Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Naomi Bronkema"'
Autor:
Wenhui He, Tianling Ou, Nickolas Skamangas, Charles C. Bailey, Naomi Bronkema, Yan Guo, Yiming Yin, Valerie Kobzarenko, Xia Zhang, Andi Pan, Xin Liu, Ava E. Allwardt, Debasis Mitra, Brian Quinlan, Rogier W. Sanders, Hyeryun Choe, Michael Farzan
SUMMARYV2-glycan/apex broadly neutralizing antibodies (bnAbs) recognize a closed quaternary epitope of the HIV-1 envelope glycoprotein (Env). This closed structure is necessary to elicit apex antibodies and useful to guide maturation of other bnAb cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9973b1c5802667f29c7af056373e7463
https://doi.org/10.1101/2022.11.07.515497
https://doi.org/10.1101/2022.11.07.515497
Autor:
Christopher Chung, Ronen Marmorstein, Naomi Bronkema, Twan W Sia, YongJoon Shin, Daniel J Boehlmer, Diep Nguyen, Emily Kibby, Jeffrey O. Zhou, Ming-Ray Xu, Rajiv Potluri, Linda Yingqi Lin, Narine Vapuryan, Michael Grasso, Daniela Fera, Tiara Tillis, Caroline Burkhard, Shirley H Zeng, Elizabeth Erler, Lucila A. Acevedo
Publikováno v:
Biochemistry
In the MAPK pathway, an oncogenic V600E mutation in B-Raf kinase causes the enzyme to be constitutively active, leading to aberrantly high phosphorylation levels of its downstream effectors, MEK and ERK kinases. The V600E mutation in B-Raf accounts f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c024badb478885fafee6c2a39cd1f83
https://pubmed.ncbi.nlm.nih.gov/33272017
https://pubmed.ncbi.nlm.nih.gov/33272017
Autor:
Ming-Ray Xu, YongJoon Shin, Caroline Burkhard, Daniela Fera, Lucila A. Acevedo, Rajiv Potluri, Narine Vapuryan, Twan Sia, Naomi Bronkema, Shirley H Zeng, Linda Yingqi Lin, Jeffrey O. Zhou, Michael Grasso, Ronen Marmorstein, Diep Nguyen, Daniel J Boehlmer, Christopher Chung, Emily Kibby, Tiara Tillis, Elizabeth Erler
In the MAPK pathway, an oncogenic V600E mutation in B-Raf kinase causes the enzyme to be constitutively active, leading to aberrantly high phosphorylation levels of its downstream effectors, MEK and ERK kinases. The V600E mutation in B-Raf accounts f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c45fefe86f4aabf3ee95ce5f6229fe8
https://doi.org/10.1101/2020.07.19.211177
https://doi.org/10.1101/2020.07.19.211177
Autor:
Naomi Bronkema, S. Munir Alam, M. Anthony Moody, David C. Montefiori, Wilton B. Williams, Kartik Manne, Andrew Foulger, Victoria Stalls, Matthew S. Lee, Thomas B. Kepler, Daniela Fera, John R. Perfect, Hui Li, Mario J. Borgnia, Celia C. LaBranche, Allen L. Hsu, Michael S. Seaman, Robert Parks, Joseph R. Francica, Kevin Wiehe, Mattia Bonsignori, Peter D. Kwong, Katarzyna Janowska, Ye Zhou, Robert A. Seder, Geoffrey M. Lynn, Priyamvada Acharya, R. Ryan Meyerhoff, Robert J. Edwards, Rory Henderson, Nathan I. Nicely, Richard Laga, Kevin O. Saunders, William E. Walkowicz, Garnett Kelsoe, Katayoun Mansouri, Alberto Bartesaghi, Sampa Santra, Guillaume Stewart-Jones, George M. Shaw, Barton F. Haynes, Todd Bradley, Baptiste Aussedat
SummaryThe HIV-1 envelope (Env) is comprised by mass of over 50% glycans. A goal of HIV-1 vaccine development is the induction of Env glycan-reactive broadly neutralizing antibodies (bnAbs). The 2G12 bnAb recognizes an Env glycan cluster using a uniq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d7a6461325995b4d86f3c77c84df10
https://doi.org/10.1101/2020.06.30.178921
https://doi.org/10.1101/2020.06.30.178921
Autor:
Hui Tian, Guruprasad Ananda, Kenneth Paigen, Gregory W. Carter, Christopher L. Baker, Catrina Spruce, Naomi Bronkema, Sibongakonke Dlamini
Publikováno v:
Genes Dev
Chromatin barriers prevent spurious interactions between regulatory elements and DNA-binding proteins. One such barrier, whose mechanism for overcoming is poorly understood, is access to recombination hot spots during meiosis. Here we show that the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd979efba7fbe0be03557ff1c396c6
https://pubmed.ncbi.nlm.nih.gov/32001511
https://pubmed.ncbi.nlm.nih.gov/32001511
Autor:
Christopher L. Baker, Naomi Bronkema, Catrina Spruce, Hui Tian, Ken Paigen, Guruprasad Ananda, Sibongakonke Dlamini, Gregory W. Carter
SUMMARYChromatin barriers prevent spurious interactions between regulatory elements and DNA-binding proteins. One such barrier, whose mechanism for overcoming is poorly understood, is access to recombination hotspots during meiosis. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1282fa380944b5af797501a0c369fb8c
Autor:
Katarzyna Janowska, Guillaume Stewart-Jones, Ye Zhou, Bhavna Hora, Naomi Bronkema, Tyler Evangelous, Alberto Bartesaghi, John R. Perfect, Hui Li, Robert A. Seder, Michael S. Seaman, Celia C. LaBranche, A. Yousef Abuahmad, Jordan Sprenz, Joseph R. Francica, M. Anthony Moody, Baptiste Aussedat, S. Munir Alam, Garnett Kelsoe, Sampa Santra, Barton F. Haynes, Richard Laga, Priyamvada Acharya, Katayoun Mansouri, Daniela Fera, Victoria Stalls, Nathan I. Nicely, Margaret Deyton, Allen L. Hsu, Madison Berry, George M. Shaw, Megan Kopp, William E. Walkowicz, David C. Montefiori, Gregory D. Sempowski, Matthew S. Lee, Sophie M. C. Gobeil, Mario J. Borgnia, Todd Bradley, Thomas H. Oguin, R. Ryan Meyerhoff, Robert Parks, Kevin Wiehe, Mattia Bonsignori, Peter D. Kwong, Kartik Manne, Geoffrey M. Lynn, Rory Henderson, Robert J. Edwards, Wilton B. Williams, Andrew Foulger, Kevin O. Saunders
Publikováno v:
Cell
Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. 2G12 is a broadly neutralizing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a6c55602fcef3c8867380821339b62
http://europepmc.org/articles/PMC8135257
http://europepmc.org/articles/PMC8135257