Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Naoko Takane"'
Autor:
Hiroo Kaku, Shusuke Kohno, Ikuyo Miyake, Shingo Shoji, Yoichi Imamura, Kentaro Yamada, Tomoka Fukutani, Tokunori Mukai, Yuji Hiromatsu, Naoko Takane, Shuichi Otabe
Publikováno v:
Thyroid. 14:93-97
Graves' disease (GD) is an autoimmune disorder with genetic predisposition. Interferon-gamma (IFN-gamma) is an important mediator of inflammatory and immune responses. The aim of the present study was to investigate whether the polymorphism of IFN-ga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f78e4f90791f7cf60f405e68b69927b
https://doi.org/10.1089/105072504322880328
https://doi.org/10.1089/105072504322880328
Publikováno v:
Life Sciences. 59:1423-1429
The purpose of this study was to examine regulation of interleukin-1(IL-1)-induced tumor necrosis factor-alpha (TNF-alpha) production by a mouse beta-cell line (beta TC1). Three-hour incubation of beta TC1 cells with 5 U/ml of IL-1 beta results in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7f6c354a63d5c2103f56ffb08f7107
https://doi.org/10.1016/0024-3205(96)00470-5
https://doi.org/10.1016/0024-3205(96)00470-5
Publikováno v:
Life Sciences. 56:1467-1474
Nitric oxide (NO) has been implicated as an immunological effector molecule that mediates beta-cell dysfunction associated with Type 1 diabetes. To assess whether NO induces poly(ADP-ribose) synthesis in islet cells, we examined the effect of nitropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f02af4462446ec476b0ee2f263cece
https://doi.org/10.1016/0024-3205(95)00109-j
https://doi.org/10.1016/0024-3205(95)00109-j
Publikováno v:
Biochemical and Biophysical Research Communications. 197:22-27
It has been shown that nitric oxide (NO) is involved in islet cell damage induced by interleukin-1 (IL-1). Here we show that interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) synergistically induced NO production and inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933636e254ca0f18dc5d41a4020e5863
https://doi.org/10.1006/bbrc.1993.2435
https://doi.org/10.1006/bbrc.1993.2435
Publikováno v:
Biochemical and Biophysical Research Communications. 194:163-169
Interleukin-1 (IL-1) has been implicated as an effector in insulitis of Type 1 (insulin-dependent) diabetes. Exposure of a beta-cell line (beta TC1) to IL-1 beta resulted in an increase of preproinsulin mRNA at 0.5 h followed by a gradual decrease. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b802b55df8cf588b6610bc1b92b6d5f0
https://doi.org/10.1006/bbrc.1993.1799
https://doi.org/10.1006/bbrc.1993.1799
Publikováno v:
Acta Endocrinologica. 128:379-384
We investigated the effect of free radical scavengers on the actions of cytokines on islet cells. Interferon-gamma and tumor necrosis factor-alpha reduced the nicotinamide adenine dinucleotide content of mouse islet cells; the combination of interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b351bfa5295d76b87cde8ea692d795ec
https://doi.org/10.1530/acta.0.1280379
https://doi.org/10.1530/acta.0.1280379
Autor:
Hirohisa Kato, Atsuko Koga, Toyojiro Matsuishi, Naoko Takane, Rikako Iwanaga, Yoshihiro Sato, Yasutoshi Koga, Junko Tubone, Yukihiro Akita
Publikováno v:
Acta neuropathologica. 99(2)
Five unrelated patients harboring the A3243G mutation in the mitochondrial DNA (mtDNA) but presenting with different clinical phenotype were studied for their percentage of mutation at the single muscle fiber levels. One patient had a clinically and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdc73d086663b87e0a4bfb2f1503efe
https://pubmed.ncbi.nlm.nih.gov/10672326
https://pubmed.ncbi.nlm.nih.gov/10672326
Autor:
Tomoka Fukutani, Yuji Hiromatsu, Hiroo Kaku, Ikuyo Miyake, Tokunori Mukai, Yoichi Imamura, Shusuke Kohno, Naoko Takane, Shingo Shoji, Shuichi Otabe, Kentaro Yamada
Publikováno v:
Thyroid; 2/01/2004, Vol. 14 Issue 2, p93-97, 5p
Publikováno v:
Internal medicine (Tokyo, Japan). 32(8)
We determined whether, in 15 diabetic patients, a conventional low-protein diet containing a high proportion of mono- and disaccharides would lead to a deterioration of postprandial glucose metabolism. Three different test meals were given on 3 diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960be66707bdb471aca98ea7cad07775
https://pubmed.ncbi.nlm.nih.gov/8312660
https://pubmed.ncbi.nlm.nih.gov/8312660
Publikováno v:
Diabetes. 42(7)
Cytokines have been regarded as effector molecules responsible for beta-cell death and major histocompatibility complex hyperexpression in endocrine pancreas of type I diabetes. However, the mechanism that results in beta-cell-selective destruction h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1d037a0a76255778249ecae54d5e40
https://pubmed.ncbi.nlm.nih.gov/8099883
https://pubmed.ncbi.nlm.nih.gov/8099883