Výsledky vyhledávání - "Naoki Miyakoshi"

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability

Autor: Naoki Miyakoshi, Motoki Ochi, Toshiyuki Marumo, Misako Fukasawa, Takashi Hashihayata, Hiroki Urabe, Akiko Nozoe, Junichi Yamaguchi, Kohnosuke Kinoshita, Shigeyuki Chaki, Norikazu Ohtake, Hirohiko Hikichi

Publikováno v: European journal of medicinal chemistry. 203

We previously reported that MGS0008 is a selective group II metabotropic glutamate receptor (mGlu2/3 receptor) agonist that is effective in animal models of schizophrenia. MGS0008 is a highly hydrophilic glutamate analog and is therefore expected to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd7fdcf1e674d170275b8838d244759
https://pubmed.ncbi.nlm.nih.gov/32698110

Zobrazit plný text záznamu

Proton-Coupled Erythromycin Antiport at Rat Blood-Placenta Barrier

Autor: Noriaki Tanaka, Noriko Kose, Masatoshi Tomi, Yasuna Kobayashi, Emi Nakashima, Naoki Miyakoshi, Yoshimichi Sai, Akinori Takagi, Chisato Mukai, Kaori Ochi, Shinji Kitagaki, Tomohiro Nishimura

Publikováno v: Drug Metabolism and Disposition. 38:1576-1581

The aim of the present study was to characterize the mechanism of erythromycin transport at the blood-placenta barrier, using TR-TBT 18d-1 cells as a model of rat syncytiotrophoblasts. [(14)C]Erythromycin was taken up by TR-TBT 18d-1 cells with a Mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa23b390fc094f3f3b22c0f4cf4e265
https://doi.org/10.1124/dmd.110.033266

Zobrazit plný text záznamu

Analysis on Misconducts and Inappropriate Practices by Japan's Nuclear Power Utilities and Assessment of Their Corrective Measures

Autor: Naoki Miyakoshi, Michihiro Ozawa, Masaaki Tani, Naomichi Kanegae, Seishi Torikai, Haruki Madarame

Publikováno v: Transactions of the Atomic Energy Society of Japan. 9:347-359

On March 30, 2007, Japan's electric utilities reported the results of a complete review of their power-generating units to the Nuclear and Industrial Safety Agency of the Ministry of Economy, Trade, and Industry (METI). The Ethics Committee of the At

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b126ad88e5befd7f87079a26053fb4f
https://doi.org/10.3327/taesj.j09.016

Zobrazit plný text záznamu

ATP-Binding Cassette Transporter G2 Mediates the Efflux of Phototoxins on the Luminal Membrane of Retinal Capillary Endothelial Cells

Autor: Naoki Miyakoshi, Satoko Hori, Shinji Kitagaki, Sumio Ohtsuki, Masahiko Watanabe, Chisato Mukai, Tetsuya Terasaki, Masanori Tachikawa, Tomoko Asashima

Publikováno v: Pharmaceutical Research. 23:1235-1242

The purpose of this study was to clarify the localization and function of the ATP-binding cassette transporter G2 (ABCG2; BCRP/MXR/ABCP) in retinal capillary endothelial cells, which form the inner blood–retinal barrier, as an efflux transport syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7ee6183d9706b9d44ff3a4bb500388a
https://doi.org/10.1007/s11095-006-0067-2

Zobrazit plný text záznamu

Total Syntheses of Naturally Occurring Diacetylenic Spiroacetal Enol Ethers

Autor: Chisato Mukai, Naoki Miyakoshi, Daisuke Aburano

Publikováno v: The Journal of Organic Chemistry. 70:6045-6052

A highly stereoselective method for constructing a (2E)-methoxymethylidene-1,6-dioxaspiro[4.5]decane skeleton has been developed on the basis of the palladium(II)-catalyzed ring-closing reaction of the 3,4-dioxygenated-9-hydroxy-1-nonyn-5-one derivat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abd3b3306fba57d23413199e07aaa6d
https://doi.org/10.1021/jo050822k

Zobrazit plný text záznamu

Twisted S1 excited state geometries in 4-dimethylaminobenzonitrile and dimethylaniline: New -d6 origin bands

Autor: Hiroyuki Saigusa, Robert J. Gordon, Shigeru Kohtani, Naoki Miyakoshi, Chisato Mukai, Ryoichi Nakagaki, Tomoyoshi Fukagawa

Publikováno v: The Journal of Chemical Physics. 119:5414-5422

The S1←S0 electronic spectra of 4-dimethylaminobenzonitrile-h6 and -d6 (DMABN) and dimethylaniline-h6 and -d6 have been reexamined, and new electronic origins have been observed for the -d6 species, approximately 65 cm−1 lower in energy than prev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1e2fd9cc7cd11fb8422bf9747bfa1c9
https://doi.org/10.1063/1.1598959

Zobrazit plný text záznamu

First Total Synthesis of (−)-Ichthyothereol and Its Acetate

Autor: Miyoji Hanaoka, Chisato Mukai, Naoki Miyakoshi

Publikováno v: The Journal of Organic Chemistry. 66:5875-5880

The first and stereoselective total syntheses of (-)-ichthyothereol (1) and its acetate ((+)-2) were achieved by incorporation of the two chiral centers of diethyl L-tartrate. The starting diethyl L-tartrate was converted into trans-2-ethynyl-3-hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d23a0a33e4044f85060558a9317e2c
https://doi.org/10.1021/jo0104532

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání