Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Naoki Toritsuka"'
Autor:
Yoshikazu Kuboi, Yuta Suzuki, Sotaro Motoi, Chiyuki Matsui, Naoki Toritsuka, Tomoya Nakatani, Kazuhiro Tahara, Yoshinori Takahashi, Yoko Ida, Ayaka Tomimatsu, Motohiro Soejima, Toshio Imai
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 339-351 (2023)
Complement component 5 (C5), an important molecule in the complement cascade, blockade by antibodies shows clinical efficacy in treating complement-mediated disorders. However, insufficient blockading induced by single-nucleotide polymorphisms in the
Externí odkaz:
https://doaj.org/article/559a07afa4574d66976dbd1708b7edec
Autor:
Tomomi Shibata, Takeshi Yamagata, Akihiro Kawade, Shoji Asakura, Naoki Toritsuka, Naoki Koyama, Atsushi Hakura
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-8 (2020)
Abstract Background Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO). Yet, there is a very limited number of studies evaluating acetone as a solvent
Externí odkaz:
https://doaj.org/article/eb96bf6f96e14d0fb6e95df8d078936f
Autor:
Naoki Koyama, Tomomi Shibata, Naoki Toritsuka, Takeshi Yamagata, Akihiro Kawade, Atsushi Hakura, Shoji Asakura
Publikováno v:
Genes and Environment
Genes and Environment, Vol 42, Iss 1, Pp 1-8 (2020)
Genes and Environment, Vol 42, Iss 1, Pp 1-8 (2020)
Background Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO). Yet, there is a very limited number of studies evaluating acetone as a solvent in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7a2c33056b9f58956fca13c26bc0a1
http://europepmc.org/articles/PMC6979378
http://europepmc.org/articles/PMC6979378
Autor:
Satoru Hosokawa, Atsushi Hakura, Osamu Tohyama, Kyoko Nakano-Ito, Naoki Koyama, Naoki Toritsuka, Yuki Seki, Shoji Asakura, Jiro Sonoda
Publikováno v:
Chemico-Biological Interactions. 240:164-170
Benzo[a]pyrene (BP) is highly mutagenic and yet does not lead to tumor development in the murine colon. We recently reported the generation of colonic tumors one week after treatment with BP followed by dextran sulfate sodium (DSS), a colitis-inducer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049b72eac5c43de695111c1af02d3ec5
https://doi.org/10.1016/j.cbi.2015.07.012
https://doi.org/10.1016/j.cbi.2015.07.012
Autor:
Tomochika Matsushita, Yoshinobu Igarashi, Hiroshi Yamada, Kayo Sumida, Tetsuro Urushidani, Naoki Toritsuka, Mikio Aoki, Kaori Abe-Tomizawa, Yasuo Ohno
Publikováno v:
Human & Experimental Toxicology. 30:1701-1709
Dimethyl sulfoxide (DMSO) is a very common organic solvent used for dissolving lipophilic substances, for example for in vitro cell-based assays. At the same time, DMSO is known to be cytotoxic at high concentrations. Therefore, it is important to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b0a317c9a4e087e3663d702ed97494
https://doi.org/10.1177/0960327111399325
https://doi.org/10.1177/0960327111399325
Autor:
Toshihiko Kasahara, Yumiko Mizukawa, Manabu Okuyama, Tetsuro Urushidani, Toshikazu Miyagishima, Kayoko Takashima, Katsumi Morishita, Taku Nagao, Naoki Toritsuka
Publikováno v:
Life Sciences. 78:2787-2796
The Toxicogenomics Project is a 5-year collaborative project by the Japanese government and pharmaceutical companies in 2002. Its aim is to construct a large-scale toxicology database of 150 compounds orally administered to rats. The test consists of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680316f0ac2d8e7f658683108caad671
https://doi.org/10.1016/j.lfs.2005.11.010
https://doi.org/10.1016/j.lfs.2005.11.010
Autor:
Tetsuro Urushidani, Naoki Toritsuka, Yumiko Mizukawa, Katsumi Morishita, Manabu Okuyama, Taku Nagao, Kayoko Takashima, Toshihiko Kasahara, Toshikazu Miyagishima
Publikováno v:
The Journal of Toxicological Sciences. 31:491-507
In order to verify the influence of the rat age on hepatotoxicity, male Sprague-Dawley rats of 6 (young) and 12 (adult) weeks of age were orally administered acetaminophen (APAP), isoniazid (INH), or carbon tetrachloride (CCl4). Liver samples were ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d622a7e469dff9e276e93bee3c6e687
https://doi.org/10.2131/jts.31.491
https://doi.org/10.2131/jts.31.491
Publikováno v:
The Journal of Toxicological Sciences. 24:45-53
Effects of ER-40133, an inhibitor of angiotensin converting enzyme (ACE), on weight gain and sodium and potassium balance were studied in growing SD male rats. Thirty-two animals (seven weeks of age) were divided into two groups; one received a stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1869ff6d38e8b0595737ab847e57e2
https://doi.org/10.2131/jts.24.45
https://doi.org/10.2131/jts.24.45
Autor:
Hirofumi Shoun, Sam-Yong Park, Udai P. Singh, Tetsutaro Iizuka, Yoshitsugu Shiro, Naoki Toritsuka
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1338:93-99
Two isozymes of nitric oxide reductase (Nor) from the denitrifying fungus Cylindrocarpon tonkinense (c.Nor1 and c.Nor2) are the heme-enzyme cytochrome P-450's (Usuda et al. (1995) Appl. Environ. Microbiol. 61, 883-889). However, they catalyze the NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc649eda3852614825213dbc459db989
https://doi.org/10.1016/s0167-4838(96)00193-8
https://doi.org/10.1016/s0167-4838(96)00193-8
Autor:
Alberto Morisetti, Fumio Sagami, Piero Tirone, Simona Bussi, Hirohiko Daimon, Shigeki Sawada, Naoki Toritsuka, Kevin Adams
Publikováno v:
The Journal of toxicological sciences. 24
The mutagenic potential of gadobenate dimeglumine formulation (E7155) was studied by the chromosome aberration test in cultured human lymphocytes. Human lymphocytes were exposed to E7155 at 0.078-10 mM both in the presence and absence of S9 mix deriv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a01465002a9e7793b50bc635d298dc
https://pubmed.ncbi.nlm.nih.gov/10637784
https://pubmed.ncbi.nlm.nih.gov/10637784