Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Naohiro Yano"'
Publikováno v:
Pathophysiology, Vol 29, Iss 3, Pp 471-485 (2022)
Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of acetyl functional groups from lysine residues of histone and non-histone proteins. There are 18 mammalian HDACs, which are classified into four classes based on th
Externí odkaz:
https://doaj.org/article/199d81cb429d475f94f8f47439dfe8fb
Publikováno v:
Endocrines, Vol 2, Iss 3, Pp 266-283 (2021)
Irisin is a myokine that primarily targets adipose tissue, where it increases energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissue. As our knowledge has deepened in recent years, muscle
Externí odkaz:
https://doaj.org/article/df48ab7a185540aa841a9357771260dc
Autor:
Naohiro Yano, Alexey V. Fedulov
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1334 (2023)
Aberrant DNA hypermethylation at regulatory cis-elements of particular genes is seen in a plethora of pathological conditions including cardiovascular, neurological, immunological, gastrointestinal and renal diseases, as well as in cancer, diabetes a
Externí odkaz:
https://doaj.org/article/b52c1a3bf3d34f739ae53b67a955c2ae
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6145 (2023)
Particulate matter in the air exacerbates airway inflammation (AI) in asthma; moreover, prenatal exposure to concentrated urban air particles (CAPs) and diesel exhaust particles (DEPs) predisposes the offspring to asthma and worsens the resolution of
Externí odkaz:
https://doaj.org/article/5c71d602048d4e96971b4c1087f7bf35
Autor:
Supaporn Kulthinee, Lijiang Wang, Naohiro Yano, Patrycja M. Dubielecka, Ling X. Zhang, Shougang Zhuang, Gangjian Qin, Yu Tina Zhao, Yue Eugene Chin, Ting C. Zhao
Publikováno v:
Pharmaceuticals, Vol 15, Iss 10, p 1193 (2022)
Irisin, a cleaved product of the fibronectin type III domain containing protein-5, is produced in the muscle tissue, which plays an important role in modulating insulin resistance. However, it remains unknown if irisin provides a protective effect ag
Externí odkaz:
https://doaj.org/article/f22b49d30b124802ad0b404652f556b9
Autor:
Nicole E. James, Matthew T. Oliver, Jennifer R. Ribeiro, Evelyn Cantillo, Rachael B. Rowswell-Turner, Kyu-Kwang Kim, Clinton O. Chichester, Paul A. DiSilvestro, Richard G. Moore, Rakesh K. Singh, Naohiro Yano, Ting C. Zhao
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
While selective overexpression of serum clinical biomarker Human epididymis secretory protein 4 (HE4) is indicative of ovarian cancer tumorigenesis, much is still known about the mechanistic role of the HE4 gene or gene product. Here, we examine the
Externí odkaz:
https://doaj.org/article/1d40d022ef174c3eb530873e0bececed
Autor:
Jennifer R. Ribeiro, Hilary M. Gaudet, Mehreen Khan, Christoph Schorl, Nicole E. James, Matthew T. Oliver, Paul A. DiSilvestro, Richard G. Moore, Naohiro Yano
Publikováno v:
Frontiers in Oncology, Vol 7 (2018)
Human epididymis protein 4 (HE4) has received much attention recently due to its diagnostic and prognostic abilities for epithelial ovarian cancer. Since its inclusion in the Risk of Ovarian Malignancy Algorithm (ROMA), studies have focused on its fu
Externí odkaz:
https://doaj.org/article/35ddc51ef9b84832a570f414c883d609
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104888 (2014)
Doxorubicin (Dox) is one of the most widely used antitumor drugs, but its cumulative cardiotoxicity have been major concerns in cancer therapeutic practice for decades. Recent studies established that metformin (Met), an oral anti-diabetic drug, prov
Externí odkaz:
https://doaj.org/article/b01349d42a3d47bcb2a039930cb20d50
Autor:
Richard G Moore, Thilo S Lange, Katina Robinson, Kyu K Kim, Alper Uzun, Timothy C Horan, Nada Kawar, Naohiro Yano, Sharon R Chu, Quanfu Mao, Laurent Brard, Monique E DePaepe, James F Padbury, Leggy A Arnold, Alexander Brodsky, Tun-Li Shen, Rakesh K Singh
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34443 (2012)
BACKGROUND:Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of er
Externí odkaz:
https://doaj.org/article/1ab19dbd7f644ccbadcc68da0d5af459
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26581 (2011)
Sustained β-adrenergic receptors (βAR) activation leads to cardiac hypertrophy and prevents left ventricular (LV) atrophy during LV unloading. The immediate signaling pathways downstream from βAR stimulation, however, have not been well investigat
Externí odkaz:
https://doaj.org/article/baf59d98df444db68c04b49379b3c378