Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Naohiko, Hayakawa"'
Publikováno v:
Biomedical Research. 36:71-80
Clinical trials involving in patients with osteoporosis have reported that activated vitamin D3 (1α,25(OH)2D3, calcitriol) can prevent falling by acting on the skeletal muscles. However, pharmacological mechanisms of 1α,25(OH)2D3 with respect to sk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1ca3781abc494243a7e1f4f8f404ad
https://doi.org/10.2220/biomedres.36.71
https://doi.org/10.2220/biomedres.36.71
Publikováno v:
Inflammation and Regeneration. 33:156-163
IL-6 is known as a multifunctional cytokine regulating immune response and inflammation. Many studies have shown that IL-6 affects the nervous system. However, the involvement of IL-6 in the nervous system, particularly in the peripheral nervous syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2553600f570a3322b2bd19adeaa32172
https://doi.org/10.2492/inflammregen.33.156
https://doi.org/10.2492/inflammregen.33.156
Autor:
Naohiko Hayakawa, Hiroto Yoshida, Masahiko Mihara, Atsuko Sugita, Takashi Nishimura, Yasushi Uchiyama, Nobuo Koike
Publikováno v:
International Immunopharmacology. 8:1595-1601
We explored the mechanism for the increase of blood IL-6 level after anti-IL-6 receptor (IL-6R) antibody injection. First, we examined whether anti-IL-6R antibody stimulates IL-6 production. Single injection of tocilizumab (anti-IL-6R antibody) in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f9b1d6c9fdd2e22c1893a92500c905
https://doi.org/10.1016/j.intimp.2008.07.002
https://doi.org/10.1016/j.intimp.2008.07.002
Publikováno v:
Rheumatology. 47:1635-1640
Objectives. We investigated the influence of cytokines on the expression of RANK ligand (RANKL) in fibroblast-like synoviocytes from RA patients (RA-FLS). Methods. RA-FLS were stimulated by IL-6, TNF-� , IL-17 and IL-1� with or without soluble IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d222a76890dc8ee21b3c7521e9edc8
https://doi.org/10.1093/rheumatology/ken363
https://doi.org/10.1093/rheumatology/ken363
Publikováno v:
Experimental Dermatology. 17:133-138
For the localization of drugs and related functional characterization, cellular-subcellular resolution can be achieved with radiolabelled compounds of high specific activity and receptor microscopic autoradiography, which is the method of choice for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0316110850584f81bd0b7292fb8efcb
https://doi.org/10.1111/j.1600-0625.2007.00636.x
https://doi.org/10.1111/j.1600-0625.2007.00636.x
Autor:
Naohiko Hayakawa, Walter E. Stumpf
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 32:123-129
Receptor binding with 3H-1,25(OH)2 vitamin D3 (vitamin D) and its oxygen analog 3H-OCT is demonstrated in rat, hamster, and mice submandibular, sublingual and parotid glands, using receptor microautoradiography high-resolution imaging. Nuclear uptake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b60b5b0ae0f61bdc9d2273a50bf1d6
https://doi.org/10.1007/bf03190474
https://doi.org/10.1007/bf03190474
Autor:
Toshifumi Sakaguchi, Tadashi Okada, Shigeo Negi, Ikuo Imazeki, Naohiko Hayakawa, Tadao Akizawa, Ikuji Hatamura, Kazuhiro Shiizaki, Takashi Shigematsu
Publikováno v:
Nephrology Dialysis Transplantation. 22:1078-1086
Background. Injection of maxacalcitol (OCT) directly into the parathyroid gland (PTG) is a clinically safe and effective treatment for advanced secondary hyperparathyroidism (A-SHPT) resistant to conventional medical treatment. In the present study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740e7d2c6b283bec82a5c5c5ff052c57
https://doi.org/10.1093/ndt/gfl713
https://doi.org/10.1093/ndt/gfl713
Publikováno v:
Calcified Tissue International. 78:152-161
The purpose of this study was to assess whether a nutritional supply of calcium (Ca) could be substituted for alfacalcidol (ALF) administration in preventing bone loss due to estrogen deficiency. Female Wistar-Imamichi rats (8 months old) were ovarie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a073800521dfa61d0559f632a4ebd5a
https://doi.org/10.1007/s00223-005-0014-y
https://doi.org/10.1007/s00223-005-0014-y
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 50:131-137
Introduction: Microscopic autoradiography with cellular resolution and preservation of in vivo conditions is potentially the method of choice to gain detailed information about sites of deposition and retention in the epidermis and of penetration to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf0ba084d527338527244e13683bb95
https://doi.org/10.1016/j.vascn.2004.03.012
https://doi.org/10.1016/j.vascn.2004.03.012
Autor:
Kazuhiro Nishimiya, Kazuo Tokuda, Walter E. Stumpf, Nobuo Koike, Naohiko Hayakawa, Kimitoshi Saito
Publikováno v:
Nephrology Dialysis Transplantation. 17:53-57
1,25-Dihydroxy-22-oxavitamin D(3) (22-oxacalcitriol, OCT), is a new synthetic analogue of 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3), calcitriol), to be used in the treatment of secondary hyperparathyroidism. This study used receptor micro-autoradio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9adfd5357dcd1feb6f4ec1b3b4c3979a
https://doi.org/10.1093/ndt/17.suppl_10.53
https://doi.org/10.1093/ndt/17.suppl_10.53