Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Naoko Kamano"'
Autor:
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Naoko Kamano, Naoto Watamura, Hiroki Sasaguri, Yuhei Takado, Yoshihiro Yoshihara, Takashi Saito, Takaomi C. Saido
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Accumulating evidence suggests that glutathione loss is closely associated with the progression of neurodegenerative disorders. Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC),
Externí odkaz:
https://doaj.org/article/0e2d8155c464445c84a3c0e68311ab35
Autor:
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
To understand the molecular processes that link Aβ amyloidosis, tauopathy and neurodegeneration, the authors screened for tau-interacting proteins. They demonstrated that a novel tau binding protein CAPON accelerates tau pathology and neuronal cell
Externí odkaz:
https://doaj.org/article/6d5539c0c38d49df96dcc5ad495fe5b8
Autor:
Shoko Hashimoto, Yukio Matsuba, Naoko Kamano, Naomi Mihira, Naruhiko Sahara, Jiro Takano, Shin-ichi Muramatsu, Takaomi C. Saido, Takashi Saito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/d4cdaa4019b54821b587298e23b64b1a
Autor:
Nobuhisa Iwata, Satoshi Tsubuki, Misaki Sekiguchi, Kaori Watanabe-Iwata, Yukio Matsuba, Naoko Kamano, Ryo Fujioka, Risa Takamura, Naoto Watamura, Naomasa Kakiya, Naomi Mihira, Takahiro Morito, Keiro Shirotani, Mann, David M. A., Robinson, Andrew C., Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, Makoto Higuchi, Saido, Takaomi C.
Publikováno v:
Life Science Alliance; Dec2024, Vol. 7 Issue 12, p1-17, 17p
Autor:
Hiroki Sasaguri, Takaomi C. Saido, Naoto Watamura, Naoko Kamano, Satoshi Tsubuki, Shoko Hashimoto, Per Nilsson, Takashi Saito, Naomasa Kakiya, Mika Takahashi
Publikováno v:
Molecular Psychiatry. 27:1816-1828
Alzheimer’s disease (AD) is characterized by the deposition of amyloid β peptide (Aβ) in the brain. The neuropeptide somatostatin (SST) regulates Aβ catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechani
Autor:
Naoto Watamura, Kaori Sato, Gen Shiihashi, Ayami Iwasaki, Naoko Kamano, Mika Takahashi, Misaki Sekiguchi, Naomi Mihira, Ryo Fujioka, Kenichi Nagata, Shoko Hashimoto, Takashi Saito, Toshio Ohshima, Takaomi C. Saido, Hiroki Sasaguri
Publikováno v:
Science Advances. 8
We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation ( App NL-G-F and App NL-F mice). We have now generated App knock-in mi
Autor:
Ayano Ishii, Yukio Matsuba, Naomi Mihira, Naoko Kamano, Takashi Saito, Shin-ichi Muramatsu, Makoto Yokosuka, Takaomi C Saido, Shoko Hashimoto
Publikováno v:
Journal of biochemistry. 172(4)
Amyloid-β and tau pathologies are important factors leading to neurodegeneration in Alzheimer’s disease (AD); however, the molecular mechanisms that link these pathologies remain unclear. Assuming that important though as yet unidentified factors
Autor:
Naoko Kamano, Takashi Saito, Gen Shiihashi, Naomi Yamazaki, Ayami Iwasaki, Mika Takahashi, Shoko Hashimoto, Ryo Fujioka, Toshio Ohshima, Kenichi Nagata, Misaki Sekiguchi, Takaomi C. Saido, Hiroki Sasaguri, Kaori Sato, Naoto Watamura
SUMMARYWe previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation (AppNL- G-F and AppNL-F mice). These models showed the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43e26f67c71a03140aaf1edbf7d18c0
https://doi.org/10.1101/2021.08.22.457278
https://doi.org/10.1101/2021.08.22.457278
Autor:
Naoto, Watamura, Naomasa, Kakiya, Per, Nilsson, Satoshi, Tsubuki, Naoko, Kamano, Mika, Takahashi, Shoko, Hashimoto, Hiroki, Sasaguri, Takashi, Saito, Takaomi C, Saido
Publikováno v:
Molecular psychiatry. 27(3)
Alzheimer's disease (AD) is characterized by the deposition of amyloid β peptide (Aβ) in the brain. The neuropeptide somatostatin (SST) regulates Aβ catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism
Autor:
Shoko Hashimoto, Naoko Kamano, Takashi Saito, Hiroki Sasaguri, Mika Takahashi, Per Nilsson, Naomasa Kakiya, Takaomi C. Saido, Naoto Watamura, Satoshi Tsubuki
The neuropeptide somatostatin (SST) regulates amyloid β peptide (Aβ) catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism by which SST regulates NEP activity remains unclear. Here we report the identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::000174c1b58875454862183323dd4092
https://doi.org/10.1101/2020.10.07.329318
https://doi.org/10.1101/2020.10.07.329318