Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Naomi, Guppy"'
Autor:
Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O. Haich, Gianmaria Liccardi, Sidonie Wicky John, Alessandro Annibaldi, Lu Yu, Mercedes Pardo, Samuel N. Young, Cheree Fitzgibbon, Winnie Fernando, Naomi Guppy, Hyojin Kim, Lung-Yu Liang, Isabelle S. Lucet, Andrew Kueh, Ioannis Roxanis, Patrycja Gazinska, Martin Sims, Tomoko Smyth, George Ward, John Bertin, Allison M. Beal, Brad Geddes, Jyoti S. Choudhary, James M. Murphy, K. Aurelia Ball, Jason W. Upton, Pascal Meier
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Necroptosis is a form of cell death characterized by membrane rupture via MLKL oligomerization, although mechanistic details remain unclear. Here, the authors show that MLKL ubiquitylation of K219 facilitates high-order membrane assembly and subseque
Externí odkaz:
https://doaj.org/article/028b10c801d94af293be6d1707508113
Autor:
Priya Lakshmi Narayanan, Shan E. Ahmed Raza, Allison H. Hall, Jeffrey R. Marks, Lorraine King, Robert B. West, Lucia Hernandez, Naomi Guppy, Mitch Dowsett, Barry Gusterson, Carlo Maley, E. Shelley Hwang, Yinyin Yuan
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Despite increasing evidence supporting the clinical relevance of tumour infiltrating lymphocytes (TILs) in invasive breast cancer, TIL spatial variability within ductal carcinoma in situ (DCIS) samples and its association with progression ar
Externí odkaz:
https://doaj.org/article/933aafb5df734dabbcabf44349806765
Autor:
Henry G Smith, Kunzah Jamal, Jasbani HS Dayal, Tencho Tenev, Joan Kyula‐Currie, Naomi Guppy, Patrycja Gazinska, Victoria Roulstone, Gianmaria Liccardi, Emma Davies, Ioannis Roxanis, Alan A Melcher, Andrew J Hayes, Gareth J Inman, Kevin J Harrington, Pascal Meier
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-17 (2020)
Abstract Drugs that mobilise the immune system against cancer are dramatically improving care for many people. Dying cancer cells play an active role in inducing anti‐tumour immunity but not every form of death can elicit an immune response. Moreov
Externí odkaz:
https://doaj.org/article/ebe09b78de1144a5ac46382d903dbfad
Autor:
Siu Man Tsang, Hyojin Kim, Erik Oliemuller, Richard Newman, Naa-Anyima Boateng, Naomi Guppy, Beatrice A. Howard
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 5 (2021)
Little is known about the role of Sox11 in the regulation of mammary progenitor cells. Sox11 is expressed by mammary bud epithelial cells during embryonic mammary gland development and is not detected in mammary epithelial cells after birth. As Sox11
Externí odkaz:
https://doaj.org/article/f2bc5b0108d0414ea87f2f845ed7b06e
Autor:
Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Publikováno v:
Cancer Research. 83:P6-10
Background: Heterozygous hotspot mutations in the RNA splicing factor SF3B1, occur in 3% of unselected breast cancers and are associated with oestrogen receptor (ER+) breast cancer (BC) where they are enriched in metastatic disease and are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dd549b1ea099cf9881e0df9401b989
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-05
https://doi.org/10.1158/1538-7445.sabcs22-p6-10-05
Publikováno v:
Open Veterinary Journal, Vol 7, Iss 4, Pp 300-305 (2017)
The Amur tiger (Panthera tigris altaica) is an endangered tiger subspecies. An adult zoo-bred female was found collapsed, and died despite supportive treatment. Hematology and biochemistry showed pancytopenia and hyperglobulinemia, and serum protein
Externí odkaz:
https://doaj.org/article/7e0e15936d1c45b7adb79aad388e5111
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Western blots quantification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d6be537882550eb523bf94f524030e
https://doi.org/10.1158/1535-7163.22521774.v1
https://doi.org/10.1158/1535-7163.22521774.v1
Autor:
Dean A. Fennell, Andrew M. Fry, Paul Baas, Sam M. Janes, Aaron S. Mansfield, Michael Sheaff, Apostolos Nakas, Naomi Guppy, Laurel M. Schunselaar, Neelam Kumar, Aimee Parsons, Joanna Dzialo, Alan G. Dawson, Annabel J. Sharkey, Anita Singh, Laura O'Regan, Sara Busacca
Prognostic effect of MAD2L1 in second line cohort. Kaplan Meier curve for overall survival (OS) in patients treated with vinorelbine second line (n=3) stratified according to MAD2L1 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312bc1eec825c4153b74e0be8390484d
https://doi.org/10.1158/1535-7163.22521783.v1
https://doi.org/10.1158/1535-7163.22521783.v1
Autor:
Rachael Natrajan, Andrew N. Tutt, Syed Haider, Jyoti S. Choudhary, Fredrik Wallberg, Frances Daley, Paul Huang, Lukas Krasny, Simon McDade, Gerard Quinn, Sophie Postel-Vinay, Farzana Noor, Maggie C.U. Cheang, Erle M. Holgersen, Lesley-Ann Martin, Sunil Pancholi, Ioannis Roxanis, Patrycja Gazinska, Kalnisha Naidoo, Natasa Medic Milijic, Snezana Susnjar, Daniela Kolarevic, Naomi Guppy, Eleanor Knight, Daniela Novo, Rebecca Marlow, Richard Buus, Gillian Farnie, Keith Brennan, Giulia Falgari, Amy Gibson, Lu Yu, Divya Kriplani, Eamonn Morrison, Holly E. Barker, Sarah L. Maguire, Patty T. Wai, Hannah Cottom, Gareth Muirhead, Ioanna Mavrommati, Philip Bland, Barrie Peck
Triple-negative breast cancers (TNBC) are resistant to standard-of-care chemotherapy and lack known targetable driver gene alterations. Identification of novel drivers could aid the discovery of new treatment strategies for this hard-to-treat patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f47c62b476b5b1eb748b5362d5aeca
https://doi.org/10.1158/0008-5472.c.6512466.v1
https://doi.org/10.1158/0008-5472.c.6512466.v1
Autor:
Rachael Natrajan, Andrew N. Tutt, Syed Haider, Jyoti S. Choudhary, Fredrik Wallberg, Frances Daley, Paul Huang, Lukas Krasny, Simon McDade, Gerard Quinn, Sophie Postel-Vinay, Farzana Noor, Maggie C.U. Cheang, Erle M. Holgersen, Lesley-Ann Martin, Sunil Pancholi, Ioannis Roxanis, Patrycja Gazinska, Kalnisha Naidoo, Natasa Medic Milijic, Snezana Susnjar, Daniela Kolarevic, Naomi Guppy, Eleanor Knight, Daniela Novo, Rebecca Marlow, Richard Buus, Gillian Farnie, Keith Brennan, Giulia Falgari, Amy Gibson, Lu Yu, Divya Kriplani, Eamonn Morrison, Holly E. Barker, Sarah L. Maguire, Patty T. Wai, Hannah Cottom, Gareth Muirhead, Ioanna Mavrommati, Philip Bland, Barrie Peck
Enrichment analysis from TCGA RNA-seq and RPPA data comparing CREBBPaltered versus wild-type patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273510b1dd0d539ca6c9b1f08a4eff95
https://doi.org/10.1158/0008-5472.22426827
https://doi.org/10.1158/0008-5472.22426827