SARS-CoV-2 infection causes a decline in renal megalin expression and affects vitamin D metabolism in the kidney of K18-hACE2 mice

Autor: Yoshifumi Kurosaki, Toshihide Matsumoto, Takayuki Uematsu, Fumitaka Kawakami, Rei Kawashima, Shun Tamaki, Motoki Imai, Takafumi Ichikawa, Naohito Ishii, Hidero Kitasato, Hideaki Hanaki, Makoto Kubo

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Patients with coronavirus disease 2019 (COVID-19) often experience acute kidney injury, linked to disease severity or mortality, along with renal tubular dysfunction and megalin loss in proximal tubules. Megalin plays a crucial role in kidne

Externí odkaz: https://doaj.org/article/9a125330bf3c4b01b3dba2ec50c5d2d2

Calcitriol Supplementation Improves Endothelium-Dependent Vasodilation in Rat Hypertensive Renal Injury

Autor: Tsuneo Takenaka, Tsutomu Inoue, Yoichi Ohno, Takashi Miyazaki, Akira Nishiyama, Naohito Ishii, Hiromichi Suzuki

Publikováno v: Kidney & Blood Pressure Research, Vol 39, Iss 1, Pp 17-27 (2014)

Background/Aims: Vitamin D increases renal expression of klotho in normotensive rats. Klotho reduces oxidative stress. Methods: In this study, we aimed to determine if vitamin D would suppress oxidative stress using 4 groups of hypertensive rats: uni

Externí odkaz: https://doaj.org/article/c4d959cd729243abb62e8f8d9b386972

MO455: Fatty Acid-Associated Albumin Induces Proliferation and Senescence of Proximal Tubular Cells

Autor: Yoshifumi Kurosaki, Rikke Nielsen, Motoshi Ouchi, Asuka Morita, Akemi Imoto, Fumitaka Kawakami, Yoshiko Iizuka, Geraldine Mollet, Takafumi Ichikawa, Masanori Yokoba, Masato Katagiri, Tsuneo Takenaka, Naohito Ishii

Publikováno v: Nephrology Dialysis Transplantation. 37

BACKGROUND AND AIMS Proteinuria is a major risk factor for the progression of chronic kidney disease. Protein overload in the proximal tubular epithelial cells causes oxidative stress, lysosomal dysfunction, inflammation and apoptosis, resulting in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b7caaf3cffaffb7dbcd09d374b3bd62
https://doi.org/10.1093/ndt/gfac070.069

In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells

Autor: Yoshifumi Kurosaki, Akemi Imoto, Fumitaka Kawakami, Motoshi Ouchi, Asuka Morita, Masanori Yokoba, Tsuneo Takenaka, Takafumi Ichikawa, Masato Katagiri, Rikke Nielsen, Naohito Ishii

Publikováno v: Kurosaki, Y, Imoto, A, Kawakami, F, Ouchi, M, Morita, A, Yokoba, M, Takenaka, T, Ichikawa, T, Katagiri, M, Nielsen, R & Ishii, N 2022, ' In vitro study on effect of bardoxolone methyl on cisplatin-induced cellular senescence in human proximal tubular cells ', Molecular and Cellular Biochemistry, vol. 477, no. 3, pp. 689-699 . https://doi.org/10.1007/s11010-021-04295-y

Bardoxolone methyl [methyl-2-cyano-3, 12-dioxooleana-1, 9(11)dien-28-oate (CDDO-Me)], an activator of the nuclear factor erythroid-derived 2-related factor2 pathway, is a potential therapeutic candidate for the treatment of kidney diseases. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d0d631b5e3df726d8a397f745b2745
https://pure.au.dk/portal/da/publications/in-vitro-study-on-effect-of-bardoxolone-methyl-on-cisplatininduced-cellular-senescence-in-human-proximal-tubular-cells(15a7ae91-ea63-40c8-b528-d1d019cefdeb).html

Klotho Ameliorates Medullary Fibrosis and Pressure Natriuresis in Hypertensive Rat Kidneys

Autor: Akira Nishiyama, Matsuhiko Hayashi, Tsutomu Inoue, Naohito Ishii, Hiroyuki Kobori, Hiromichi Suzuki, Takashi Miyazaki, Tsuneo Takenaka

Publikováno v: Hypertension. 72:1151-1159

Renal expression of klotho is reduced in hypertension. Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca21412e6d2cd4562b444b6e68945cd9
https://doi.org/10.1161/hypertensionaha.118.11176