Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae and Anopheles coluzzii

Autor: Eric R. Lucas, Sanjay C. Nagi, Alexander Egyir-Yawson, John Essandoh, Samuel Dadzie, Joseph Chabi, Luc S. Djogbénou, Adandé A. Medjigbodo, Constant V. Edi, Guillaume K. Kétoh, Benjamin G. Koudou, Arjen E. Van’t Hof, Emily J. Rippon, Dimitra Pipini, Nicholas J. Harding, Naomi A. Dyer, Louise T. Cerdeira, Chris S. Clarkson, Dominic P. Kwiatkowski, Alistair Miles, Martin J. Donnelly, David Weetman

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Abstract Resistance to insecticides in Anopheles mosquitoes threatens the effectiveness of malaria control, but the genetics of resistance are only partially understood. We performed a large scale multi-country genome-wide association study of resist

Externí odkaz: https://doaj.org/article/89a3cd77c3ef4159b9624a62ccb60c14

Near-Ultraviolet Circular Dichroism and Two-Dimensional Spectroscopy of Polypeptides

Autor: Francesco Segatta, David M. Rogers, Naomi T. Dyer, Ellen E. Guest, Zhuo Li, Hainam Do, Artur Nenov, Marco Garavelli, Jonathan D. Hirst

Publikováno v: Molecules, Vol 26, Iss 2, p 396 (2021)

A fully quantitative theory of the relationship between protein conformation and optical spectroscopy would facilitate deeper insights into biophysical and simulation studies of protein dynamics and folding. In contrast to intense bands in the far-ul

Externí odkaz: https://doaj.org/article/bf74be61cf89444bb9990d79f5a5e9b8

Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector.

Autor: Brian S Mantilla, Letícia Marchese, Aitor Casas-Sánchez, Naomi A Dyer, Nicholas Ejeh, Marc Biran, Frédéric Bringaud, Michael J Lehane, Alvaro Acosta-Serrano, Ariel M Silber

Publikováno v: PLoS Pathogens, Vol 13, Iss 1, p e1006158 (2017)

Adaptation to different nutritional environments is essential for life cycle completion by all Trypanosoma brucei sub-species. In the tsetse fly vector, L-proline is among the most abundant amino acids and is mainly used by the fly for lactation and

Externí odkaz: https://doaj.org/article/b3c6cd45955e4fbeb69fe74e831ff464

Independent pathways can transduce the life-cycle differentiation signal in Trypanosoma brucei.

Autor: Balazs Szöőr, Naomi A Dyer, Irene Ruberto, Alvaro Acosta-Serrano, Keith R Matthews

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003689 (2013)

African trypanosomes cause disease in humans and livestock, generating significant health and welfare problems throughout sub-Saharan Africa. When ingested in a tsetse fly bloodmeal, trypanosomes must detect their new environment and initiate the dev

Externí odkaz: https://doaj.org/article/80c2c4c388114e0ca043abd07886144f

Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

Autor: Ali M. Al-Shahrani, Waleed S. Al-Salem, Naomi A. Dyer, Carla Solórzano, Salah M. Balghonaim, Alice Halliday, Khalid S. Alsohibany, Abdullah M. Assiri, Gareth D. Weedall, Alvaro Acosta-Serrano, Zeyad Alzeyadi, Louise A. Kelly-Hope, Ziad A. Memish, Aitor Casas-Sanchez, Mohamed H. Alzahrani, Yasser Alraey, Essam J. Alyamani

Publikováno v: Parasites & Vectors
Parasites & Vectors, Vol 12, Iss 1, Pp 1-9 (2019)
Al-Salem, W, Solórzano, C, Weedall, G, Dyer, N, Kelly-Hope, L, Casas‑Sánchez, A, Alraey, Y, Alyamani, E, Halliday, A, Balghonaim, S, Alsohibany, K, Alzeyadi, Z, Alzahrani, M, Al-Shahrani, A, Assiri, A, Memish, Z & Acosta-Serrano, A 2019, ' Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection ', Parasites and Vectors, vol. 12, no. 1, 195 . https://doi.org/10.1186/s13071-019-3453-4

Background In the Kingdom of Saudi Arabia (KSA), Leishmania major and L. tropica are the main causative agents of Old World cutaneous leishmaniasis (CL). The national CL treatment regimen consists of topical 1% clotrimazole/2% fusidic acid cream foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b21c6e73225d2ed8095ee92bba5787a
https://doi.org/10.1186/s13071-019-3453-4