Maternal and fetal outcomes in pregnant Japanese women with inflammatory bowel disease: our experience with a series of 23 cases

Autor: Naoki Minami, Minoru Matsuura, Yorimitsu Koshikawa, Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Hiroshi Nakase

Publikováno v: Intestinal Research, Vol 15, Iss 1, Pp 90-96 (2017)

Background/Aims: Our physicians work to expand the possibilities to treat female patients with inflammatory bowel disease (IBD) who wish to become pregnant. Although many drugs, including 5-aminosalicylate (5-ASA), corticosteroids, immunomodulators,

Externí odkaz: https://doaj.org/article/b7010b0ca9594dcd82f2f95506e4f78c

Efficacy and Safety of Long-Term Thiopurine Maintenance Treatment in Japanese Patients With Ulcerative Colitis

Autor: Satoshi Yamada, Takuya Yoshino, Minoru Matsuura, Masamichi Kimura, Yorimitsu Koshikawa, Naoki Minami, Takahiko Toyonaga, Yusuke Honzawa, Hiroshi Nakase

Publikováno v: Intestinal Research, Vol 13, Iss 3, Pp 250-258 (2015)

Background/AimsThe long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. The aim of this study was to assess the long-term efficacy and safety of maintenance treatment with

Externí odkaz: https://doaj.org/article/06131b10447443ad9c848f58a1cdd462

Diagnosis and Treatment of Ulcerative Colitis with Cytomegalovirus Infection: Importance of Controlling Mucosal Inflammation to Prevent Cytomegalovirus Reactivation

Autor: Hiroshi Nakase, Yusuke Honzawa, Takahiko Toyonaga, Satoshi Yamada, Naoki Minami, Takuya Yoshino, Minoru Matsuura

Publikováno v: Intestinal Research, Vol 12, Iss 1, Pp 5-11 (2014)

Human cytomegalovirus (HCMV) is a member of the herpesvirus family. HCMV infection persists throughout the host lifespan in a latent state following primary infection. The ability of HCMV to escape control by the host immune system and its resulting

Externí odkaz: https://doaj.org/article/ea5f02cbb123484a994be6894ba2da0d

Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity.

Autor: Takahiko Toyonaga, Hiroshi Nakase, Satoru Ueno, Minoru Matsuura, Takuya Yoshino, Yusuke Honzawa, Ayako Itou, Kazuyoshi Namba, Naoki Minami, Satoshi Yamada, Yorimitsu Koshikawa, Toshimitsu Uede, Tsutomu Chiba, Kazuichi Okazaki

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0135552 (2015)

Osteopontin (OPN) is a multifunctional protein expressed in a variety of tissues and cells. Recent studies revealed increased OPN expression in the inflamed intestinal tissues of patients with inflammatory bowel disease (IBD). The role of OPN in the

Externí odkaz: https://doaj.org/article/33ad230abda14bc1b5c4323b834a66c3

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome ActivationSummary

Autor: Naoki Minami, Hisanori Horiuchi, Kohei Wagatsuma, Daisuke Hirayama, Ryutaro Shirakawa, Tomoya Iida, Seiichi Hirota, Hiroki Ikeuchi, Minoru Matsuura, Hiroshi Nakase, Kentaro Kawakami, Masanori Nojima, Kanna Nagaishi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 2, Pp 277-293 (2020)
Cellular and Molecular Gastroenterology and Hepatology

Background & Aims Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily. Ral regulates tumorigenesis and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d16d8f812582cc3f7b9947159562783
http://www.sciencedirect.com/science/article/pii/S2352345X19301390