Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Naoki Terayama"'
Autor:
Tadashi Shimizu, Kenichi Asano, Masahiro Takahashi, Takashi Suda, Shuhei Nakao, Mikiko Sodeoka, Megumi Magarisawa, Naoki Terayama, Kosuke Dodo, Satoshi Yotsumoto, Takuto Tokuhiro, Erika Kuboki, Masato Tanaka, Ryu Imamura
Publikováno v:
ACS Medicinal Chemistry Letters
The indolylmaleimide (IM) derivative IM-17 shows inhibitory activity against oxidative-stress-induced necrotic cell death and cardioprotective activity in rat ischemia-reperfusion injury models. In order to develop a more potent derivative, we conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af683b150aab9c622aec000bba003e2f
https://doi.org/10.1021/acsmedchemlett.9b00142
https://doi.org/10.1021/acsmedchemlett.9b00142
Autor:
Naoki Terayama, Koichi Fujiwara, Shuhei Nakao, Kosuke Dodo, Syusuke Egoshi, Yuki Tamura, Mikiko Sodeoka, Ayato Sato, Kana Oonuma
Publikováno v:
Chemical communications (Cambridge, England). 57(17)
γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity through unidentified mechanisms. Here, to assess the involvement of oxidized metabolites of GLA, we synthesized several deuterated GLAs and evaluated their metabolism and cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73f4bfd2375e3f67a28ae3802699b89
https://pubmed.ncbi.nlm.nih.gov/33527102
https://pubmed.ncbi.nlm.nih.gov/33527102
Autor:
Shigeomi Shimizu, Kosuke Dodo, Satoshi Yotsumoto, Makoto Arita, Yuito Muroi, Naoki Terayama, Tatsuya Chiba, Ryohei Aoyagi, Rio Ohmura, Maki Yoneyama, Mikiko Sodeoka, Satoko Arakawa, Masato Tanaka, Megumi Magarisawa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Scientific Reports
Scientific Reports
Because neutrophil extracellular trap (NET) formation is involved in the pathology of a wide variety of diseases, NET-regulating compounds are expected to be useful for the therapies of these diseases. In this study, we identified sulfasalazine (SSZ)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ab3faf6be38288364041425e5369f7
http://link.springer.com/article/10.1038/s41598-017-15668-z
http://link.springer.com/article/10.1038/s41598-017-15668-z
Autor:
Shinji Nagumo, Masaaki Miyashita, Megumi Mizukami, Daisuke Katsumi, Naoki Terayama, Kazuki Nakasone, Eiko Yasui
Publikováno v:
The Journal of organic chemistry. 84(3)
A new efficient synthesis of sekothrixide was established on the basis of our developed regioselective coupling of epoxy sec-alcohol with Gilman reagent guided by a TMS group. The new synthetic route allowed an overall yield of 6.3% (26 steps) from o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b8b47f38f1a577f848a08a36000e3e
https://pubmed.ncbi.nlm.nih.gov/30608691
https://pubmed.ncbi.nlm.nih.gov/30608691
Autor:
Mikiko Sodeoka, Kosuke Dodo, Shinya Fujishiro, Akihiro Ito, Yoshihiro Sohtome, Minoru Yoshida, Yoichi Shinkai, Joaquin Barjau, Mai Akakabe, Naoki Terayama, Tadahiro Shimazu
Publikováno v:
Chemical communications (Cambridge, England). 54(66)
We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ada6961039951f9f553b6f7d6772b3
https://pubmed.ncbi.nlm.nih.gov/30063235
https://pubmed.ncbi.nlm.nih.gov/30063235
Publikováno v:
Tetrahedron. 71:6594-6601
We have previously reported enantioselective reactions of 1,3-diketones and β-ketoesters with various electrophiles catalyzed by chiral Pd complex, in which chiral Pd enolates play a key role. Here, we present a detailed examination of Pd-catalyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12eab5b24f20cf2198d87e098e3e439c
https://doi.org/10.1016/j.tet.2015.07.002
https://doi.org/10.1016/j.tet.2015.07.002
Publikováno v:
Tetrahedron Letters. 55:6515-6519
Coupling reactions of epoxide linked to a secondary oxygen group with Gilman reagents were examined. The regiochemical direction depended on whether there is TMS or MOM as a protective group of the secondary alcohol. anti -Epoxy alcohol 6 tended to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b5b1b27db3638362c18fb4b4af9b4c
https://doi.org/10.1016/j.tetlet.2014.09.029
https://doi.org/10.1016/j.tetlet.2014.09.029
Publikováno v:
Organic Letters. 16:2794-2797
The first total synthesis of 14-membered macrolide sekothrixide and the originally proposed structure are reported. Seven contiguous asymmetric centers in the side chain were constructed using ring-openings of several kinds of epoxide. Assembly of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ce88f0ca95127d30cf8c8c46b386d1
https://doi.org/10.1021/ol5006856
https://doi.org/10.1021/ol5006856
Autor:
Kyoko Hiramatsu, Naoki Terayama, Shun-suke Moriya, Masao Kawakita, Eiko Yasui, Shinji Nagumo, Tatsuya Kiryu, Takato Kawanishi
Publikováno v:
ResearcherID
For the purpose of obtaining a creatinine-specific antibody, a creatinine derivative with 4-aminobutyl, which was served as a linker for preparing the creatinine-bovine serum albumin (BSA) conjugate, was synthesized from 4-benzylaminobutan-1-ol in 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b7a8707d9676a62298de13e50cba4d
https://doi.org/10.1248/cpb.c13-00960
https://doi.org/10.1248/cpb.c13-00960
Autor:
Masaaki Kurihara, Yukiko Sato, Wataru Hakamata, Haruhiro Okuda, Hideshi Inoue, Yosuke Demizu, Naoki Terayama, Kaichi Sano
Publikováno v:
Synthetic Communications. 42:1724-1730
This study demonstrates solid-phase nucleophilic fluorination. Polymer-bound 1-phenoxy-2-sulfonyloxyethane, as a model compound, is converted to a fluorinated compound in a short time. Furthermore, this method is applied to synthesize a precursor of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633769fb8790b9e77d1939e64cff9218
https://doi.org/10.1080/00397911.2010.535950
https://doi.org/10.1080/00397911.2010.535950