Výsledky vyhledávání

In vivo Effect of Monoclonal Antibodies Against the Platelet GPIIb/IIIa

Autor: Kojiro Yasunaga, Hirokazu Nagata, Kazuyuki Yamaguti, Masahiko Suzuki, T. Kokawa, Tetuji Soga, Shosaku Nomura, M. Yanabu, Naoaki Sone

Publikováno v: Japanese Journal of Thrombosis and Hemostasis. 2:136-142

Anti-human GPIIb/IIIa mouse monoclonal antibodies, NNKY2-11 and NNKY2-18, reacted with platelets of dogs, cats and monkeys as well as humans. These antibodies inhibited the platelet aggregations of humans and animals in vitro. In this report, we inje

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6df6bd43a84ccca7a0d1e9ce20b8dc7d
https://doi.org/10.2491/jjsth.2.136

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Monkey Platelet Membrane Glycoproteins and Aggregation

Autor: Kojiro Yasunaga, Toshihiro Kawakatsu, Hirokazu Nagata, Masahiko Suzuki, Koji Iwata, Terutoshi Kokawa, Mutsumasa Yanabu, Shosaku Nomura, Naoaki Sone, Tetsuji Soga

Publikováno v: Japanese Journal of Thrombosis and Hemostasis. 2:128-135

The monkey is classified as close to the human and is important as an experimental animal. The present study, a comparison of human and monkey platelet membrane glycopreteins and aggregation, was undertaken.The major platelet membrane glycoprotein wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dd0f03e0fb8fcdf27064468ad4f0623
https://doi.org/10.2491/jjsth.2.128

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Some Monoclonal Anti-human-platelet Antibodies Recognize Dog Platelets as Antigens

Autor: Hirokazu Nagata, Kazuyuki Yamaguchi, Masahiko Suzuki, Terutoshi Kokawa, Naoaki Sone, Kojiro Yasunaga, Tetsuji Soga, M. Yanabu, Shosaku Nomura

Publikováno v: Japanese Journal of Thrombosis and Hemostasis. 1:482-488

Among monoclonal antibodies reacting to platelets, some GPIIb/IIIa antibodies have been reported to react to the platelets of different animals.In this study, we searched for common antigens for platelets of dogs and humans, using 11 monoclonal anti-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc2e46658b290318c578793fcc6fa135
https://doi.org/10.2491/jjsth.1.482

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A Family of Hereditary Thrombocytopenic Purpura

Autor: Mutsumasa Yanabu, Kojiro Yasunaga, Masahiko Suzuki, Naoaki Sone, Hideo Kagawa, Tetsuji Soga, Koji Iwata, Shosaku Nomura, Terutoshi Kokawa, Hirokazu Nagata

Publikováno v: Japanese Journal of Thrombosis and Hemostasis. 1:255-261

Three cases in a family of hereditary thrombocytopenic purpura are reported. Each case presented as an idiopathic thrombocytopenic purpura (ITP)-like syndrome. Careful family history revealed that some other members had similar symptom, and the mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d135a697dac875114c2b26162459fb29
https://doi.org/10.2491/jjsth.1.255

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Kinetics of platelets in dogs with thrombocytopenia induced by antiglycoprotein IIb/IIIa receptor monoclonal antibody

Autor: Naoaki Sone, Kojiro Yasunaga, Masako N. Hosono, Makoto Hosono, Harumi Sakahara, Keigo Endo, Tsuneo Saga, Junji Konishi, Hisataka Kobayashi

Publikováno v: Nuclear medicine and biology. 22(1)

To experimentally assess the kinetics of platelets in thrombocytopenia, we constructed a canine model using 111In-oxine labeled autologous platelets and an intact antiplatelet monoclonal antibody (MAb) NNKY2-11 (IgG2a). With the infusion of radiolabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24f3ae213da7f0583d2752a19ffdfc9
https://pubmed.ncbi.nlm.nih.gov/7735173

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Change of platelets surface conformation in ADP- and collagen-induced aggregation

Autor: Hirokazu Nagata, Terutoshi Kokawa, Naoaki Sone, Kojiro Yasunaga, Kazuhiro Oda, Hiroyuki Kitajima, Chikaho Kitada, Shosaku Nomura

Publikováno v: Blood & Vessel. 19:260-263

We used four monoclonal antibodies against platelet membrane and flow cytometry to study the conformational change on the platelet surface in ADP or collagen stimulation. If ADP or collagen was added to normal PRP or to washed platelets that had been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6a9822e54fbb405e8e7afd0d48aecb
https://doi.org/10.2491/jjsth1970.19.260

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Binding Form of Platelet-Binding IgG Using Unfixed Platelets in Idiopathic Thrombocytopenic Purpura

Autor: Masahiko Suzuki, Kojiro Yasunaga, Naoaki Sone, Tsutomu Fukuroi, Hirokazu Nagata, Koji Iwata, Shosaku Nomura, Mutsumasa Yanabu, Hirofumi Kido, Tetsuji Saga, Kazuyuki Yamaguchi, Terutoshi Kokawa

Publikováno v: The Journal of Kansai Medical University. 41:S32-S39

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a071fdeaae042872b6aa5752f4ba2f09
https://doi.org/10.5361/jkmu1956.41.supplement_s32

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Role of cations on the platelet membrane GPIIb-IIIa complex

Autor: Tetsuji Soga, Shigetoshi Ohga, Hiroyuki Kitajima, Koji Kondo, Kojiro Yasunaga, Terutoshi Kokawa, Hirokazu Nagata, Naoaki Sone, Shosaku Nomura, Chikaho Kitada

Publikováno v: Blood & Vessel. 19:236-245

It has been reported that the GPIIb and GPIIIa exist predominantly as the Ca2+-dependent, heterodimer complex, and incubation of intact platelets with EDTA at 37°C causes progressive dissociation of GPIIb-IIIa complexes. We used two monoclonal antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6524add2928fbea848ecc4aa6645de3f
https://doi.org/10.2491/jjsth1970.19.236

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