Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Naomi Kashima"'
Autor:
Naomi Kashima, Kanako Kimura, Natsumi Nishitani, Masako Yamaoka Endo, Yoshiyuki Fukuba, Hideaki Kashima
Publikováno v:
Nutrients, Vol 12, Iss 5, p 1249 (2020)
Suppression of oral sweet sensation (OSS) acutely reduces intake of sweet-tasting food due to lower liking. However, little is known about other physiological responses during both the prandial and postprandial phase. Here, we explored the effects of
Externí odkaz:
https://doaj.org/article/1b3c513edfc848c7aed6109e0ef47d10
Autor:
Kazuo Kubo, Takayuki Nakashima, Kaori Yagi, Katsuya Okawa, Tomoko Hamada, Yoichi Nishiya, Yuichi Matsumoto, Takamichi Imaizumi, Yukino Nosaka, Akiyo Hirose, Naomi Kashima, Daisuke Yamaguchi
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Phenotypic screening in drug discovery has been revived with the expectation of providing promising lead compounds and drug targets and improving the success rate of drug approval. However, target identification remains a major bottleneck in phenotyp
Autor:
Natsumi Nishitani, Hideaki Kashima, Masako Yamaoka Endo, Yoshiyuki Fukuba, Kanako Kimura, Naomi Kashima
Publikováno v:
Nutrients, Vol 12, Iss 1249, p 1249 (2020)
Nutrients
Volume 12
Issue 5
Nutrients
Volume 12
Issue 5
Suppression of oral sweet sensation (OSS) acutely reduces intake of sweet-tasting food due to lower liking. However, little is known about other physiological responses during both the prandial and postprandial phase. Here, we explored the effects of
Autor:
Yasuo Watanabe, Naomi Kashima, Yoshimi Maekawa, Mark A. Dickson, Shiro Akinaga, Edward A. Sausville, Gary K. Schwartz, Daisuke Nakashima, Patricia LoRusso
Publikováno v:
Cancer Science
Numerous solid tumors overexpress or have excessively activated insulin‐like growth factor receptor‐1 (IGF‐1R). We summarize preclinical studies and the first‐in‐human study of KW‐2450, an oral tyrosine kinase inhibitor with IGF‐1R and
Publikováno v:
Cancer Science. 94:821-825
We previously demonstrated that epidermal growth factor (EGF) induces a decrease in dihydropyrimidine dehydrogenase (DPD), which is the first and rate-limiting enzyme in the catabolism of 5-fluorouracil (5-FU), in EGF receptor (EGFR)-positive human S
Publikováno v:
57th International Astronautical Congress.
Autor:
Yutaka Kanda, Takeshi Takahashi, Hiroaki Nakamura, Tomoyuki Nakazato, Masayo Suzuki, Yukimasa Shiotsu, Shiro Soga, Shiro Akinaga, Naomi Kashima, Yoshimi Maekawa, Fumito Koizumi, Shinji Nara, Hiroko Takahashi, Hiroshi Umehara
Publikováno v:
Cancer Research. 71:3605-3605
KW-2450 is an orally active, multi-kinase inhibitor which inhibits both insulin-like growth factor receptor (IGF-1R) and insulin receptor (IR) with an IC50 of 7.39 nmol/L and 5.64 nmol/L, respectively. KW-2450 also exhibits inhibitory activities (>90