Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Naoko Nakano"'
Autor:
Anne Trefzer, Pallavi Kadam, Shu-Hung Wang, Stefanie Pennavaria, Benedikt Lober, Batuhan Akçabozan, Jan Kranich, Thomas Brocker, Naoko Nakano, Martin Irmler, Johannes Beckers, Tobias Straub, Reinhard Obst
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108748- (2021)
Summary: Exhausted immune responses to chronic diseases represent a major challenge to global health. We study CD4+ T cells in a mouse model with regulatable antigen presentation. When the cells are driven through the effector phase and are then expo
Externí odkaz:
https://doaj.org/article/591264a4d4324b9a8794cbb7e208457b
Autor:
Rie Kawamoto, Naoko Nakano, Haruka Ishikawa, Etsu Tashiro, Waka Nagano, Keigo Sano, Miki Irie, Mariko Ikuta, Fukuko Kishi, Takahisa Nakane, Mikihiko Naito, Susumu Itoh
Publikováno v:
BBA Advances, Vol 1, Iss , Pp 100008- (2021)
Yes-associated protein (YAP) is involved in development, cell growth, cell size, and homeostasis and plays a key role in the progression of various cancers. Among them, constitutive activation of YAP can often be observed in malignant mesothelioma, w
Externí odkaz:
https://doaj.org/article/b631388b21c244839b8427702452f753
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237646 (2020)
Tumor antigen-primed CD8 T cells differentiate into effector T cells that kill tumor cells rapidly, whereas durable responses of CD8 T cells are required to cope with long-lasting tumor growth. However, it is not well known how persisting CD8 T cells
Externí odkaz:
https://doaj.org/article/e0444b59d4a3423b89bd7eed4811fbab
Autor:
Naoe Kaneko, Tomoyuki Iwasaki, Yuki Ito, Hiroyuki Takeda, Tatsuya Sawasaki, Shinnosuke Morikawa, Naoko Nakano, Mie Kurata, Junya Masumoto
Publikováno v:
Inflammation and Regeneration, Vol 37, Iss 1, Pp 1-7 (2017)
Abstract The inflammasome, typically consisting of a Nod-like receptor, apoptosis-associated speck-like protein, and pro-caspase-1, has recently been identified as a huge intracellular complex, which plays a crucial role in interleukin-1 maturation o
Externí odkaz:
https://doaj.org/article/4d10b2e62750477bbf886a534fde92db
Autor:
Yoshihito Nakagawa, Yukihiro Akao, Kohei Taniguchi, Akemi Kamatani, Tomomitsu Tahara, Toshiaki Kamano, Naoko Nakano, Naruomi Komura, Hirokazu Ikuno, Takafumi Ohmori, Yasutaka Jodai, Masahiro Miyata, Mistuo Nagasaka, Tomoyuki Shibata, Naoki Ohmiya, Ichiro Hirata
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 1526-1543 (2015)
Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We examined the expression of onco-related miRNAs
Externí odkaz:
https://doaj.org/article/b06e0e7e577c4b619abf2c60aa02fe8a
Autor:
Akihiko Miyatake, Mari Fujita, Yukio Nagasaka, Kimie Fujita, Mayumi Tamari, Dai Watanabe, Naoko Nakano, Kazuya I.P.J. Hidari, Yasuo Suzuki
Publikováno v:
Allergology International, Vol 56, Iss 3, Pp 231-239 (2007)
Background: Viral infection of the respiratory tract in patients with asthma is one of the most frequent causes of exacerbation of asthmatic symptoms. Disodium cromoglycate (DSCG) is a commonly used anti-asthmatic medicine with many beneficial bioche
Externí odkaz:
https://doaj.org/article/f6bed234a45342f2808bcee2e7da0d7b
Publikováno v:
The Journal of Immunology. 210:1482-1493
Thymocytes having diverse Ag specificities are selected in response to self-MHC–peptide expressed in thymic epithelial cells, which contributes to the formation of a T cell repertoire. However, it is not well understood whether additional signals f
Autor:
Naoko Nakano, Kazuo Fukuda, Etsu Tashiro, Haruka Ishikawa, Waka Nagano, Rie Kawamoto, Alice Mori, Misao Watanabe, Ryu Yamazaki, Takahisa Nakane, Mikihiko Naito, Iwao Okamoto, Susumu Itoh
Publikováno v:
The Journal of Biochemistry. 171:631-640
Dysregulated yes-associated protein (YAP) is involved in several malignant cancers. However, discovering a druggable YAP inhibitor(s) is difficult because YAP itself does not have any enzymatic activity. In such cases, targeted protein degradation st
Autor:
Takahiro Yasumi, Ryuta Nishikomori, Osamu Ohara, Yusuke Kawashima, Tomohiro Morio, Kosaku Murakami, Syuji Takei, Tomohiro Kubota, Toshio Heike, Makio Takahashi, Hirokazu Kanegane, Hidetoshi Takada, Masahiko Isa-Nishitani, Atsushi Hijikata, Moeko Ito, Takeshi Shiba, Shunsuke Kajikawa, Tadateru Yasu, Naoko Nakano, Shouichi Ohga, Tsubasa Okano, Hiroaki Umebayashi, Junko Takita, Yoshinori Hasegawa, Dai Keino, Sachiko Iwaki-Egawa, Etsuro Nanishi, Hiroshi Nihira, Kazushi Izawa, Yoji Sasahara, Yoshitaka Honda
Publikováno v:
Journal of Allergy and Clinical Immunology. 148:550-562
Background Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive inflammatory disease caused by loss-of-function mutations in both alleles of the ADA2 gene. Most patients with DADA2 exhibit systemic vasculopathy consistent with polyar
Autor:
Hidehiko Narazaki, Shinji Akioka, Yuko Akutsu, Mariko Araki, Mikiya Fujieda, Daisuke Fukuhara, Ryoki Hara, Kunio Hashimoto, Seira Hattori, Ren Hayashibe, Tomoyuki Imagawa, Yuzaburo Inoue, Hiroyuki Ishida, Shuici Ito, Yasuhiko Itoh, Tomohiro Kawabe, Toshiyuki Kitoh, Ichiro Kobayashi, Tadashi Matsubayashi, Takako Miyamae, Mao Mizuta, Masaaki Mori, Ayako Murase, Yasuo Nakagishi, Koji Nagatani, Naoko Nakano, Toyoki Nishimura, Tomo Nozawa, Nami Okamoto, Yuka Okura, Hiromi Sawada, Emi Sawanobori, Yuko Sugita, Yujiro Tanabe, Minako Tomiita, Ken-ichi Yamaguchi, Ryuhei Yasuoka, Koji Yokoyama
Publikováno v:
Modern Rheumatology.
Objectives Although epidemiological surveys of paediatric rheumatic diseases in Japan have been conducted, they were single surveys with no continuity. This is the first report of the Pediatric Rheumatology Association of Japan registry database, whi