Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Naoki Honkura"'
Autor:
Naoki Honkura, Mark Richards, Bàrbara Laviña, Miguel Sáinz-Jaspeado, Christer Betsholtz, Lena Claesson-Welsh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Different stimuli can induce dynamic changes in blood flow velocity, vessel diameter and permeability. Here the authors develop a multi-photon microscopy-based image analysis tool allowing the identification of vessels and the assessment of rapid cha
Externí odkaz:
https://doaj.org/article/5f724ed68afa4984a0c4a2a53150e86d
Autor:
Xiujuan Li, Narendra Padhan, Elisabet O. Sjöström, Francis P. Roche, Chiara Testini, Naoki Honkura, Miguel Sáinz-Jaspeado, Emma Gordon, Katie Bentley, Andrew Philippides, Vladimir Tolmachev, Elisabetta Dejana, Radu V. Stan, Dietmar Vestweber, Kurt Ballmer-Hofer, Christer Betsholtz, Kristian Pietras, Leif Jansson, Lena Claesson-Welsh
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Signals through VEGF receptor 2 (VEGFR2) increase vascular permeability, promoting cancer progression. Here the authors show that a point mutation in VEGFR2 preventing its auto-phosphorylation leads to reduced metastatic spread and improved response
Externí odkaz:
https://doaj.org/article/b507e4a16cf547ee96f8120a0c5f0330
Publikováno v:
Thrombosis and haemostasis.
Background Thrombomodulin (TM) functions as a dual modulator—anticoagulant and antifibrinolytic potential—by the thrombin-dependent activation of protein C and thrombin-activatable fibrinolysis inhibitor (TAFI). Activated TAFI cleaves the C-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32ccb8ce033a72b7af9cb0bdbe1e828
https://pubmed.ncbi.nlm.nih.gov/36307100
https://pubmed.ncbi.nlm.nih.gov/36307100
Publikováno v:
Blood Adv
Our previous real-time imaging studies directly demonstrated the spatiotemporal regulation of clot formation and lysis by activated platelets. In addition to their procoagulant functions, platelets enhanced profibrinolytic potential by augmenting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc25f6b7356e7f60cb19602c66ef4e62
https://doi.org/10.1182/bloodadvances.2020002923
https://doi.org/10.1182/bloodadvances.2020002923
Autor:
Nitty Skariah Mathews, Yuko Suzuki, Naoki Honkura, Hideto Sano, Toshihide Iwashita, Tetsumei Urano
Publikováno v:
Thrombosis research. 210
Thrombolysis using recombinant tissue-type plasminogen activator (rt-PA) is the pharmacological treatment of choice in acute thrombotic events. However, a narrow therapeutic window and bleeding complications limit its use. We describe the role of car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d29931bc49c975c240212eccb9a4672
https://pubmed.ncbi.nlm.nih.gov/35030422
https://pubmed.ncbi.nlm.nih.gov/35030422
Autor:
Tetsumei Urano, Francis J. Castellino, Yuko Suzuki, Hideto Sano, Takayuki Iwaki, Naoki Honkura
Publikováno v:
Curr Drug Targets
The fibrinolytic system consists of a balance between rates of plasminogen activation and fibrin degradation, both of which are finely regulated by spatio-temporal mechanisms. Three distinct inhibitors of the fibrinolytic system that differently regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d412ec99e4a473ba22d85dc163dca748
https://doi.org/10.2174/1389450120666190715102510
https://doi.org/10.2174/1389450120666190715102510
Autor:
Naoki Honkura
Publikováno v:
Japanese Journal of Thrombosis and Hemostasis. 30:529-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30160ff35777d4f7a9161bee1eaaa490
https://doi.org/10.2491/jjsth.30.529
https://doi.org/10.2491/jjsth.30.529
Publikováno v:
Thrombosis and haemostasis. 122(3)
Background Details of the molecular interaction between tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor type-1 (PAI-1) remain unknown. Methods and Results Three distinct forms of high-molecular-weight complexes are demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bae480b42e6542409bb57cf11d77aa
https://pubmed.ncbi.nlm.nih.gov/33984865
https://pubmed.ncbi.nlm.nih.gov/33984865
Autor:
Tetsumei Urano, Hideto Sano, Yuko Suzuki, Hiroki Tanaka, Naoki Honkura, Takahiro Horinouchi, Naoki Unno, Soichi Miwa
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
In this study, we investigated how carbonylation of fibrinogen by acrolein modified its indispensable function to enhance fibrinolysis after being converted to fibrin and contributed to generating a fibrinolysis-resistant fibrin clot. Acrolein-treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4187f98243493ba9f19b2ea18ed6be5
http://europepmc.org/articles/PMC7691368
http://europepmc.org/articles/PMC7691368
Autor:
Bàrbara Laviña, Naoki Honkura, Miguel Sáinz-Jaspeado, Mark Richards, Lena Claesson-Welsh, Christer Betsholtz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications
Nature Communications
The vasculature undergoes changes in diameter, permeability and blood flow in response to specific stimuli. The dynamics and interdependence of these responses in different vessels are largely unknown. Here we report a non-invasive technique to study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73782fe58d651c897787df8e37c7c02
http://link.springer.com/article/10.1038/s41467-018-04929-8
http://link.springer.com/article/10.1038/s41467-018-04929-8