Výsledky vyhledávání - "Naohiro Yabuta"

A novel therapeutic approach for thrombocytopenia by minibody agonist of the thrombopoietin receptor

Autor: Yuichi Hirata, Akihisa Kaneko, Kiyotaka Nakano, Takashi Yoshikubo, Hirofumi Sakumoto, Tetsuro Orita, Hiroyuki Tsunoda, Toshihiko Ohtomo, Masahiko Nanami, Naohiro Yabuta, Eiji Kumagai, Kouichiro Ono, Takeshi Yoshino, Masayuki Tsuchiya, Mikiyoshi Saito, Jun-ichi Nezu

Publikováno v: Blood. 105:562-566

Antibodies have brought valuable therapeutics in the clinical treatment of various diseases without serious adverse effects through their intrinsic features such as specific binding to the target antigen with high affinity, clinical safety as serum p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b359f478492a1e2f9c18f8109d96f63
https://doi.org/10.1182/blood-2004-04-1482

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Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor

Autor: Masateru Ohta, Yoshiaki Watanabe, Hirofumi Kodama, Toshiro Kozono, Takuya Shiraishi, Susumu Itoh, Haruhiko Sato, Takaki Koga, Masayuki Haramura, Yasufumi Kikuchi, Kunihiro Hattori, Akihisa Sakamoto, Naohiro Yabuta, Toru Esaki, Masayoshi Oh-eda, Shojiro Kadono

Publikováno v: Biochemical and Biophysical Research Communications. 324:1227-1233

The 3D structure of human factor VIIa/soluble tissue factor in complex with a peptide mimetic inhibitor, propylsulfonamide-D-Thr-Met-p-aminobenzamidine, is determined by X-ray crystallography. As compared with the interactions between thrombin and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e64d66cd4fa9c3521e5edf275db3e34
https://doi.org/10.1016/j.bbrc.2004.09.182

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Phosphoenolpyruvate Carboxylase of Maize Leaves: an Improved Method for Purification and Reduction of the Inhibitory Effect of Malate by Ethylene Glycol and Bicarbonate

Autor: Naohiro Yabuta, Noriyuki Ogawa, Takako Kai, Katsura Izui

Publikováno v: Plant and Cell Physiology. 38:76-80

Light-adapted and dark-adapted forms of phosphoenolpyruvate carboxylase were purified from maize leaves by an improved method that included chromatography on Butyl-Toyopearl in the presence of ethylene glycol. The inhibition by malate was relieved no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::171517960673edc1725a3b4355e52900
https://doi.org/10.1093/oxfordjournals.pcp.a029088

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Organizational Applications of Failure Knowledge Management

Autor: Takeo Ohashi, Masayuki Nakao, Masahiro Terabe, Jun Kawai, Naohiro Yabuta

Publikováno v: Volume 2: 31st Design Automation Conference, Parts A and B.

In and after about the year 2000, organizations have started to build databases of workers’ accidents, troubles in the production processes, and customer complaints to make positive use of such failure information. For quantifying such organization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6572c1625a9079c92c389a185206e7e
https://doi.org/10.1115/detc2005-84543

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Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor

Publikováno v: Biochemical and biophysical research communications. 327(2)

Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs of the P3 moiety in the peptide mimetic factor VIIa inhibitor successfully lead to novel i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde48dd3dc15c06d9b65d1431bbfc3d3
https://pubmed.ncbi.nlm.nih.gov/15629154

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Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4

Autor: Yoshiyuki Ono, Toshiro Kozono, Hirofumi Kodama, Masayuki Haramura, Shojiro Kadono, Toru Esaki, Masayoshi Oh-eda, Yoshiaki Watanabe, Naohiro Yabuta, Yasufumi Kikuchi, Takaki Koga, Masateru Ohta, Akihisa Sakamoto, Susumu Itoh, Kunihiro Hattori, Takuya Shiraishi, Haruhiko Sato

Publikováno v: Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 2)

The crystal structure of human factor VIIa/soluble tissue factor (FVIIa/sTF) in complex with a highly selective peptide-mimetic FVIIa inhibitor which shows 1670-fold selectivity against thrombin inhibition has been solved at 2.6 A resolution. The inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890abd4aaf01da623042af495830e3a7
https://pubmed.ncbi.nlm.nih.gov/16510984

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Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor

Publikováno v: Biochemical and biophysical research communications. 326(4)

Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. A novel peptide mimetic factor VIIa inhibitor, ethylsulfonamide-d-biphenylalanine-Gln-p-aminobenzamidine, shows 10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57eed0b5a7083f02f7cf51f8a133a5df
https://pubmed.ncbi.nlm.nih.gov/15607748

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