Synergistic anti‐depressive effect of combination treatment of Brexpiprazole and selective serotonin reuptake inhibitors on forced swimming test in mice

Autor: Naoki Amada, Tsuyoshi Hirose, Mikio Suzuki, Yusuke Kakumoto, Takashi Futamura, Kenji Maeda, Tetsuro Kikuchi

Publikováno v: Neuropsychopharmacology Reports, Vol 43, Iss 1, Pp 132-136 (2023)

Abstract Aim Selective serotonin reuptake inhibitors (SSRIs) are used to treat major depressive disorder (MDD) and other psychiatric disorders (e.g., obsessive compulsive disorder, social anxiety disorder, and panic disorder). In MDD treatment, SSRIs

Externí odkaz: https://doaj.org/article/539a2a2ea0d34f5d8379ae7d122281e2

Brexpiprazole has a low risk of dopamine D2 receptor sensitization and inhibits rebound phenomena related to D2 and serotonin 5‐HT2A receptors in rats

Autor: Naoki Amada, Hitomi Akazawa, Yuta Ohgi, Kenji Maeda, Haruhiko Sugino, Nobuyuki Kurahashi, Tetsuro Kikuchi, Takashi Futamura

Publikováno v: Neuropsychopharmacology Reports, Vol 39, Iss 4, Pp 279-288 (2019)

Abstract Background Long‐term antipsychotic treatment in patients with schizophrenia can induce supersensitivity psychosis and tardive dyskinesia which is thought to be caused by dopamine D2 receptor sensitization. We evaluated the effects of brexp

Externí odkaz: https://doaj.org/article/66b91c71c5e2434aa05a0dc090222e04

Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression

Autor: Naoki Amada, Yuki Yamasaki, Claire M. Williams, Benjamin J. Whalley

Publikováno v: PeerJ, Vol 1, p e214 (2013)

To date, anticonvulsant effects of the plant cannabinoid, cannabidivarin (CBDV), have been reported in several animal models of seizure. However, these behaviourally observed anticonvulsant effects have not been confirmed at the molecular level. To e

Externí odkaz: https://doaj.org/article/961f3fd787e046f6b65dbb98ac413e73

MK-801-induced deficits in social recognition in rats

Autor: Yuki Yamasaki, Gernot Riedel, Tetsuro Kikuchi, Naoki Amada, Akihito Watanabe, Serena Deiana, Colin Stott

Publikováno v: Behavioural Pharmacology. 26:748-765

Deficiencies in social activities are hallmarks of numerous brain disorders. With respect to schizophrenia, social withdrawal belongs to the category of negative symptoms and is associated with deficits in the cognitive domain. Here, we used the N-me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478691866636ab6d642198ab1f79ce7a
https://doi.org/10.1097/fbp.0000000000000178

A Low Mortality, High Morbidity Reduced Intensity Status Epilepticus (RISE) Model of Epilepsy and Epileptogenesis in the Rat

Autor: Naoki Amada, Gavin L. Woodhall, Tamara Modebadze, Isabelle A. A. Pérès, Christopher Morris, Nicola H. Morgan, Benjamin J. Whalley, Rebecca Hadid, Claire M. Williams, Charlotte L Hill, Roland S.G. Jones, Ian M. Stanford

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0147265 (2016)
PLoS ONE
Modebadze, T, Morgan, N H, Pérès, I A A, Hadid, R D, Amada, N, Hill, C, Williams, C, Stanford, I M, Morris, C M, Jones, R S G, Whalley, B J & Woodhall, G L 2016, ' A low mortality, high morbidity reduced intensity status epilepticus (RISE) model of epilepsy and epileptogenesis in the rat ', PLoS ONE, vol. 11, no. 2, e0147265 . https://doi.org/10.1371/journal.pone.0147265

Animal models of acquired epilepsies aim to provide researchers with tools for use in understanding the processes underlying the acquisition, development and establishment of the disorder. Typically, following a systemic or local insult, vulnerable b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b19e1fdd0bedc743a3267372134b8f
http://europepmc.org/articles/PMC4765932?pdf=render