Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Naomi Kokubo"'
Autor:
Kenji Tagai, Harutsugu Tatebe, Sayo Matsuura, Zhang Hong, Naomi Kokubo, Kiwamu Matsuoka, Hironobu Endo, Asaka Oyama, Kosei Hirata, Hitoshi Shinotoh, Yuko Kataoka, Hideki Matsumoto, Masaki Oya, Shin Kurose, Keisuke Takahata, Masanori Ichihashi, Manabu Kubota, Chie Seki, Hitoshi Shimada, Yuhei Takado, Kazunori Kawamura, Ming-Rong Zhang, Yoshiyuki Soeda, Akihiko Takashima, Makoto Higuchi, Takahiko Tokuda
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/7c34e3413c9e47fabe9c650ddabe1a10
Autor:
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
Publikováno v:
NeuroImage: Clinical, Vol 41, Iss , Pp 103560- (2024)
In Alzheimer’s disease (AD), aggregated abnormal proteins induce neuronal dysfunction. Despite the evidence supporting the association between tau proteins and brain atrophy, further studies are needed to explore their link to neuronal dysfunction
Externí odkaz:
https://doaj.org/article/e8deeb2471ab4de6915f76e8acd8bb04
Autor:
Naomi Kokubo, Yuma Yokoi, Yuji Saitoh, Miho Murata, Kazushi Maruo, Yoshitake Takebayashi, Issei Shinmei, Sadanobu Yoshimoto, Masaru Horikoshi
Publikováno v:
BMC Psychiatry, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background A newer generation neuropsychological tests can take advantage of touch screen and mobile technology. We have developed a new Android application termed “User eXperience-Trail Making Test (UX-TMT)” for neurocognitive assessmen
Externí odkaz:
https://doaj.org/article/953cc5b811a74cb98273d7cd9ce624a6
A Machine Learning–Based Approach to Discrimination of Tauopathies Using [ 18 F ] PM‐PBB3 PET Images
Autor:
Hironobu Endo, Kenji Tagai, Maiko Ono, Yoko Ikoma, Asaka Oyama, Kiwamu Matsuoka, Naomi Kokubo, Kosei Hirata, Yasunori Sano, Masaki Oya, Hideki Matsumoto, Shin Kurose, Chie Seki, Hiroshi Shimizu, Akiyoshi Kakita, Keisuke Takahata, Hitoshi Shinotoh, Hitoshi Shimada, Takahiko Tokuda, Kazunori Kawamura, Ming‐Rong Zhang, Kenichi Oishi, Susumu Mori, Yuhei Takado, Makoto Higuchi
Publikováno v:
Movement Disorders. 37:2236-2246
We recently developed a positron emission tomography (PET) probe, [sup18/supF]PM-PBB3, to detect tau lesions in diverse tauopathies, including mixed three-repeat and four-repeat (3R + 4R) tau fibrils in Alzheimer's disease (AD) and 4R tau aggregates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541de0bdbbc2f5d38f9c159bc48f3f5
https://doi.org/10.1002/mds.29173
https://doi.org/10.1002/mds.29173
Autor:
Kiwamu Matsuoka, Kosei Hirata, Naomi Kokubo, Takamasa Maeda, Kenji Tagai, Hironobu Endo, Keisuke Takahata, Hitoshi Shinotoh, Maiko Ono, Chie Seki, Harutsugu Tatebe, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
BackgroundAccumulating evidence indicated decreased levels of glutamate (Glu) and N-acetylaspartate (NAA) in the posterior cingulate cortex (PCC) in Alzheimer’s disease (AD) brains. However, the levels of these metabolites in the other brain region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d271f0ae83305224aa9b4e2563b6073
https://doi.org/10.1101/2023.04.23.23288989
https://doi.org/10.1101/2023.04.23.23288989
Publikováno v:
Psychogeriatrics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db70d82329a8ca7e94aacc8a87175da0
https://doi.org/10.1111/psyg.12971
https://doi.org/10.1111/psyg.12971
Autor:
Kosei Hirata, Kiwamu Matsuoka, Kenji Tagai, Hironobu Endo, Harutsugu Tatebe, Maiko Ono, Naomi Kokubo, Asaka Oyama, Hitoshi Shinotoh, Keisuke Takahata, Takayuki Obata, Masoumeh Dehghani, Jamie Near, Kazunori Kawamura, Ming-Rong Zhang, Hitoshi Shimada, Takanori Yokota, Takahiko Tokuda, Makoto Higuchi, Yuhei Takado
ObjectiveIncreasing evidence suggests that reactive astrocytes are associated with Alzheimer’s disease (AD). However, its underlying pathogenesis remains unknown. Given the role of astrocytes in energy metabolism, reactive astrocytes may contribute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94df773e41f8b3490d69ca8af47a036e
https://doi.org/10.1101/2023.03.09.23286881
https://doi.org/10.1101/2023.03.09.23286881
Autor:
Kiwamu, Matsuoka, Kosei, Hirata, Naomi, Kokubo, Kenji, Tagai, Hironobu, Endo, Keisuke, Takahata, Hitoshi, Shinoto, Maiko, Ono, Chie, Seki, Kazunori, Kawamura, Zhang, Ming-Rong, Hitoshi, Shimada, Yuhei, Takado, Makoto, Higuchi
Glutamatergic neurons and cingulate cortices have crucial roles in the cognitive dysfunction of Alzheimer's disease (AD). This study aimed to evaluate regional vulnerabilities of the glutamatergic system in AD at the level of the cingulate gyrus in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::6473f17e78e4f9fbb37cb9491c391f96
https://repo.qst.go.jp/records/86091
https://repo.qst.go.jp/records/86091
Autor:
Kiwamu, Matsuoka, Kosei, Hirata, Naomi, Kokubo, Kenji, Tagai, Hironobu, Endo, Keisuke, Takahata, Hitoshi, Shinoto, Maiko, Ono, Chie, Seki, Kazunori, Kawamura, Zhang, Ming-Rong, Hitoshi, Shimada, Makoto, Higuchi
Objective: Despite accumulating evidence for impaired glutamatergic neurotransmission in Alzheimer’s disease (AD) brains, its significance in neurofunctional and neuropathological alterations remains elusive. The aim of this study is to evaluate th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::d36d561322bf8c94c97544916ebefd9a
https://repo.qst.go.jp/records/85539
https://repo.qst.go.jp/records/85539
Autor:
Naomi, Kokubo, Hironobu, Endo, Kenji, Tagai, Kiwamu, Matsuoka, Kosei, Hirata, Masaki, Oya, Yasunori, Sano, Shin, Kurose, Keisuke, Takahata, Hitoshi, Shinoto, Hitoshi, Shimada, Yuhei, Takado, Makoto, Higuchi
【目的】タッチパネルを用いた認知機能検査バッテリーであるUser eXperience-Trail Making Test: UX-TMTの，パーキンソン病(PD)と進行性核上性麻痺(PSP)の認知および運動機能障害検出における有用
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::c5db743e921ba46b46c3d6f290ada3bf
https://repo.qst.go.jp/records/84417
https://repo.qst.go.jp/records/84417