Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Naoki Takemura"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Humans are constantly exposed to various industrial, environmental, and endogenous particulates that result in inflammatory diseases. After being engulfed by immune cells, viz. Macrophages, such particulates lead to phagolysosomal dysfunc
Externí odkaz:
https://doaj.org/article/b29cb63609474557b4ac4ad9728a1c3c
Autor:
Erika Sugisawa, Takeshi Kondo, Yutaro Kumagai, Hiroki Kato, Yasunori Takayama, Kayako Isohashi, Eku Shimosegawa, Naoki Takemura, Yoshinori Hayashi, Takuya Sasaki, Mikaël M. Martino, Makoto Tominaga, Kenta Maruyama
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110462- (2022)
Summary: Nociceptors can fine-tune local or systemic immunity, but the mechanisms of nociceptive modulation in endotoxic death remain largely unknown. Here, we identified C-type lectin Reg3γ as a nociceptor-enriched hormone that protects the host fr
Externí odkaz:
https://doaj.org/article/eab16290279b42c39ee70f9d8694fbde
Autor:
Kenta Maruyama, Hiroyasu Kidoya, Naoki Takemura, Erika Sugisawa, Osamu Takeuchi, Takeshi Kondo, Mohammed Mansour Abbas Eid, Hiroki Tanaka, Mikaël M. Martino, Nobuyuki Takakura, Yasunori Takayama, Shizuo Akira, Alexis Vandenbon, Yutaro Kumagai
Publikováno v:
Cell Reports, Vol 32, Iss 2, Pp 107906- (2020)
Summary: Zinc finger protein St18 was initially reported as candidate tumor suppressor gene, and also suggested that fibroblast St18 positively regulates NF-κB activation. Despite the pleiotropic functions of St18, little is known about its roles in
Externí odkaz:
https://doaj.org/article/39335951d565447b9f5690311309b724
Autor:
Kenta Maruyama, Yasunori Takayama, Erika Sugisawa, Yu Yamanoi, Takashi Yokawa, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Naoki Takemura, Yuki Mori, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Yoshichika Yoshioka, Hisao Nishijo, Hiroki Tanaka, Atsushi Sasaki, Naohito Ohno, Yoichiro Iwakura, Yoshinori Moriyama, Masatoshi Nomura, Shizuo Akira, Makoto Tominaga
Publikováno v:
iScience, Vol 6, Iss , Pp 306-318 (2018)
Summary: Candida albicans infection can cause skin, vulvar, or oral pain. Despite the obvious algesic activity of C. albicans, the molecular mechanisms of fungal nociception remain largely unknown. Here we show that the C. albicans-specific signaling
Externí odkaz:
https://doaj.org/article/af790e5323b74bdb88c067532d689b01
Autor:
Yu Takahashi, Shintaro Sato, Yosuke Kurashima, Tomohisa Yamamoto, Shiho Kurokawa, Yoshikazu Yuki, Naoki Takemura, Satoshi Uematsu, Chen-Yi Lai, Makoto Otsu, Hiroshi Matsuno, Hideki Osawa, Tsunekazu Mizushima, Junichi Nishimura, Mikio Hayashi, Takayuki Yamaguchi, Hiroshi Kiyono
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 314-328 (2018)
Summary: Gut epithelial organoids are routinely used to investigate intestinal biology; however, current culture methods are not amenable to genetic manipulation, and it is difficult to generate sufficient numbers for high-throughput studies. Here, w
Externí odkaz:
https://doaj.org/article/c4006f10f2d34228a3837a3832bd0c9b
Autor:
Kenta Maruyama, Yasunori Takayama, Takeshi Kondo, Ken-ichi Ishibashi, Bikash Ranjan Sahoo, Hisashi Kanemaru, Yutaro Kumagai, Mikaël M. Martino, Hiroki Tanaka, Naohito Ohno, Yoichiro Iwakura, Naoki Takemura, Makoto Tominaga, Shizuo Akira
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2730-2742 (2017)
Candida albicans can enter skeletal tissue through a skin wound in an immunocompromised host or by contamination during orthopedic surgery. Such Candida osteomyelitis is accompanied by severe pain and bone destruction. It is established that nocicept
Externí odkaz:
https://doaj.org/article/1d2bc973c974426cb9cc52333f235fa0
Autor:
Rumi Higuchi, RMS, Hiroshi Tada, MD, Hiroki Okaniwa, RMS, Tsutomu Nakajima, CE, Naoki Takemura, MD, Etsuko Fuke, MD, Chizuru Sato, MD, Tatsuya Hayashi, MD, Yuko Miki, MD, Tamotsu Sakamoto, MD, Rie Fukasawa, MD, Koji Kumagai, MD, Shigeto Naito, MD, Shigeru Oshima, MD
Publikováno v:
Journal of Arrhythmia, Vol 27, Iss 2, Pp 120-125 (2011)
Background: Optimizing the atrio-ventricular delay (AVD) is important for increasing the left ventricular (LV) preload in patients receiving cardiac resynchronization therapy (CRT). The optimal AVD may be considered an AVD in which the maximum LV fil
Externí odkaz:
https://doaj.org/article/fce9d3761be84886ad5691c289cf6455
Autor:
Yudai Matsui, Naoki Takemura, Yoshitaka Shirasaki, Michihiro Takahama, Yoshihiko Noguchi, Kenta Ikoma, Yixi Pan, Shuhei Nishida, Manabu Taura, Akiyoshi Nakayama, Takashi Funatsu, Takuma Misawa, Yoshie Harada, Toshiaki Sunazuka, Tatsuya Saitoh
Publikováno v:
International Immunology. 34:505-518
Nod-like receptor family pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune receptor that senses organelle dysfunction induced by various stimuli, such as infectious, environmental, metabolic and drug stresses. Upon activation, NLRP3 form
Autor:
Naoki Takemura, Shintaro Terahata, Toshiko Kakiuchi, Yoshiko Takata, Hiroshi Kawai, Toshiyuki Okamura, Katsuhisa Inamura
Publikováno v:
Kanzo. 62:487-493
Autor:
Ayako Kaitani, Masato Kubo, Yoshimichi Okayama, Jiro Kitaura, Yukari Saito, Shizuo Akira, Sayuri Murasaki, Miho Nakamura, Takao Takahashi, Masahiro Kiuchi, Toshinori Nakayama, Kumiko Fujisawa, Kiyoshi Hirahara, Shota Toyoshima, Yosuke Kurashima, Kaoru Shimada, Kumi Izawa, Fujimi Arai, Naoki Takemura, Satoshi Uematsu, Jun Kunisawa, Yoshihiro Takasato, Hiroshi Kiyono
Publikováno v:
Mucosal Immunology
Oral immunotherapy (OIT) is an effective approach to controlling food allergy. Although the detailed molecular and cellular mechanisms of OIT are unknown currently, they must be understood to advance the treatment of allergic diseases in general. To