Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Naomi Barton"'
Autor:
Ahmed Abdullah Ahmed, Shuang Chen, Maria Roman-Escorza, Richard Angell, Sally Oxenford, Matthew McConville, Naomi Barton, Mihiro Sunose, Dan Neidle, Shozeb Haider, Tariq Arshad, Stephen Neidle
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The tetrasubstituted naphthalene diimide compound QN-302 binds to G-quadruplex (G4) DNA structures. It shows high potency in pancreatic ductal adenocarcinoma (PDAC) cells and inhibits the transcription of cancer-related genes in these cells
Externí odkaz:
https://doaj.org/article/6e2ed99e2cc7475b8ea3594c22ec910c
Autor:
Thomas G Fowler, Sally Oxenford, Mihiro Sunose, Jenny Worthington, Tam Vo, Richard Angell, Saadia A. Karim, Stephen Neidle, Matthew Mcconville, Naomi Barton, Ahmed A. Ahmed, Nicole Williams, W. David Wilson, Jennifer P. Morton, Daniel E O'Flynn
Publikováno v:
ACS Med Chem Lett
[Image: see text] Targeting of genomic quadruplexes is an approach to treating complex human cancers. We describe a series of tetra-substituted naphthalene diimide (ND) derivatives with a phenyl substituent directly attached to the ND core. The lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75540ebe7ac401c6610e70891565425
https://pubmed.ncbi.nlm.nih.gov/32832034
https://pubmed.ncbi.nlm.nih.gov/32832034
Autor:
John Unitt, Hazel Hunt, Jennifer Thomas, Emily Eaton, Naomi Barton, Iain Walters, Joseph K. Belanoff, Timothy Phillips, Benoit Gourdet, Denise Swift
Publikováno v:
Journal of Medicinal Chemistry. 60:3405-3421
The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing’s syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14042718beb90b78ce455d562051169
https://doi.org/10.1021/acs.jmedchem.7b00162
https://doi.org/10.1021/acs.jmedchem.7b00162
Autor:
Hazel J, Hunt, Joseph K, Belanoff, Iain, Walters, Benoit, Gourdet, Jennifer, Thomas, Naomi, Barton, John, Unitt, Timothy, Phillips, Denise, Swift, Emily, Eaton
Publikováno v:
Journal of medicinal chemistry. 60(8)
The nonselective glucocorticoid receptor (GR) antagonist mifepristone has been approved in the U.S. for the treatment of selected patients with Cushing's syndrome. While this drug is highly effective, lack of selectivity for GR leads to unwanted side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08833913720638471624dd32a5d970fe
https://pubmed.ncbi.nlm.nih.gov/28368581
https://pubmed.ncbi.nlm.nih.gov/28368581
Autor:
Nathalie Narraidoo, Graham B. Seymour, Benjamin J. Marsh, Rupert G. Fray, Naomi Barton, William Lewis, Christopher J. Hayes
Publikováno v:
Chemical Science
We report the first synthesis of taxadiene-4(5)-epoxide, which rearranges upon acid treatment to produce products of relevance to taxol biosynthesis.
We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereo
We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340367d192efdd958049faeb81fe463c
https://pubmed.ncbi.nlm.nih.gov/29997802
https://pubmed.ncbi.nlm.nih.gov/29997802