Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Naohisa Niiro"'
Publikováno v:
Advances in Hematology, Vol 2023 (2023)
Background. Tokunoshima is a remote island in the Amami Islands, 470 km southwest of the Kagoshima mainland. It has a population of 23,000 and consists of three towns: Tokunoshima, Isen, and Amagi. Three medical institutions on the island are respons
Externí odkaz:
https://doaj.org/article/29735104c3c64f93a6d768ffe682aec7
Publikováno v:
British Journal of Pharmacology. 151:1014-1024
Background and purpose: The intravesical administration of dimethyl sulphoxide (DMSO) is used to alleviate the symptoms of interstitial cystitis. We investigated the relaxant effect of DMSO and its underlying mechanism in the detrusor muscle. Experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c5fa566e1e4655de849ebd27bee9c4a
https://doi.org/10.1038/sj.bjp.0707317
https://doi.org/10.1038/sj.bjp.0707317
Publikováno v:
Circulation Research. 96:890-897
Vascular smooth muscle cells (VSMCs) have a remarkable degree of plasticity and in response to vascular injury, they can change to a dedifferentiated state that can be typically seen in cell cultures. Recently, Y27632, a Rho kinase inhibitor, has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d700be290129c6a2b1ea6fe1a1591b
https://doi.org/10.1161/01.res.0000163018.66460.85
https://doi.org/10.1161/01.res.0000163018.66460.85
Publikováno v:
Biochemical Journal. 369:117-128
The inhibition of myosin light chain phosphatase (MLCP) enhances smooth muscle contraction at a constant [Ca2+]. There are two components, myosin-binding subunit of MLCP (MBS) and CPI17, thought to be responsible for the inhibition of MLCP by externa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f1c6dd9b231116eef0810455e903b7
https://doi.org/10.1042/bj20021040
https://doi.org/10.1042/bj20021040
Publikováno v:
FEBS Letters. 515:127-132
Dephosphorylation of the two key regulatory factors of myosin light chain phosphatase (MLCP), CPI17 and MBS (myosin binding subunit) of MLCP was studied. While Thr38 phosphorylated CPI17 is quite susceptible to protein phosphatases, phosphorylated MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d741f2f190d0dbd4b6df7addf7a771bb
https://doi.org/10.1016/s0014-5793(02)02451-1
https://doi.org/10.1016/s0014-5793(02)02451-1
Autor:
Mitsuo Ikebe, Naohisa Niiro
Publikováno v:
Journal of Biological Chemistry. 276:29567-29574
The inhibition of myosin phosphatase evokes smooth muscle contraction in the absence of Ca(2+), yet the underlying mechanisms are not understood. To this end, we have cloned smooth muscle zipper-interacting protein (ZIP) kinase cDNA. ZIP kinase is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386df249c8fb5eb6df174285896d2dd3
https://doi.org/10.1074/jbc.m102753200
https://doi.org/10.1074/jbc.m102753200
Autor:
Yoshinobu Shintani, Naohisa Niiro, Hitoo Nakano, Katsuya Hirano, Junji Nishimura, Hideo Kanaide
Publikováno v:
British Journal of Pharmacology. 130:1165-1173
Using fura-PE3 fluorimetry and α-toxin permeabilization, the characteristics of the contractile responses to neurokinin A (NKA) were determined in the pregnant rat myometrium. NKA induced contractions in rat myometrium in a concentration-dependent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c873c6778a91f25681680c75cbf3bb0f
https://doi.org/10.1038/sj.bjp.0703410
https://doi.org/10.1038/sj.bjp.0703410
Autor:
David J. Hartshorne, Mayumi Hirano, Junji Nishimura, Katsuya Hirano, Hideo Kanaide, Naohisa Niiro
Publikováno v:
Biochemical and Biophysical Research Communications. 254:490-496
In endothelial cells in situ and in primary culture, immunoblot analysis revealed an expression of the 130-kDa subunit of myosin phosphatase, similar to the myosin phosphatase targeting subunit (MYPT) of smooth muscle. Screening of an endothelial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c293531a4deb2ab6ae71ca5553cbadd7
https://doi.org/10.1006/bbrc.1998.9973
https://doi.org/10.1006/bbrc.1998.9973
Publikováno v:
British Journal of Pharmacology. 124:1623-1632
A neuropeptide, galanin, regulates the reproductive process and directly induces myometrial contraction. The aim of this study was to determine the mechanism of galanin-induced myometrial contraction. For this purpose, we simultaneously measured intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14058c9478f3aea7bd0505323f275e96
https://doi.org/10.1038/sj.bjp.0702004
https://doi.org/10.1038/sj.bjp.0702004
Publikováno v:
The Journal of Urology. :2197-2201
To investigate the expression of beta-adrenoceptor (AR) subtypes responsible for detrusor smooth muscle relaxation.Isolated rat detrusor smooth muscle was examined by tension measurement and reverse transcription polymerase chain reaction (RT-PCR).No
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1201160bea64b157ea7bbf3e35876a55
https://doi.org/10.1097/00005392-199806000-00148
https://doi.org/10.1097/00005392-199806000-00148