Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Naoko Ohtani-Fujita"'
Autor:
Wei-hui Guo, Y Ishidou, Masahiro Kawabata, Naoko Ohtani-Fujita, Minoru Fukuchi, Janet Stavnezer, Lin Feng Chen, Yoshiaki Ito, Meng Jiao Shi, Takeshi Imamura, Kohei Miyazono, Tomohiko Kanno, Jun-ichi Hanai, Woo-Young Kim
Publikováno v:
Journal of Biological Chemistry. 274:31577-31582
Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand stimulation, receptor-regulated Smads (R-Smads) are phosphorylated by serine/threonine kinase receptors, form complexes with common-pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ab42b23614a800cc67e2cb3367a6a1
https://doi.org/10.1074/jbc.274.44.31577
https://doi.org/10.1074/jbc.274.44.31577
Autor:
Gerald A. Rosenthal, Naoko Ohtani-Fujita, Yi Ding, Yoshizumi Matsukawa, Toshiyuki Sakai, Takaaki Fujii, Daishiro Kato, Yuji Naito, Su Dao, Toshikazu Yoshikawa
Publikováno v:
Japanese Journal of Cancer Research : Gann
L-Canavanine (CAV) is a higher plant nonprotein amino acid and a potent L-arginine antimetabolite. CAV can inhibit the proliferation of tumor cells in vitro and in vivo, but little is known regarding the molecular mechanisms mediating these effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4e2c43a37e4c711cdd53ddeed6c081e
http://europepmc.org/articles/PMC5925972
http://europepmc.org/articles/PMC5925972
Autor:
Takayoshi Matsui, Toshiyuki Sakai, Yi Ding, Fulu Bai, Naoko Ohtani-Fujita, Yoshizumi Matsukawa
Publikováno v:
FEBS Letters. 437:61-64
Flavonoids are present in many plants including edible fruits and vegetables. Recently, many of the biological activities of flavonoids have been elucidated. Flavone is a well known flavonoid, and many of its derivatives have been shown to have anti-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ff6055dafc29ebf9aab9dff4471405
https://doi.org/10.1016/s0014-5793(98)01198-3
https://doi.org/10.1016/s0014-5793(98)01198-3
Publikováno v:
Biochemical and Biophysical Research Communications. 251:648-652
A p53-inducible gene, the growth arrest and DNA damage-inducible gene 45 (gadd45), is associated with cell growth inhibition, DNA damage response and DNA repair. Here we report that Delta12-prostaglandin J2 (Delta12-PGJ2), an in vivo metabolite of ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5875e2465a87c168b901e55d34467ed
https://doi.org/10.1006/bbrc.1998.9511
https://doi.org/10.1006/bbrc.1998.9511
Autor:
Toshio Nikaido, Fulu Bai, Tetsuya Tamaki, Toshiyuki Sakai, Yoshihiro Sowa, Takuji Matsumoto, Naoko Ohtani-Fujita
Publikováno v:
Japanese Journal of Cancer Research : Gann
A universal inhibitor of cyclin‐dependent kinases, WAF1/Cip1 can dephosphorylate the RB gene product to arrest the cell cycle at the G1 phase. Here we show that the mRNA level and the promoter activities of the RB and WAF1/Cip1 genes exhibit cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cae9b9a165b9181c774559c17d3f714
https://doi.org/10.1111/j.1349-7006.1998.tb03264.x
https://doi.org/10.1111/j.1349-7006.1998.tb03264.x
Autor:
Joyce M. Rapaport, Takafumi Matsumura, Shigeru Kinoshita, Masao S. Sasaki, Tsuyoshi Fujita, Kanji Ishizaki, Bernhard Horsthemke, Toshiyuki Sakai, Kyohei Hayashi, Kensei Minoda, Rei Takahashi, Naoko Ohtani-Fujita, Mitsuo Kato, Yoshitaka Ohnishi, Satoshi Matsumura, Yoshiyuki Watanabe, Thaddeus P. Dryja, Kotaro Ozasa, Koshi Maeda, Yoshihiro Hotta
Publikováno v:
Cancer Genetics and Cytogenetics. 98:43-49
We previously reported 9 unilateral, sporadic retinoblastomas with hypermethylation in the 5' region of the RB gene, and we found that CpG methylation in the RB promoter inhibits the binding of the retinoblastoma binding factor 1 (RBF-1) and the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26cc40f089d030908a1af15d71f9e058
https://doi.org/10.1016/s0165-4608(96)00395-0
https://doi.org/10.1016/s0165-4608(96)00395-0
Autor:
Hisakazu Yamagishi, Yoshizumi Matsukawa, Takashi Tokino, Takahiro Oka, Yusuke Okuyama, Takakazu Mizuno, Yoshihiro Sowa, Tsuyoshi Fujita, Naoko Ohtani-Fujita, Katsunori Nakano, Toshiyuki Sakai, Hitoshi Nomura, Takeshi Yoshino, Tetsuro Orita
Publikováno v:
Journal of Biological Chemistry. 272:22199-22206
Butyrate is a well known colonic luminal short chain fatty acid, which arrests cell growth and induces differentiation in various cell types. We examined the effect of butyrate on the expression of WAF1/Cip1, a potent inhibitor of cyclin-dependent ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c023837b6ee99f222d19e7be252e2c
https://doi.org/10.1074/jbc.272.35.22199
https://doi.org/10.1074/jbc.272.35.22199
Publikováno v:
FEBS Letters. 411:1-6
p27Kip1 is an inhibitor of multiple cyclin-dependent kinases (cdk), and can arrest the cell-cycle progression by inhibiting the phosphorylation of the retinoblastoma gene family products. Tumor formation in p27Kip1 knockout mice clearly shows that p2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca32e1e7b9a6508ec137e95b22eb7cff
https://doi.org/10.1016/s0014-5793(97)00660-1
https://doi.org/10.1016/s0014-5793(97)00660-1
Autor:
Seong-Jin Kim, Di Jiang, Nicole E. Osifchin, Toshiyuki Sakai, Michael Carroza, Tsuyoshi Fujita, Naoko Ohtani-Fujita, Paul D. Robbins
Publikováno v:
Journal of Biological Chemistry. 269:6383-6389
p53 is a tumor suppressor gene found to be mutated in a wide variety of tumors. The encoded p53 protein has properties of a classical transcription factor, but the promoter targets for its regulation are largely unknown. We have investigated the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b3b4ae775688296e3166047f800e0f
https://doi.org/10.1016/s0021-9258(17)37383-0
https://doi.org/10.1016/s0021-9258(17)37383-0
Autor:
Eiji Igata, Yoshihiro Sowa, Yoshihide Tsujimoto, Toshiyuki Sakai, Toshiaki Inoue, Naoko Ohtani-Fujita
Publikováno v:
Gene. 238(2)
Bcl-2-associated X protein (Bax) is a proapoptotic protein and is suggested to have an important role in carcinogenesis. To investigate the mechanism of bax gene transcriptional regulation, we isolated and sequenced the genomic DNA fragment of the 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67efc4a939ff5772f4cdf5f807c6b294
https://pubmed.ncbi.nlm.nih.gov/10570968
https://pubmed.ncbi.nlm.nih.gov/10570968