Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Naofumi Hikita"'
Autor:
Kunihiro Fukushi, Hiroshi Takase, Chikako Taguchi, Sunao Sugita, Jun Sueda, Kyogo Itoh, Kimitaka Sagawa, Naofumi Hikita, Toshiki Watanabe, Manabu Mochizuki
Publikováno v:
British Journal of Ophthalmology. 84:1130-1134
AIMS—To investigate the presence of soluble Fas ligand (sFasL) and soluble Fas (sFas) in ocular fluid of patients with uveitis. METHODS—Samples of aqueous humour (AH, n=17), vitreous fluid (n=9), and serum (n=60) were collected from patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71fadcd1ce078eb7187644b6a58f1c66
https://doi.org/10.1136/bjo.84.10.1130
https://doi.org/10.1136/bjo.84.10.1130
Publikováno v:
Experimental Eye Research. 70:7-15
The immunosuppressive properties of FTY720, a novel immunosuppressant obtained by structural modification of ISP-I isolated from the fermentation broth of Isaria sinclairii, were studied in experimental autoimmune uveoretinitis (EAU) in rats. Lewis r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d4a19560bc3f4baae640b8e739b62e
https://doi.org/10.1006/exer.1999.0777
https://doi.org/10.1006/exer.1999.0777
Autor:
Ayako Ono, Naofumi Hikita, Kimitaka Sagawa, Manabu Mochizuki, Toshiki Watanabe, Kyogo Ito, Kazunari Yamaguchi, Eiko Ikeda
Publikováno v:
Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 13:S50-S56
Human T-cell lymphotropic virus type I (HTLV-I) is known to cause adult T-cell leukemia/T-cell lymphoma and tropical spastic paraparesis/HTLV-I-associated myelopathy. Recent seroepidemiologic, clinical, and virologic studies indicate that the virus i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7b7da1b961c8c1693be493a2b14876
https://doi.org/10.1097/00042560-199600001-00010
https://doi.org/10.1097/00042560-199600001-00010
Autor:
Robert B. Nussenblatt, Scott M. Whitcup, Naofumi Hikita, Manabu Mochizuki, Masayuki Miyasaka, Takuya Tamatani, M Shirao, Chi-Chao Chan
Publikováno v:
Experimental Eye Research. 60:597-601
We studied the effect of monoclonal antibodies (mAbs) against CD54 (intercellular adhesion molecule-1; ICAM-1) and CD11a (lymphocyte function-associated antigen-1; LFA-1) on the prevention and treatment of endotoxin-induced uveitis (EIU). When treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f441453d53a5c915313ee70bd1471a
https://doi.org/10.1016/s0014-4835(05)80001-6
https://doi.org/10.1016/s0014-4835(05)80001-6
Autor:
Kourosh Dastgheib, Robert B. Nussenblatt, Chi-Chao Chan, Naofumi Hikita, Scott M. Whitcup, Igal Gery
Publikováno v:
Ophthalmology. 101:1275-1280
Purpose: To study the immunopathology of experimental melanin-protein-induced uveitis in the Lewis rat. Methods: Rats were immunized with bovine ocular melanin protein. The kinetics of experimental melanin-protein-induced uveitis was studied by clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::867e9821eebdc1849471ae6841322279
https://doi.org/10.1016/s0161-6420(94)31199-7
https://doi.org/10.1016/s0161-6420(94)31199-7
Autor:
Naofumi Hikita, Kourosh Dastgheib, Devora Sredni, Benjamin Sredni, Robert B. Nussenblatt, Chi-Chao Chan, Michael Albeck
Publikováno v:
Current Eye Research. 13:603-610
The purpose of this study was to investigate the effect of a novel immunomodulator, AS101 [ammonium trichloro(dioxyethelene-O-O') tellurate], in the eye. Lewis rats were injected intravitreally with AS101 at a concentration of 13 micrograms/ml in one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de54a3bc96f0c51263ca2462ad6b1a6e
https://doi.org/10.3109/02713689408999894
https://doi.org/10.3109/02713689408999894
Autor:
Qian Li, Robert B. Nussenblatt, Yujiro Fujino, Naofumi Hikita, Chi-Chao Chan, Hum Chung, Igal Gery
Publikováno v:
Autoimmunity. 13:303-309
The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Hist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6531859c34d269632ee51b2aa4fc0d4
https://doi.org/10.3109/08916939209112339
https://doi.org/10.3109/08916939209112339
Publikováno v:
Japanese journal of ophthalmology. 41(6)
Tacrolimus and rapamycin both belong to a new family of immunosuppressants, immunophilin ligands, but the mechanisms by which they inhibit T cell activation are different. Therefore, we tested the immunosuppressive effects of combination therapy with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054985c91ded8bf4cc4455a7b5670289
https://pubmed.ncbi.nlm.nih.gov/9509307
https://pubmed.ncbi.nlm.nih.gov/9509307
Publikováno v:
International archives of allergy and immunology. 109(3)
A mouse model of conjunctivitis has been developed by topical application of compound 48/80 (C48/80), an agent that triggers mast cell degranulation. We examined the responsiveness of C57BL/6, C3H/HeN, and ASW/J mouse strains to C48/80 stimulation, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12af976744978255214160026cbb5634
https://pubmed.ncbi.nlm.nih.gov/8620098
https://pubmed.ncbi.nlm.nih.gov/8620098
Publikováno v:
Current eye research. 14(3)
FK506 is a macrolide antibiotic and a potent immunosuppressant. To investigate the effect of topical FK506 on acute ocular inflammation, we evaluated its action on the development of endotoxin-induced uveitis (EIU). At two different concentrations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93fee5a2851af4504570cbfa562120f3
https://pubmed.ncbi.nlm.nih.gov/7540967
https://pubmed.ncbi.nlm.nih.gov/7540967