Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Naohide Kanemoto"'
Autor:
Yuki Inoue, Junichi Kino, Nobuya Ishiharada, Makoto Sato, Suguru Hatanaka, Hiroyuki Yokoi, Takahiro Shimada, Seiji Sato, Takashi Okamoto, Naohide Kanemoto
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 21, Pp 213-235 (2022)
Mitochondrial uncouplers (mUncouplers) are known to exhibit a variety of toxic effects in animals. Here we report a safety profile of an mUncoupler, OPC-163493, recently synthesized at Otsuka Pharmaceutical Co, Ltd, and its development as a therapeut
Externí odkaz:
https://doaj.org/article/2d5cb15c9a754b4994b438043fd9f323
Autor:
Takashi Okamoto, Takahiro Shimada, Chiharu Matsumura, Hitomi Minoshima, Takashi Ban, Motohiro Itotani, Toshio Shinohara, Shigekazu Fujita, Satoshi Matsuda, Seiji Sato, Naohide Kanemoto
Publikováno v:
ACS Omega, Vol 6, Iss 26, Pp 16980-16988 (2021)
Externí odkaz:
https://doaj.org/article/eb415dadc2c94e299aed0c67c5cdc4e6
Autor:
Naohide Kanemoto, Takashi Okamoto, Koji Tanabe, Takahiro Shimada, Hitomi Minoshima, Yuya Hidoh, Masashi Aoyama, Takashi Ban, Yusuke Kobayashi, Hikaru Ando, Yuki Inoue, Motohiro Itotani, Seiji Sato
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Mitochondrial uncoupling is a treatment strategy for metabolic diseases that reduces the efficiency of mitochondrial oxidative phosphorylation and ATP generation. Here the authors characterize the pharmacokinetic and therapeutic properties of the liv
Externí odkaz:
https://doaj.org/article/4cf4897abcfc4f0d9a71c0c81db9eeb9
Publikováno v:
Toxicological Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9477060810da66a347983eb02649f00
https://doi.org/10.1007/s43188-023-00189-x
https://doi.org/10.1007/s43188-023-00189-x
Autor:
Motohiro Itotani, Hitomi Minoshima, Naohide Kanemoto, Shigekazu Fujita, Satoshi Matsuda, Takashi Ban, Seiji Sato, Takashi Okamoto, Takahiro Shimada, Toshio Shinohara, Chiharu Matsumura
Publikováno v:
ACS Omega, Vol 6, Iss 26, Pp 16980-16988 (2021)
ACS Omega
ACS Omega
We serendipitously found a mitochondrial uncoupler (mUncoupler), compound 1, in the process of screening for inhibitors of a gene product related to calorie restriction (CR) and longevity. Compound 1 has a unique 4-cyano-1,2,3-triazole structure whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabc329cc8c21b81215b4e8f492367fa
https://doaj.org/article/eb415dadc2c94e299aed0c67c5cdc4e6
https://doaj.org/article/eb415dadc2c94e299aed0c67c5cdc4e6
Autor:
Yusuke Kobayashi, Yuya Hidoh, Koji Tanabe, Hikaru Ando, Yuki Inoue, Masashi Aoyama, Takashi Ban, Takahiro Shimada, Seiji Sato, Takashi Okamoto, Motohiro Itotani, Naohide Kanemoto, Hitomi Minoshima
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications
Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048ce2ad8f5525d2de7a7dcb26b593bc
http://link.springer.com/article/10.1038/s41467-019-09911-6
http://link.springer.com/article/10.1038/s41467-019-09911-6
Autor:
Toshihisa Takagi, Takeshi K. Watanabe, Akira Tanigami, Naohide Kanemoto, Atsushi B. Tsuji, Toshihide Ono, Keiko Oga, Yusuke Nakamura, Ayako Mizoguchi-Miyakita, Haretsugu Hishigaki, Yuki Yamasaki, Mikio Suzuki, Shiro Okuno, Shigeyuki Wakitani
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 32(5-6):355-366
SUMMARY 1. We have confirmed the Diabetes Mellitus OLETF type I (Dmo1) effect on hyperphagia, dyslipidaemia and obesity in the Otsuka Long-Evans Tokushima Fatty (OLETF) strain. The critical interval was narrowed down to 570 kb between D1Got258 to p16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8459f48e3b5ce7dd602ef035c70531e
https://repo.qst.go.jp/records/43711
https://repo.qst.go.jp/records/43711
Autor:
Ayako Mizoguchi-Miyakita, Keiko Oga, Masato Nose, Naohide Kanemoto, Takeshi K. Watanabe, Akira Tanigami, Haretsugu Hishigaki, Atsushi B. Tsuji, Mari Kondo, Shiro Okuno, Tomoyuki Iwanaga, Toshihide Ono
Publikováno v:
Pathology International. 51:133-139
An Otsuka Long-Evans Tokushima Fatty (OLETF) strain of rat spontaneously developed hyperglycemia, hyperinsulinemia, insulin resistance and mild obesity, which had been studied as animal model for type II diabetes mellitus (T2DM). Recently, we observe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99a40a7819855617fca21d329073251
https://doi.org/10.1046/j.1440-1827.2001.01176.x
https://doi.org/10.1046/j.1440-1827.2001.01176.x
Autor:
Yusuke Nakamura, Toyoki Mori, Yoshihiro Taniguchi, Akira Tanigami, Masato Horie, Naohide Kanemoto, Akihito Watanabe, Naoki Nishino, Mari Kondo, Takashi Okamoto, Ei-ichi Takahashi, Hiroyuki Kyushiki, Yasuhide Mitsumoto, Koichi Noguchi
Publikováno v:
Genomics. 67:146-152
We have identified a novel mammalian gene, TMEFF2, that encodes a putative transmembrane protein containing two follistatin-like domains and one epidermal growth factor (EGF)-like domain. The TMEFF2 gene is predominantly expressed in the brain. In si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b176d52d559e2bff04df48564ad70e39
https://doi.org/10.1006/geno.2000.6228
https://doi.org/10.1006/geno.2000.6228
Autor:
Keiko Oga, Ayako Mizoguchi-Miyakita, Michael R. James, G. M. Lathrop, Toshihisa Takagi, Yusuke Nakamura, Ei Ichi Takahashi, Yasuo Irie, Naohide Kanemoto, Yuki Yamasaki, Takeshi K. Watanabe, M. T. Bihoreau, Haretsugu Hishigaki, Akira Tanigami, Shiro Okuno, Toshihide Ono
Publikováno v:
Mammalian Genome. 11:300-305
We have isolated more than 12,000 clones containing microsatellite sequences, mainly consisting of (CA)n dinucleotide repeats, using genomic DNA from the BN strain of laboratory rat. Data trimming yielded 9636 non-redundant microsatellite sequences,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240ecbc118eb2c72f7af3a5cbbe3fdbe
https://doi.org/10.1007/s003350010056
https://doi.org/10.1007/s003350010056