Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Naomi Guppy"'
Autor:
Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton, Pascal Meier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subseque
Externí odkaz:
https://doaj.org/article/028b10c801d94af293be6d1707508113
Autor:
Priya Lakshmi Narayanan, Shan E. Ahmed Raza, Allison H. Hall, Jeffrey R. Marks, Lorraine King, Robert B. West, Lucia Hernandez, Naomi Guppy, Mitch Dowsett, Barry Gusterson, Carlo Maley, E. Shelley Hwang, Yinyin Yuan
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression ar
Externí odkaz:
https://doaj.org/article/933aafb5df734dabbcabf44349806765
Autor:
Siu Man Tsang, Hyojin Kim, Erik Oliemuller, Richard Newman, Naa-Anyima Boateng, Naomi Guppy, Beatrice A. Howard
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Little is known about the role of Sox11 in the regulation of mammary progenitor cells. Sox11 is expressed by mammary bud epithelial cells during embryonic mammary gland development and is not detected in mammary epithelial cells after birth. As Sox11
Externí odkaz:
https://doaj.org/article/f2bc5b0108d0414ea87f2f845ed7b06e
Autor:
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Abstract Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreov
Externí odkaz:
https://doaj.org/article/ebe09b78de1144a5ac46382d903dbfad
Publikováno v:
Open Veterinary Journal, Vol 7, Iss 4, Pp 300-305 (2017)
The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein
Externí odkaz:
https://doaj.org/article/7e0e15936d1c45b7adb79aad388e5111
Autor:
Saira Khalique, Sarah Nash, David Mansfield, Julian Wampfler, Ayoma Attygale, Katherine Vroobel, Harriet Kemp, Richard Buus, Hannah Cottom, Ioannis Roxanis, Thomas Jones, Katharina von Loga, Dipa Begum, Naomi Guppy, Pradeep Ramagiri, Kerry Fenwick, Nik Matthews, Michael J. F. Hubank, Christopher J. Lord, Syed Haider, Alan Melcher, Susana Banerjee, Rachael Natrajan
Publikováno v:
Cancers, Vol 13, Iss 15, p 3854 (2021)
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumo
Externí odkaz:
https://doaj.org/article/4572fce1c8e0454eb8e4726155bb806e
Autor:
Krishna Kalyan Kolluri, Constantine Alifrangis, Neelam Kumar, Yuki Ishii, Stacey Price, Magali Michaut, Steven Williams, Syd Barthorpe, Howard Lightfoot, Sara Busacca, Annabel Sharkey, Zhenqiang Yuan, Elizabeth K Sage, Sabarinath Vallath, John Le Quesne, David A Tice, Doraid Alrifai, Sylvia von Karstedt, Antonella Montinaro, Naomi Guppy, David A Waller, Apostolos Nakas, Robert Good, Alan Holmes, Henning Walczak, Dean A Fennell, Mathew Garnett, Francesco Iorio, Lodewyk Wessels, Ultan McDermott, Samuel M Janes
Publikováno v:
eLife, Vol 7 (2018)
Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear de
Externí odkaz:
https://doaj.org/article/f8b56a1949f54101aa89a88d500f0a18
Autor:
Gabriele Pollara, Matthew J Murray, James M Heather, Rachel Byng-Maddick, Naomi Guppy, Matthew Ellis, Carolin T Turner, Benjamin M Chain, Mahdad Noursadeghi
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169271 (2017)
Numerous gene signatures, or modules have been described to evaluate the immune cell composition in transcriptomes of multicellular tissue samples. However, significant diversity in module gene content for specific cell types is associated with heter
Externí odkaz:
https://doaj.org/article/b6d96bebc5964668a31d80fb86bad66f
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Western blots quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d6be537882550eb523bf94f524030e
https://doi.org/10.1158/1535-7163.22521774.v1
https://doi.org/10.1158/1535-7163.22521774.v1