Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Naoko Kamimura"'
Autor:
Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki, Yohei Watanabe
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105742- (2023)
Summary: Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines. Despite this, the interferon (IFN) response is delayed, contributing to disease progression. Here, we report that SARS-CoV-2 excess
Externí odkaz:
https://doaj.org/article/202864d4bcda480e82fad3dd93516c0b
Autor:
Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tatsuya Suzuki, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki, Yohei Watanabe
Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines during worsening disease. Despite this, the interferon (IFN) response is delayed, contributing to disease progression. Here, we report that S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2b144986b90014349c11d8aaffdd19c
https://doi.org/10.21203/rs.3.rs-1271053/v2
https://doi.org/10.21203/rs.3.rs-1271053/v2
Autor:
Yohei Watanabe, Yasuha Arai, Itaru Yamanaka, Toru Okamoto, Ayana Isobe, Naomi Nakai, Naoko Kamimura, Tomo Daidoji, Takao Ono, Takaaki Nakaya, Kazuhiko Matsumoto, Daisuke Okuzaki
Patients with severe COVID-19 exhibit a cytokine storm characterized by greatly elevated levels of cytokines during worsening disease1-4. Despite this, the interferon (IFN) response is delayed, contributing to disease progression5. Here, we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a887f5ccaee73acff91a3eda9b9f92e6
https://doi.org/10.21203/rs.3.rs-1271053/v1
https://doi.org/10.21203/rs.3.rs-1271053/v1
Autor:
Shuichi Tsutsumi, Daizo Koinuma, Hiroshi Suzuki, Naoko Kamimura, Hiroyuki Aburatani, Anna Mizutani, Masato Morikawa, Kohei Miyazono, Takeshi Imamura
Publikováno v:
The Journal of Biological Chemistry
Specific regulation of target genes by transforming growth factor-β (TGF-β) in a given cellular context is determined in part by transcription factors and cofactors that interact with the Smad complex. In this study, we determined Smad2 and Smad3 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1245db345e783c8ed6749210ded90d4d
https://doi.org/10.1074/jbc.m110.217745
https://doi.org/10.1074/jbc.m110.217745
Autor:
Naoko Kamimura, Daizo Koinuma, Shuichi Tsutsumi, Hiroyuki Aburatani, Takeshi Imamura, Kohei Miyazono
Publikováno v:
Cancer Science. 100:2133-2142
Smad4, the common partner Smad, is a key molecule in transforming growth factor-β (TGF-β) family signaling. Loss of Smad4 expression is found in several types of cancer, including pancreatic cancer and colon cancer, and is related to carcinogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6f029c1c2382122ea61e83d2be4602
https://doi.org/10.1111/j.1349-7006.2009.01299.x
https://doi.org/10.1111/j.1349-7006.2009.01299.x
Autor:
Fumio Tashiro, Shuichi Tsutsumi, Naoko Kamimura, Tatsuhiro Shibata, Tsutomu Ohta, Yoichi Taya, Hiroyuki Aburatani, Tatsuya Kawase, Hitoshi Ichikawa, Johji Inazawa, Rieko Ohki
Publikováno v:
Cell. 136:535-550
Summaryp53 and Akt are critical players regulating tumorigenesis with opposite effects: whereas p53 transactivates target genes to exert its function as a tumor suppressor, Akt phosphorylates its substrates and transduces downstream survival signals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9209879fdc439e3ca3b72c9ab5dd47f8
https://doi.org/10.1016/j.cell.2008.12.002
https://doi.org/10.1016/j.cell.2008.12.002
Autor:
Naoko Kamimura, Haruhiko Sugimura, Hisaki Igarashi, Shumpei Ishikawa, Hiroyuki Aburatani, Yutaka Midorikawa, Masatoshi Makuuchi, Shogo Yamamoto
Publikováno v:
Oncogene. 25:5581-5590
Genomic amplification of oncogenes and inactivation of suppressor genes are critical in the pathogenesis of human cancer. To identify chromosomal alterations associated with hepatocarcinogenesis, we performed allelic gene dosage analysis on 36 hepato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab0c31185ea78b113a19d77e3300be4
https://doi.org/10.1038/sj.onc.1209537
https://doi.org/10.1038/sj.onc.1209537
Autor:
Naoko Kamimura, Shuichi Tsutsumi, Hiroyuki Aburatani, Makoto Kano, Masatoshi Makuuchi, Yutaka Midorikawa, Hirohiko Sakamoto, Kunihiro Nishimura
Publikováno v:
Cancer Research. 64:7263-7270
To identify the chromosomal aberrations associated with the progression of liver cancer, we applied expression imbalance map analysis to gene expression data from 31 hepatocellular carcinomas and 19 noncancerous tissues. Expression imbalance map anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fffd1ff3f30451ec88198a6ff6a62cf
https://doi.org/10.1158/0008-5472.can-04-1275
https://doi.org/10.1158/0008-5472.can-04-1275
Autor:
Takashi Yoritaka, Shuichi Tsutsumi, Jihwan Myung, Sumio Sugano, Akinori Kanai, Toru Takumi, Naoko Kamimura, Yutaka Suzuki, Paolo Sassone-Corsi, Hiroyuki Aburatani, Fumiyuki Hatanaka, Chiaki Matsubara
Publikováno v:
Molecular and cellular biology. 30(24)
Circadian rhythms are common to most organisms and govern much of homeostasis and physiology. Since a significant fraction of the mammalian genome is controlled by the clock machinery, understanding the genome-wide signaling and epigenetic basis of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb01bba29aae8d8b1378aa5857eca2d
https://pubmed.ncbi.nlm.nih.gov/20937769
https://pubmed.ncbi.nlm.nih.gov/20937769
Autor:
Hisaki Igarashi, Masatoshi Makuuchi, Naoko Kamimura, Shingo Tsuji, Hiroyuki Aburatani, Shumpei Ishikawa, Yutaka Midorikawa, Shogo Yamamoto, Norihiro Kokudo, Haruhiko Sugimura
Publikováno v:
Hepatology (Baltimore, Md.). 49(2)
Early hepatocellular carcinoma (eHCC) originates from the hepatocytes of chronic liver disease and develops into classical hepatocellular carcinoma (HCC). To identify sequential genetic changes in multistep hepatocarcinogenesis, we analyzed molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c637ccd1400ac68e61154c0aa994b1
https://pubmed.ncbi.nlm.nih.gov/19105209
https://pubmed.ncbi.nlm.nih.gov/19105209