Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Naomi Barak"'
Autor:
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517- (2020)
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions th
Externí odkaz:
https://doaj.org/article/a212af021eff409c84704cd1ec1f0308
Autor:
Niels Böhnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Günther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jörißen, Naomi Barak, Ulf Bömer, Roman C. Hillig, Uwe Eberspaecher, Jörg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Publikováno v:
Bioconjugate chemistry. 33(6)
Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a new mode of action for cancer-targeting antibody-drug conjugates (ADCs) with activity also in slowly proliferating cells. To extend the repertoire of available ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::382f52dbd2ea6891f52b4f7a2d6e442b
https://pubmed.ncbi.nlm.nih.gov/35658441
https://pubmed.ncbi.nlm.nih.gov/35658441
Autor:
Andreas Reichel, Amaury Ernesto Fernandez-Montalvan, Cornelius Trünkle, Christian Lechner, Daniel Korr, Roderich D. Süssmuth, Léa Bouché, Naomi Barak
Publikováno v:
Drug Metabolism and Disposition. 48:553-562
The unbound partition coefficient (Kpuu) allows the estimation of intracellular target exposure from free extracellular drug concentrations. Although the active mechanisms controlling Kpuu are saturable, Kpuu is commonly determined at a single concen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935e84b863f03147e39517f576bcec68
https://doi.org/10.1124/dmd.120.090563
https://doi.org/10.1124/dmd.120.090563
Autor:
Naomi Barak, Atanas Kamburov, Nina Zablowsky, Laura M. Luh, Hanna Meyer, Uwe Eberspächer, Martin Lange, Jérémie Mortier, Clara Lemos, Nico Braeuer, Thomas Markus Leissing, Patrick Steigemann, Joerg Weiske, Ralf Lesche, Michael Steckel, Holger Steuber, Carlo Stresemann, Nicolas Werbeck, Ashley Eheim, Luise Schulze, Katrin Juenemann, Knut Eis
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517-(2020)
iScience
iScience
Summary Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccfc45a184f7faf9f0cb161ae90385f
https://pubmed.ncbi.nlm.nih.gov/32927263
https://pubmed.ncbi.nlm.nih.gov/32927263
Autor:
Cornelius, Trünkle, Christian, Lechner, Daniel, Korr, Léa, Bouché, Naomi, Barak, Amaury, Fernández-Montalván, Roderich D, Süssmuth, Andreas, Reichel
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 48(7)
The unbound partition coefficient (Kp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eefe0567c7e51903640e288f55e9c2ca
https://pubmed.ncbi.nlm.nih.gov/32357973
https://pubmed.ncbi.nlm.nih.gov/32357973
Autor:
Judith Günther, Lars Linden, Nils Griebenow, Christoph Mahlert, Antje Rottmann, Markus Berger, Hilmar Weinmann, Anette Sommer, Stefanie Hammer, Carl Friedrich Nising, Niels Böhnke, Bertolt Kreft, Antje Margret Wengner, Dominik Mumber, Anja Giese, Michael Erkelenz, Simone Greven, Beatrix Stelte-Ludwig, Rudolf Beier, Ulf Bömer, Naomi Barak, Hannah Joerissen, Lisa Dietz, Sandra Berndt
Publikováno v:
Cancer Research. 80:2907-2907
Inhibition of intracellular nicotinamide phosphoribosyltransferase (NAMPT) represents a differentiated mode-of-action for tumor-targeting antibody-drug conjugates (ADCs) independent from cell proliferation. This opens up the possibility to target slo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d351ca43fee2e2807dad82c27f5a3f5e
https://doi.org/10.1158/1538-7445.am2020-2907
https://doi.org/10.1158/1538-7445.am2020-2907
Autor:
Clara D. Christ, Roman C. Hillig, Bernard Haendler, Hilmar Weinmann, Anke Mueller-Fahrnow, Naomi Barak, Markus Berger, Erik Eggert, Carlo Stresemann, Masoud Vedadi, Antonius Ter Laak, Stephan Siegel, Cora Scholten, Oleg Fedorov, Andrea Haegebarth, Amaury Ernesto Fernandez-Montalvan, Ursula Egner, Simon H. Holton, Peter Brown, Joerg Weiske, Mátyás Gorjánácz, Volker Badock, Ingo Hartung, Seong Joo Koo, Timo Stellfeld, Susanne Mueller, Kilian Huber, Cheryl H. Arrowsmith, Detlef Stoeckigt
Publikováno v:
Cancer Research. 77:5239-5239
Low reproducibility of published target validation studies as well as the frequent failure of genetic knock-down effects to phenocopy those of small molecule inhibitors have been recognized as road blocks for cancer drug discovery. Academic and indus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56594940be9cc1edaa3da3e7c254f327
https://doi.org/10.1158/1538-7445.am2017-5239
https://doi.org/10.1158/1538-7445.am2017-5239
Autor:
Jörg Weiske, Roman C. Hillig, Ingo V. Hartung, Volker Gekeler, Hilmar Weinmann, Detlef Stoeckigt, Naomi Barak, Silke Koehr, Jeffrey Mowat, Timo Stellfeld, Karl Ziegelbauer, Antonius ter Laak, Volker Badock, Clara Christ, Carlo Stresemann
Publikováno v:
Cancer Research. 75:2829-2829
SMYD2 (SET and MYND domain-containing protein 2) is a protein lysine methyltransferase (PKMT) which was initially described as a histone H3K36 and H3K4 methyltransferase involved in transcriptional regulation. SMYD2 has recently been reported to meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1acc84b0142149598be6e2585c960ce0
https://doi.org/10.1158/1538-7445.am2015-2829
https://doi.org/10.1158/1538-7445.am2015-2829