Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Naoko Koyano-Nakagawa"'
Autor:
Naoko Koyano-Nakagawa, Wuming Gong, Satyabrata Das, Joshua W. M. Theisen, Tran B. Swanholm, Daniel Van Ly, Nikita Dsouza, Bhairab N. Singh, Hiroko Kawakami, Samantha Young, Katherine Q. Chen, Yasuhiko Kawakami, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The embryonic limb bud is known to be patterned by a Shh morphogen gradient, though how Shh expression is activated remains less clear. Here the authors show that Etv2 acts as a pioneer transcription factor to mediate accessibility of the ZRS enhance
Externí odkaz:
https://doaj.org/article/78037045b7d940fa8cf10e68eb7f55dd
Autor:
Bhairab N. Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P. Moskowitz, Cyprian V. Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H. van Berlo, Mary G. Garry, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation an
Externí odkaz:
https://doaj.org/article/e834b139d7d24de2a7e908969edba69b
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Time series single cell expression data has large variance between time points and is challenging for analysis. Here, the authors develop a new dimension reduction and data visualization tool for large scale temporal scRNA-seq data which identifies t
Externí odkaz:
https://doaj.org/article/3107b11735c5411d8a8c981b9ffc4189
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background The single cell RNA sequencing (scRNA-seq) technique begin a new era by allowing the observation of gene expression at the single cell level. However, there is also a large amount of technical and biological noise. Because of the
Externí odkaz:
https://doaj.org/article/eab0087e6a5748c9becf89601d4f5ace
Autor:
Wuming Gong, Tara L. Rasmussen, Bhairab N. Singh, Naoko Koyano-Nakagawa, Wei Pan, Daniel J. Garry
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Single-cell RNA sequencing has enabled great advances in understanding developmental biology but reconstructing cellular lineages from this data remains challenging. Here the authors develop an algorithm,dpath, which models the lineage relationships
Externí odkaz:
https://doaj.org/article/26a6e5fde8f54559bc2ee0105ac8cd5d
Autor:
June Baik, Alessandro Magli, Naoyuki Tahara, Scott A. Swanson, Naoko Koyano-Nakagawa, Luciene Borges, Ron Stewart, Daniel J. Garry, Yasuhiko Kawakami, James A. Thomson, Rita C. R. Perlingeiro
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haem
Externí odkaz:
https://doaj.org/article/2ffd9d9f384f4d06b3c823151dd71c1e
Autor:
Bhairab N. Singh, Yasuhiko Kawakami, Ryutaro Akiyama, Tara L. Rasmussen, Mary G. Garry, Wuming Gong, Satyabrata Das, Xiaozhong Shi, Naoko Koyano-Nakagawa, Daniel J. Garry
Publikováno v:
Cell Reports, Vol 13, Iss 5, Pp 915-923 (2015)
MicroRNAs (miRNAs) are known to regulate critical developmental stages during embryogenesis. Here, we defined an Etv2-miR-130a cascade that regulates mesodermal specification and determination. Ablation of Dicer in the Etv2-expressing precursors resu
Externí odkaz:
https://doaj.org/article/bfe896d61df64337aabf7195e993141c
Autor:
Bhairab N Singh, Naoyuki Tahara, Yasuhiko Kawakami, Satyabrata Das, Naoko Koyano-Nakagawa, Wuming Gong, Mary G Garry, Daniel J Garry
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189010 (2017)
Remodeling of the primitive vasculature is necessary for the formation of a complex branched vascular architecture. However, the factors that modulate these processes are incompletely defined. Previously, we defined the role of microRNAs (miRNAs) in
Externí odkaz:
https://doaj.org/article/5f952302b3da4393b3be6148dfa367d4
Autor:
Tara L Rasmussen, Xiaozhong Shi, Alicia Wallis, Junghun Kweon, Katie M Zirbes, Naoko Koyano-Nakagawa, Daniel J Garry
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50103 (2012)
Previous reports regarding the genetic hierarchy between Ets related protein 71 (Er71/Etv2) and Flk1 is unclear. In the present study, we pursued a genetic approach to define the molecular cascade between Etv2 and Flk1. Using a transgenic Etv2-EYFP r
Externí odkaz:
https://doaj.org/article/56d3b41387704585a221bc05db56cdd2
Autor:
Stefan M. Kren, Mary G. Garry, Jacob H. Hanna, Kyung-Dal Choi, Bhairab N. Singh, Demetri Yannopoulos, Cyprian Weaver, Tara L. Rasmussen, Satyabrata Das, Xiaoyan Pan, Daniel J. Garry, Pruthvi Pota, Naoko Koyano-Nakagawa, Ohad Gafni, Wuming Gong, Geunho Maeng, Daniel J. Mickelson
Publikováno v:
Nature Biotechnology. 38:297-302
The scarcity of donor organs may be addressed in the future by using pigs to grow humanized organs with lower potential for immunological rejection after transplantation in humans. Previous studies have demonstrated that interspecies complementation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b112f7da9b42c9bcf0d730013939299
https://doi.org/10.1038/s41587-019-0373-y
https://doi.org/10.1038/s41587-019-0373-y