Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Naoe Taira Nihira"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/302aa84327884208854f98eea2606646
Autor:
Naoe Taira Nihira, Yoshio Miki
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Tumor cells are eliminated by the immune system, including T lymphocytes and natural killer cells; however, many types of tumor cells acquire the immune tolerance by inhibiting T-cell activation and functions via immune checkpoint molecules. Immunoth
Externí odkaz:
https://doaj.org/article/c71e9d011ef9452ca1316a6badde847f
Autor:
Jing Zhu, Wenwen Wu, Yukiko Togashi, Naoe Taira Nihira, Yoshikazu Johmura, Dajiang Zhu, Makoto Nakanishi, Yasuo Miyoshi, Tomohiko Ohta
Publikováno v:
Breast cancer (Tokyo, Japan). 29(6)
Background Sacituzumab govitecan is an antibody–drug conjugate that delivers SN-38, an active metabolite of irinotecan, to the target molecule, trophoblast cell-surface antigen 2 (Trop-2). It is a promising drug for triple-negative breast cancer an
Autor:
Aleksandra Kolodziejczyk, Yang Gao, Yan Geng, Yizeng Fan, Ngai Ting Chan, Naoe Taira Nihira, Akira Nakanishi, Samanta Sharma, Jinfang Zhang, X. Shirley Liu, Xiaoming Dai, Yu Han Huang, Brian J. North, Xia Bu, Jing Liu, Huadong Liu, Wenyi Wei, Gordon J. Freeman, Dong Wang, Chen Chu, Masaya Ono, Leina Ma, Yoshio Miki, Hiroyuki Inuzuka, Piotr Sicinski, Wei Xu, Lei Li
Publikováno v:
Nature cell biology
Immunotherapies that target programmed cell death protein 1 (PD-1) and its ligand PD-L1 as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) have shown impressive clinical outcomes for multiple tumours. However, only a subset of patients ac
Autor:
Juehong Wang, Jeremy W. Prokop, Le Su, Tadashi Kondo, Kumiko Shiozawa, Makoto Endo, Nikita Patel, Richard M. Myers, Laurel A. Brandsmeier, Kelly M. McNagny, Sarah Meadows, Naoe Taira Nihira, T. Michael Underhill, Arthur V. Sampaio, George G. Davenport, Yanfeng Zhang, Derek Wong, Zhenyue Hao, Kevin B. Jones, Tak W. Mak, Torsten O. Nielsen, Ryan Vander Werff, Mario R. Capecchi
Publikováno v:
iScience
iScience, Vol 13, Iss, Pp 43-54 (2019)
iScience, Vol 13, Iss, Pp 43-54 (2019)
Summary Histone deacetylases (HDACs) are promising targets for cancer therapy, although their individual actions remain incompletely understood. Here, we identify a role for HDAC2 in the regulation of MDM2 acetylation at previously uncharacterized ly
Autor:
Katsuhiko Aoki, Hiroyuki Takeda, Takenori Yamamoto, Tatsuya Sawasaki, Naoe Taira Nihira, Kiyotsugu Yoshida, Satomi Yogosawa
Publikováno v:
FEBS Letters. 591:842-853
The genome of eukaryotic cells is frequently exposed to damage by various genotoxins. Phosphorylation of histone H2AX at Serine 139 (γ-H2AX) is a hallmark of DNA damage. RNF8 monoubiquitinates γ-H2AX with the Lys63-linked ubiquitin chain to tether
Autor:
Hiroyuki Inuzuka, Wojciech Michowski, Li Na, J. Wade Harper, Joel M. Chick, Kornelia Polyak, Kouhei Shimizu, Roderick T. Bronson, Wenyi Wei, Aleksandra Kolodziejczyk, Lijun Liu, Keith L. Ligon, Piotr Sicinski, Naoe Taira Nihira, Alice Y. Meng, Yan Geng, Steven P. Gygi, Alban Ordureau
Publikováno v:
Nature Cell Biology. 19:177-188
Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by the D-type and E-type cyclins. According to the current models, at least one of these cyclin families must be present to allow cell proliferation. Here, we show
Publikováno v:
Science Signaling. 11
The PI3K-AKT kinase signaling pathway is frequently deregulated in human cancers, particularly breast cancer, where amplification and somatic mutations of PIK3CA occur with high frequency in patients. Numerous small-molecule inhibitors targeting both
Publikováno v:
Cellular signalling. 46
FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCF(FBW7) plays key roles in regulating cell cycle progression, differentiatio
Autor:
Kiyotsugu Yoshida, Naoe Taira Nihira
Publikováno v:
Cell Cycle. 14:802-807
Dysregulation of cell cycle machinery causes abnormal cell division, leading to cancer development. To drive cell cycle properly, expression levels of cell cycle regulators are tightly regulated through the cell cycle. Dual specificity tyrosine phosp