Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Autor: Jun-ichi Satoh, Yoji Yamamoto, Shouta Kitano, Mika Takitani, Naohiro Asahina, Yoshihiro Kino

Publikováno v: Journal of Central Nervous System Disease, Vol 2014, Iss 6, Pp 69-78 (2014)

Externí odkaz: https://doaj.org/article/3c9589b5c8c6430bb886f33feeaf74c8

Bioinformatics data mining approach indicates the expression of chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq)-based hypoxia-inducible factor-1α target genes in periplaque lesions of multiple sclerosis

Autor: Jun-ichi Satoh, Naohiro Asahina, Shouta Kitano, Yoshihiro Kino

Publikováno v: Clinical and Experimental Neuroimmunology. 6:159-169

Objectives Hypoxia, a hallmark feature of chronic inflammation, plays a key role in the development of inflammatory demyelinating lesions of multiple sclerosis (MS). Periplaque demyelinated lesions (PDL) of MS represent incompletely demyelinated lesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::151bcd162076e6b3d97390f06d617cbc
https://doi.org/10.1111/cen3.12195

Molecular Network Analysis Suggests a Logical Hypothesis for the Pathological Role of C9orf72 in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia

Autor: Yoji Yamamoto, Jun-ichi Satoh, Shouta Kitano, Yoshihiro Kino, Mika Takitani, Naohiro Asahina

Publikováno v: Journal of Central Nervous System Disease
Journal of Central Nervous System Disease, Vol 2014, Iss 6, Pp 69-78 (2014)
Journal of Central Nervous System Disease, Vol 6 (2014)

Background Expanded GGGGCC hexanucleotide repeats, ranging from hundreds to thousands in number, located in the noncoding region of the chromosome 9 open reading frame 72 ( C9orf72) gene represent the most common genetic abnormality for familial and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04050223e56c29d2be91e3360f465114
http://europepmc.org/articles/PMC4149381

TMEM119 marks a subset of microglia in the human brain

Autor: Jun-ichi, Satoh, Yoshihiro, Kino, Naohiro, Asahina, Mika, Takitani, Junko, Miyoshi, Tsuyoshi, Ishida, Yuko, Saito

Publikováno v: Neuropathology : official journal of the Japanese Society of Neuropathology. 36(1)

Microglia are resident myeloid cells of the central nervous system (CNS), activated in the brains of various neurological diseases. Microglia are ontogenetically and functionally distinct from monocyte-derived macrophages that infiltrate the CNS unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddffb54442ee5a121aed6e868ea72644
https://pubmed.ncbi.nlm.nih.gov/26250788