Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Naoki Fujitsuka"'
Autor:
Sayako Yoshita, Satoko Osuka, Tomofumi Shimizu, Naoki Fujitsuka, Chinami Matsumoto, Bayasula, Natsuki Miyake, Ayako Muraoka, Natsuki Nakanishi, Tomoko Nakamura, Maki Goto, Hiroaki Kajiyama
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundPolycystic ovary syndrome (PCOS) is a common disorder resulting in irregular menstruation and infertility due to improper follicular development and ovulation. PCOS pathogenesis is mediated by downregulated follicle-stimulating hormone rece
Externí odkaz:
https://doaj.org/article/ff67420a281e4970b8c1e14ef4a07e2b
Autor:
Shinichi Morita, Akira Sakamaki, Kyutaro Koyama, Osamu Shibata, Takashi Owaki, Chiyumi Oda, Atsushi Kimura, Taiki Nakaya, Katsuya Ohbuchi, Miwa Nahata, Naoki Fujitsuka, Norihiro Sakai, Hiroyuki Abe, Kenya Kamimura, Shuji Terai
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines, is a drug that is expected to have therapeutic effects on obesity. Here, we report the eff
Externí odkaz:
https://doaj.org/article/67301e9c2c9f4dc4b4294f39c02532c1
Autor:
Peilin Li, Yusuke Inoue, Daisuke Miyamoto, Toshiyuki Adachi, Satomi Okada, Tomohiko Adachi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Shinichiro Ito, Daichi Sadatomi, Sachiko Mogami, Naoki Fujitsuka, Weili Gu, Susumu Eguchi
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283626 (2023)
BackgroundDaikenchuto (DKT) has positive therapeutic effects on improving various gastrointestinal disorders. The present study investigated whether or not DKT has a potential therapeutic effect on chemotherapy-induced acute small intestinal mucositi
Externí odkaz:
https://doaj.org/article/56de2469e52044a49bd7fff4df3734d2
Autor:
Takahiro Iwasawa, Shunsuke Nojiri, Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Masahiro Ogawa, Satoko Motegi, Takeki Sato, Masaru Kumagai, Taiki Nakaya, Katsuya Ohbuchi, Miwa Nahata, Naoki Fujitsuka, Masaaki Takamura, Shuji Terai
Publikováno v:
Regenerative Therapy, Vol 18, Iss , Pp 231-241 (2021)
Background: Liver cirrhosis is an end-stage multiple liver disease. Mesenchymal stem cells (MSCs) are an attractive cell source for reducing liver damage and regressing fibrosis; additional therapies accompanying MSCs can potentially enhance their th
Externí odkaz:
https://doaj.org/article/1656415cb147473db64c3acf63d3718d
Autor:
Miwa Nahata, Sachiko Mogami, Hitomi Sekine, Seiichi Iizuka, Naoto Okubo, Naoki Fujitsuka, Hiroshi Takeda
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Chronic undernutrition contributes to the increase in frailty observed among elderly adults, which is a pressing issue in the sector of health care for older people worldwide. Autophagy, an intracellular recycling system, is closely associat
Externí odkaz:
https://doaj.org/article/2976f3861c604a40a8c972724066b04e
Autor:
Taro Oshiro, Yumi Harada, Kunitsugu Kubota, Daichi Sadatomi, Hitomi Sekine, Mitsue Nishiyama, Naoki Fujitsuka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 152, Iss , Pp 113263- (2022)
Changes in the intestinal microbiota are known to occur in constipated patients. Dietary fiber restriction presents obstacles to appropriate defecation and affects fecal properties, but the relationship between fecal microbiota and fecal morphologica
Externí odkaz:
https://doaj.org/article/aceae46b608c4adc9886e79375d236e7
Autor:
Norihiro Okada, Kenshiro Oshima, Yuki Iwasaki, Akiko Maruko, Kenya Matsumura, Erica Iioka, Trieu-Duc Vu, Naoki Fujitsuka, Akinori Nishi, Aiko Sugiyama, Mitsue Nishiyama, Atsushi Kaneko, Kazushige Mizoguchi, Masahiro Yamamoto, Susumu Nishimura
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108197- (2022)
We performed RNA-seq analyses of mRNA isolated from five organs, liver, bone, heart, kidney and blood at the pre-symptomatic state of klotho mice with/without administration of a Japanese traditional herbal medicine, juzentaihoto (JTT). Data of diffe
Externí odkaz:
https://doaj.org/article/57bf8c5809b5465e8984397747055bf4
Autor:
Miwa Nahata, Naoki Fujitsuka, Hitomi Sekine, Chika Shimobori, Katsuya Ohbuchi, Seiichi Iizuka, Sachiko Mogami, Shunsuke Ohnishi, Hiroshi Takeda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Malnutrition impairs basic daily activities and leads to physical frailty, which is aggravated in the elderly compared with young adults. It is also well-known that the elderly are more vulnerable to metabolic stress. Therefore, in this study, using
Externí odkaz:
https://doaj.org/article/826f08799ed24f58a4c998facfea729e
Autor:
Sotaro Ozaka, Akira Sonoda, Shimpei Ariki, Mizuki Minata, Naganori Kamiyama, Shinya Hidano, Nozomi Sachi, Kanako Ito, Yoko Kudo, Astri Dewayani, Thanyakorn Chalalai, Takashi Ozaki, Yasuhiro Soga, Chiaki Fukuda, Kazuhiro Mizukami, Shiori Ishizawa, Mitsue Nishiyama, Naoki Fujitsuka, Sachiko Mogami, Kunitsugu Kubota, Kazunari Murakami, Takashi Kobayashi
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269698 (2022)
Antibiotics disrupt normal gut microbiota and cause dysbiosis, leading to a reduction in intestinal epithelial barrier function. Disruption of the intestinal epithelial barrier, which is known as "leaky gut", results in increased intestinal permeabil
Externí odkaz:
https://doaj.org/article/f369040e15784bfea8b39771f9a9e1cb
Autor:
Yumi Harada, Hitomi Sekine, Kunitsugu Kubota, Daichi Sadatomi, Seiichi Iizuka, Naoki Fujitsuka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111860- (2021)
EGFR tyrosine kinase inhibitors (TKIs) are mainly used to treat non-small cell lung cancer; however, adverse effects such as severe diarrhea represent a major obstacle towards the continuation of EGFR-TKIs therapy. Chloride channels, which control th
Externí odkaz:
https://doaj.org/article/f7fd0d0cf52a4ee58a9b95b1c6bf2a17