Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Naoharu, Takano"'
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0307662 (2024)
Promising outcomes have been reported in elder patients with acute myeloid leukemia (AML) using combined therapy of venetoclax (VEN) and azacytidine (AZA) in recent years. However, approximately one-third of patients appear to be refractory to this t
Externí odkaz:
https://doaj.org/article/41c15908f9024d1583b15934784765e2
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Lysosomes are single-membraned organelles that mediate the intracellular degradation of macromolecules. Various stress can induce lysosomal membrane permeabilization (LMP), translocating intralysosomal components, such as cathepsins, to the
Externí odkaz:
https://doaj.org/article/9e6edb9a15e24e839ad03cd07c6712da
Autor:
Shota Moriya, Hiromi Kazama, Hirotsugu Hino, Naoharu Takano, Masaki Hiramoto, Shin Aizawa, Keisuke Miyazawa
Publikováno v:
PLoS ONE, Vol 18, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/00b3bbb8cd044e8baf6fb9baafd862b3
Autor:
Kana Miyahara, Naoharu Takano, Yumiko Yamada, Hiromi Kazama, Mayumi Tokuhisa, Hirotsugu Hino, Koji Fujita, Edward Barroga, Masaki Hiramoto, Hiroshi Handa, Masahiko Kuroda, Takashi Ishikawa, Keisuke Miyazawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract BRCA1 is a well-studied tumor suppressor involved in the homologous repair of DNA damage, whereas PINK1, a mitochondrial serine/threonine kinase, is known to be involved in mitochondrial quality control. Genetic mutations of PINK1 and Parkin
Externí odkaz:
https://doaj.org/article/2b53b82c6ae5403ab382220048b0b353
Autor:
Naoharu Takano, Masaki Hiramoto, Yumiko Yamada, Hiroko Kokuba, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa
Publikováno v:
British Journal of Cancer. 128:1838-1849
Background Autophagy plays an important role in tumour cell growth and survival and also promotes resistance to chemotherapy. Hence, autophagy has been targeted for cancer therapy. We previously reported that macrolide antibiotics including azithromy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b0504bf8c1dce1a1821fa8c6646c1d
https://doi.org/10.1038/s41416-023-02210-4
https://doi.org/10.1038/s41416-023-02210-4
Autor:
Hideki Tanaka, Hirotsugu Hino, Shota Moriya, Hiromi Kazama, Masaya Miyazaki, Naoharu Takano, Masaki Hiramoto, Kiyoaki Tsukahara, Keisuke Miyazawa
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Tyrosine kinase inhibitors (TKIs) induce autophagy in many types of cancer cells. We previously reported that gefitinib (GEF) and imatinib (IMA) induce autophagy in epidermal growth factor receptor (EGFR) knock-out A549 and non-BCR-ABL-expressing leu
Externí odkaz:
https://doaj.org/article/c639655190624e29aa720337aaa658e3
Autor:
Gregg L. Semenza, David Zagzag, Makoto Suematsu, Lisha Xiang, Pallavi Chaturvedi, Daniele M. Gilkes, Yasmeen Sarfraz, Naoharu Takano
Supplementary Figure S1. Cell proliferation of U87-MG subclones in vitro. 5,000 cells were seeded and cultured under 20% or 1% O2. Viable cell number was counted by trypan blue staining on days 2, 3, and 4, and normalized to the starting cell number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4ac815d72fef7415ab317e32b2239d
https://doi.org/10.1158/1541-7786.22514200.v1
https://doi.org/10.1158/1541-7786.22514200.v1
Autor:
Masaki Hiramoto, Keisuke Miyazawa, Akihisa Abe, Hiroko Kokuba, Shota Moriya, Atsuo Takeda, Kiyoaki Tsukahara, Hirotsugu Hino, Naoharu Takano
Publikováno v:
International Journal of Oncology
The proton pump inhibitor lansoprazole (LPZ) inhibits the growth of several cancer cell lines, including A549 and CAL 27. We previously reported that macrolide antibiotics such as azithromycin (AZM) and clarithromycin (CAM) potently inhibit autophagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8d6f2ada77ba30f64072600dbdd261
http://europepmc.org/articles/PMC7646592
http://europepmc.org/articles/PMC7646592
Autor:
Naoharu Takano, Masaya Miyazaki, Ayuka Yokota, Mayumi Tokuhisa, Hirotsugu Hino, Keisuke Miyazawa, Masaki Hiramoto, Hiromi Kazama
Publikováno v:
Biochemical and Biophysical Research Communications. 531:256-263
Sequestosome 1 (p62) is a multifunctional adapter protein involved in various physiological functions, such as selective autophagy and oxidative stress response. Hence, aberrant expression and defective regulation of p62 are thought to lead to the on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160821ae947b34edd4b45448a107e921
https://doi.org/10.1016/j.bbrc.2020.07.058
https://doi.org/10.1016/j.bbrc.2020.07.058
Autor:
Hirotsugu Hino, Mayumi Tokuhisa, Keisuke Miyazawa, Masaki Hiramoto, Naoharu Takano, Jun Takemura, Hiroko Kokuba, Masaya Miyazaki, Hiromi Kazama
Publikováno v:
International Journal of Molecular Medicine
The autophagy‑lysosome system allows cells to adapt to environmental changes by regulating the degradation and recycling of cellular components, and to maintain homeostasis by removing aggregated proteins and defective organelles. Cyclin G‑associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f69d2441574965dc8b7821c0aae365
https://doi.org/10.3892/ijmm.2021.5028
https://doi.org/10.3892/ijmm.2021.5028