Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Naoki Katsumata"'
Autor:
Kenji Miyata, Xuchen Zhou, Tohru Yamawaki, Hiroaki Shimokawa, Kensuke Egashira, Akira Takeshita, Ikuko Kunihiro, Naoki Katsumata, Taiki Higo, Eriko Tanaka
Publikováno v:
Circulation. 100:1432-1437
Background —The question of whether or not endothelial vasodilator function in the spastic coronary artery is preserved is still controversial. We recently developed a porcine model in which long-term and local treatment with interleukin-1β (IL-1
Publikováno v:
Cardiovascular Drugs and Therapy. 6:611-622
In beagle dogs anesthetized with enflurane-nitrous oxide, effects of sodium nitroprusside (SNP; MR7S1) and nitroglycerin (NTG) on hemodynamics and main organ circulation were studied to evaluate their effectiveness and safety as hypotensive agents du
Publikováno v:
European journal of pharmacology. 398(1)
Diltiazem has cardioprotective properties following myocardial ischemic injury. However, there are controversial results regarding the beneficial effects of diltiazem on regional myocardial flow after ischemia. Therefore, we investigated the effect o
Autor:
Eriko Tanaka, Yoshiaki Takamura, Naoki Katsumata, Taiki Higo, Hiroaki Shimokawa, Tohru Yamawaki, Tadashi Kandabashi, Akira Takeshita, Kenji Yogo, Kenji Miyata, Kensuke Egashira
Publikováno v:
Journal of cardiovascular pharmacology. 35(2)
Serotonin is one of the most important vasoactive substances and has been implicated in the pathogenesis of coronary artery spasm and of acute coronary syndrome. We have recently demonstrated that local and long-term treatment with interleukin-1beta(
Autor:
Kozo Kaibuchi, Akira Takeshita, Kouichi Kuwata, Kensuke Egashira, Naoki Katsumata, Toshiyuki Kozai, Minoru Seto, Hiroaki Shimokawa, Ichiro Ikegaki, Mutsuki Amano, Tadashi Kandabashi, T. Asano, Tohru Yamawaki
Publikováno v:
Cardiovascular research. 43(4)
Objective: We recently demonstrated in our swine model of coronary artery spasm that enhanced myosin light chain (MLC) phosphorylations (both MLC mono- and diphosphorylations) play a central role in the pathogenesis of the spasm. However, the molecul
Autor:
Toshiyuki Kozai, Yasuharu Sasaki, T. Asano, Hiroaki Shimokawa, Ichiro Ikegaki, Kouichi Kuwata, Akira Takeshita, Naoki Katsumata, Tohru Yamawaki, Minoru Seto, Kensuke Egashira
Publikováno v:
Circulation. 96(12)
Background Although coronary artery spasm plays an important role in a wide variety of ischemic heart diseases, the intracellular mechanism for the spasm remains to be clarified. We examined the role of myosin light chain (MLC) phosphorylations, a ke
Autor:
Naoki Katsumata, Hiroaki Shimokawa, Kouichi Kuwata, Toshiaki Kadokami, Tohru Yamawaki, Akira Takeshita, Kensuke Egashira, Toshiyuki Kozai, Yoshihiro Fukumoto
Publikováno v:
Coronary artery disease. 8(7)
Background Although platelet activating factor (PAF) is an important vasoactive substance released from activated leukocytes, platelets and endothelial cells, little is known about its effect at the inflammatory coronary lesions in vivo. Objective To
Autor:
NAOKI KATSUMATA
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 32:17S-18S
Autor:
Takaharu Ishibashi, Masayasu Okuhira, Masami Hamaguchi, Naoki Katsumata, Mikio Nakazawa, Shoichi Imai
Publikováno v:
Japanese journal of pharmacology. 55(1)
We studied the effect of carvedilol, a beta-blocker with a potent alpha-blocking activity, on venous return in anesthetized dogs. Though 3 micrograms/kg of carvedilol caused a slight increase in blood pressure and total peripheral resistance, these c
Publikováno v:
Cardiovascular research. 24(12)
Study objective – The aim was to investigate the effects of a newly synthesised bradycardic agent, FR 76830, on cardiac mechanical function and metabolism during ischaemia and reperfusion. Design – FR 76830 and diltiazem were infused during 15 mi