlessinger, Siddhartha Jaiswal, Chiara Sabatti, Lars Lind, Erik Ingelsson, Stephen B. Montgomery
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Abstract Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there h
Externí odkaz:
https://doaj.org/article/1842e8c1d4754a6bb67cfbd15495ae77
Autor:
Naomi L. Cook, Milos Pjanic, Andrew G. Emmerich, Abhiram S. Rao, Susanne Hetty, Joshua W. Knowles, Thomas Quertermous, Casimiro Castillejo-López, Erik Ingelsson
Publikováno v:
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome-wide association stu
Externí odkaz:
https://doaj.org/article/7ddcd7664f6b48378f482ea490b518be
Autor:
David A. Knowles, Siddhartha Jaiswal, Mauro Pala, Lars Lind, Kevin S. Smith, Nathan S. Abell, Matthew G. Durrant, David Schlessinger, Chiara Sabatti, Erik Ingelsson, Michael J. Gloudemans, Brunilda Balliu, Olivia M. De Goede, Boxiang Liu, Naomi L. Cook, Francesco Cucca, Xin Li, Stephen B. Montgomery
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-16 (2019)
Genome Biology
Genome Biology
Background Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440f174780131a7164f963c9fe6c5534
http://link.springer.com/article/10.1186/s13059-019-1840-y
http://link.springer.com/article/10.1186/s13059-019-1840-y
Autor:
Joshua W. Knowles, Xiang Zhou, Stephen B. Montgomery, Tracey McLaughlin, Myung K. Shin, Mohsen Fathzadeh, Dermot F. Reilly, Panjamaporn Sangwung, Marcus M. Seldin, Mark P. Keller, Thomas Quertermous, Yuko Tada, Indumathi Chennamsetty, Aldons J. Lusis, Jing Yang, Cliona Molony, Michael J. Gloudemans, Martin Wabitsch, Erik Ingelsson, Ivan Carcamo-Orive, Naomi L. Cook, Jiehan Li, Gerald M. Reaven, Allan Attie, Abhiram Rao
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Genetic variation in the FAM13A (Family with Sequence Similarity 13 Member A) locus has been associated with several glycemic and metabolic traits in genome-wide association studies (GWAS). Here, we demonstrate that in humans, FAM13A alleles are asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e9e62a9e9e100a17df937d215a3e39
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409711
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-409711
Autor:
Per Lundkvist, Maria J. Pereira, Lars Lind, Paul W. Franks, Jan W. Eriksson, Prasad G. Kamble, Tove Fall, Erik Ingelsson, Stefan Gustafsson, Naomi L. Cook
Publikováno v:
Upsala Journal of Medical Sciences, Vol 122, Iss 4, Pp 234-242 (2017)
Upsala Journal of Medical Sciences
Upsala Journal of Medical Sciences
Aim: To assess practical implications of genotype-based recall (GBR) studies, an increasingly popular approach for in-depth characterization of genotype–phenotype relationships. Methods: We genotyped 2500 participants from the Swedish EpiHealth coh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a97921f3614ce8bb7bb2479ee191a9
https://doi.org/10.1080/03009734.2017.1405127
https://doi.org/10.1080/03009734.2017.1405127
Autor:
Erik Ingelsson, Casimiro Castillejo-López, Abhiram Rao, Joshua W. Knowles, Naomi L. Cook, Susanne Hetty, Milos Pjanic, Andrew G. Emmerich, Thomas Quertermous
Publikováno v:
BMC Endocrine Disorders
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-11 (2019)
BMC Endocrine Disorders, Vol 19, Iss 1, Pp 1-11 (2019)
Background The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome-wide association studies (GWA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a7319345e45d8d03e4d9c74a997dca
https://doi.org/10.1186/s12902-019-0442-8
https://doi.org/10.1186/s12902-019-0442-8
Autor:
Stephen B. Montgomery, Lars Lind, Mauro Pala, Nathan S. Abell, Siddhartha Jaiswal, Matthew G. Durrant, Olivia M. De Goede, Kevin S. Smith, Chiara Sabatti, Brunilda Balliu, Michael J. Gloudemans, Erik Ingelsson, Francesco Cucca, Boxiang Liu, Naomi L. Cook, Xin Li, David Schlessinger
SummaryMolecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f17c83f21088ec8961f9b9cef9e969
Publikováno v:
Free Radical Biology and Medicine. 53:2072-2080
Zinc is an abundant cellular transition metal ion, which binds avidly to protein cysteine (Cys) and histidine (His) residues to form zinc-Cys/His clusters; these play a key role in the function of many proteins (e.g., DNA binding and repair enzymes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabbc564e5c0f8410035a6723500f978
https://doi.org/10.1016/j.freeradbiomed.2012.09.033
https://doi.org/10.1016/j.freeradbiomed.2012.09.033
Autor:
Helena M. Viola, Victor S. Sharov, Michael J. Davies, Naomi L. Cook, Livia C. Hool, Christian Schöneich
Publikováno v:
Free Radical Biology and Medicine. 52:951-961
The sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) plays a critical role in Ca(2+) homeostasis via sequestration of this ion in the sarco/endoplasmic reticulum. The activity of this pump is inhibited by oxidants and impaired in aging tissues and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1d17f77a6e0ef10ca8d6d00ffb59f6
https://doi.org/10.1016/j.freeradbiomed.2011.12.001
https://doi.org/10.1016/j.freeradbiomed.2011.12.001
Publikováno v:
Magnesium Research. 22:158S-162S
Paper presented at 12th International Magnesium Symposium held in Iasi, Romania, 22-25 September 2009 While brain free magnesium levels have been shown to decline in a number of acute and chronic brain pathologies, the mechanisms of such decline and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9801448818884df5c35970592313229
https://doi.org/10.1684/mrh.2009.0175
https://doi.org/10.1684/mrh.2009.0175