Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Naomi Sakashita"'
Autor:
Cláudia Naomi Sakashita, André Sica de Campos, Salvador Antonio Mireles Sandoval, Liz Felix Greco
Publikováno v:
Educação & Sociedade, Vol 40, Iss 0 (2019)
RESUMO: Desde os anos 1990 há aproximação entre universidades e sociedade. Nesse contexto, buscou-se entender como essa aproximação se manifesta em convênios. Realizou-se levantamento de dados primários dos convênios da Universidade Estadual
Externí odkaz:
https://doaj.org/article/c21247fcf5954202b2c1d2f507f6cde5
Autor:
Naomi Sakashita, Catherine C.Y. Chang, Xiaofeng Lei, Yukio Fujiwara, Motohiro Takeya, Ta-Yuan Chang
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 6, Pp 1263-1272 (2010)
ACAT1 is normally a resident enzyme in the endoplasmic reticulum (ER). We previously showed that treating macrophages with denatured LDL causes a large increase in ER-derived, ACAT1-positive vesicles. Here, we isolated ER membranes and ER-derived ves
Externí odkaz:
https://doaj.org/article/e10b0ec9aa2749b4abfb74e334cd01d6
Autor:
Patrick C. Reid, Naomi Sakashita, Shigeki Sugii, Yoshiko Ohno-Iwashita, Yukiko Shimada, William F. Hickey, Ta-Yuan Chang
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 3, Pp 582-591 (2004)
Niemann-Pick type C (NPC) is a neurodegenerative disorder characterized by progressive accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and visceral organs. In the NPC1 mouse model, neurodegeneration and neuro
Externí odkaz:
https://doaj.org/article/bea23713b1544e268d826f433828d7b1
Autor:
Akira Shigenaga, Hiroyuki Saito, Naomi Sakashita, Shiho Mikawa, Teruhiko Baba, Kazuchika Nishitsuji, Akira Otaka, Kenichi Akaji, Chiharu Mizuguchi, Toshinori Shimanouchi
Publikováno v:
FEBS Letters. 590:3492-3500
Glycosaminoglycans are known to be associated with extracellular amyloid deposits of various amyloidogenic proteins. In this study, we found that the glycosaminoglycan heparin greatly accelerates the elongation step in fibril formation by the N-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb7368d64b9bec124af78039d1e73e6
https://doi.org/10.1002/1873-3468.12426
https://doi.org/10.1002/1873-3468.12426
Autor:
Naomi Sakashita, Hiroyuki Saito, Yuki Takechi-Haraya, Kohsaku Kawakami, Hitoshi Kimura, Ryo Nadai, Toru Kawakami, Kazuchika Nishitsuji, Hironobu Hojo, Kumiko Sakai-Kato, Akira Shigenaga, Kenji Uchimura, Akira Otaka
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:1339-1349
The first step of cell membrane penetration of arginine peptides is thought to occur via electrostatic interactions between positive charges of arginine residues and negative charges of sulfated glycosaminoglycans (GAGs) on the cell surface. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd63bfb454af1dd37990621549aa8a03
https://doi.org/10.1016/j.bbamem.2016.03.021
https://doi.org/10.1016/j.bbamem.2016.03.021
Autor:
Norihiro Kobayashi, Kaori Kuwabara, Yoshiki Kashiwada, Hiroyuki Nakajima, Hiroyuki Saito, Shiho Mikawa, Kazuchika Nishitsuji, Kenji Uchimura, Naomi Sakashita, Hiroyuki Kawashima, Kenichi Akaji
Publikováno v:
Amyloid. 23:17-25
Apolipoprotein A-I (apoA-I) amyloidosis is either a non-hereditary form with deposits of wild-type apoA-I proteins in atherosclerotic plaques or a hereditary form with progressive accumulation of mutant apoA-I proteins in different tissues. Several s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c46fe7257cc606c297bd7268acc410
https://doi.org/10.3109/13506129.2015.1113167
https://doi.org/10.3109/13506129.2015.1113167
Autor:
Shiho Mikawa, Shang-Cheng Hung, Kenji Uchimura, Hiroyuki Nakajima, Naomi Sakashita, Norihiro Kobayashi, Hiroyuki Saito, Kaori Kuwabara, Kazuchika Nishitsuji, Makoto Mizuguchi
Publikováno v:
Journal of Biological Chemistry. 290:24210-24221
The single amino acid mutation G26R in human apolipoprotein A-I (apoA-I) is associated with familial amyloid polyneuropathy III. ApoA-I carrying this mutation (apoA-IIowa) forms amyloid fibrils in vitro. Heparan sulfate (HS) is a glycosaminoglycan th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5368b958ef6c19d872f9ee0822ee9912
https://doi.org/10.1074/jbc.m115.652545
https://doi.org/10.1074/jbc.m115.652545
Autor:
Kazuchika Nishitsuji, Motohiro Takeya, Naomi Sakashita, Yuto Yanagisawa, Nobuyuki Yoshitani, Takuji Ohmoto, Tetsuji Takayama
Publikováno v:
Pathology International. 65:264-270
Carcinoma with rhabdoid features is a rare malignant tumor with a poor prognosis whose molecular mechanism for aggressive behavior is unclear. We describe an undifferentiated pancreatic carcinoma with rhabdoid features that demonstrated extensive inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f560709763e7e6a0ead9e6c712b2e9a6
https://doi.org/10.1111/pin.12283
https://doi.org/10.1111/pin.12283
Autor:
Kensuke Kawakami, N. Tawara, Satoshi Yamashita, Takenobu Nakagawa, Masayoshi Tasaki, Taro Yamashita, Naomi Sakashita, Teruyuki Hirano, Yoshihiro Komohara, Masashi Kamikawa, Yukio Fujiwara, Yasushi Maeda, Masato Hasegawa, Motohiro Takeya, Yukio Ando
Publikováno v:
Journal of Neurology. 261:2209-2217
Pathological changes in corticobasal degeneration (CBD) consist of abnormal deposition of the microtubule-associated protein tau. However, the simultaneous accumulation of different misfolded proteins in the brain can be observed in many neurodegener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f78b464ffe36d2bf01b2e7d33f90935
https://doi.org/10.1007/s00415-014-7491-8
https://doi.org/10.1007/s00415-014-7491-8
Autor:
Motohiro Takeya, Kazuchika Nishitsuji, Masashi Kamikawa, Naomi Sakashita, Hiroshi Mizuta, Xiao-Feng Lei, Yukio Fujiwara
Publikováno v:
Acta Histochemica et Cytochemica
We previously demonstrated that macrophages exhibit endoplasmic reticulum fragmentation under cholesterol-rich conditions, which results in the generation of acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1)-associated late endosomes/lysosomes (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3a1a6b0984beb2a689910089cebf09
http://europepmc.org/articles/PMC4105798
http://europepmc.org/articles/PMC4105798